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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | John D'Acquisto# | 280 | 1969 | |
| 2 | Dizzy Dean* | 264 | 1946 | |
| 3 | Noah Syndergaard# | 258 | 1968 | |
| 4 | Mat Latos# | 256 | 1968 | |
| 5 | Ed Correa# | 246 | 1969 | |
| 6 | Dizzy Dean* | 243 | 1955 | |
| 7 | Randy D Johnson | 236 | 1947 | |
| 8 | John D'Acquisto# | 235 | 1966 | |
| 9 | Jimmie Keenan# | 233 | 1964 | |
| 10 | Jimmie Keenan# | 231 | 1968 | |
| 11 | John D'Acquisto# | 228 | 1968 | |
| 11 | James Paxton# | 228 | 1968 | |
| 13 | Jimmie Keenan# | 226 | 1969 | |
| 14 | Jimmie Keenan# | 225 | 1965 | |
| 15 | Jimmie Keenan# | 223 | 1963 | |
| 16 | John D'Acquisto# | 222 | 1964 | |
| 17 | John Lackey# | 221 | 1967 | |
| 18 | Noah Syndergaard# | 218 | 1969 | |
| 18 | Kerry Wood# | 218 | 1969 | |
| 20 | Pat Malone | 217 | 1950 | |
| 20 | Mat Latos# | 217 | 1969 | |
| 20 | Pat Malone | 217 | 1952 | |
| 23 | Dizzy Dean* | 215 | 1954 | |
| 23 | John Lackey# | 215 | 1965 | |
| 25 | Dizzy Dean* | 214 | 1947 | |
| 25 | Jimmie Keenan# | 214 | 1966 | |
| 27 | Kerry Wood# | 210 | 1968 | |
| 27 | Jimmie Keenan# | 210 | 1967 | |
| 29 | John Lackey# | 209 | 1968 | |
| 29 | John D'Acquisto# | 209 | 1965 | |
| 31 | John Lackey# | 208 | 1966 | |
| 32 | Dizzy Dean* | 206 | 1949 | |
| 32 | Pat Malone | 206 | 1948 | |
| 34 | Pat Malone | 205 | 1956 | |
| 34 | Hal Brown# | 205 | 1968 | |
| 36 | Bill Monbouquette | 204 | 1953 | |
| 37 | Charlie Root | 203 | 1963 | |
| 37 | John Lackey# | 203 | 1964 | |
| 37 | Pat Malone | 203 | 1953 | |
| 40 | Dizzy Dean* | 202 | 1953 | |
| 41 | James Paxton# | 200 | 1969 | |
| 41 | Pat Malone | 200 | 1949 | |
| 43 | Matt Moore | 198 | 1953 | |
| 44 | Herb Score | 197 | 1950 | |
| 44 | Charlie Root | 197 | 1960 | |
| 46 | Hideo Nomo | 196 | 1958 | |
| 47 | Charlie Root | 195 | 1953 | |
| 47 | Chris R Young# | 195 | 1968 | |
| 49 | Kerry Wood# | 194 | 1967 | |
| 49 | Madison Bumgarner* | 194 | 1947 | |
| 49 | Schoolboy Rowe | 194 | 1946 | |
| 52 | Dizzy Dean* | 193 | 1952 | |
| 52 | Hideo Nomo | 193 | 1957 | |
| 52 | John D'Acquisto# | 193 | 1963 | |
| 52 | Charlie Root | 193 | 1958 | |
| 52 | Charlie Root | 193 | 1959 | |
| 52 | James Paxton# | 193 | 1963 | |
| 58 | Noah Syndergaard# | 192 | 1967 | |
| 59 | Brad Peacock | 191 | 1958 | |
| 59 | George Earnshaw | 191 | 1958 | |
| 61 | Diego Segui# | 190 | 1968 | |
| 61 | Charlie Root | 190 | 1957 | |
| 61 | Hideo Nomo | 190 | 1953 | |
| 61 | Hideo Nomo | 190 | 1955 | |
| 65 | Dizzy Dean* | 189 | 1948 | |
| 66 | Mike Boddicker# | 188 | 1968 | |
| 67 | Madison Bumgarner* | 187 | 1952 | |
| 68 | James Paxton# | 186 | 1962 | |
| 68 | Juan Marichal | 186 | 1946 | |
| 68 | Pat Malone | 186 | 1955 | |
| 71 | Bob Sebra# | 185 | 1966 | |
| 71 | Yu Darvish | 185 | 1959 | |
| 71 | Jim Maloney | 185 | 1946 | |
| 74 | Yu Darvish | 184 | 1954 | |
| 75 | Rex Cecil | 183 | 1965 | |
| 75 | Yu Darvish | 183 | 1952 | |
| 77 | Doug Davis# | 182 | 1969 | |
| 77 | Bob Sebra# | 182 | 1962 | |
| 79 | Cloyd Boyer# | 181 | 1969 | |
| 79 | Madison Bumgarner* | 181 | 1953 | |
| 79 | Bob Sebra# | 181 | 1963 | |
| 82 | Charlie Root | 180 | 1961 | |
| 82 | Charlie Root | 180 | 1962 | |
| 84 | John D'Acquisto# | 178 | 1962 | |
| 85 | Wandy Rodriguez# | 177 | 1966 | |
| 86 | Diego Segui# | 176 | 1966 | |
| 87 | Steve D Barber | 175 | 1964 | |
| 87 | Mace Brown# | 175 | 1969 | |
| 87 | Vincent Velasquez | 175 | 1963 | |
| 87 | Bob Sebra# | 175 | 1965 | |
| 87 | Yu Darvish | 175 | 1950 | |
| 92 | Ben Sheets# | 174 | 1969 | |
| 93 | Osiris Matos | 173 | 1960 | |
| 93 | Madison Bumgarner* | 173 | 1950 | |
| 93 | Steve D Barber | 173 | 1963 | |
| 96 | Matt Moore | 172 | 1950 | |
| 96 | Al McBean# | 172 | 1966 | |
| 96 | Dizzy Dean* | 172 | 1950 | |
| 99 | Madison Bumgarner* | 171 | 1949 | |
| 99 | Yu Darvish | 171 | 1955 |
