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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Dizzy Dean* | 2663 | 1946-1961 | |
| 2 | Charlie Root | 2514 | 1951-1967 | |
| 3 | Madison Bumgarner* | 2500 | 1946-1962 | |
| 4 | Brett Cecil | 2174 | 1950-1969 | |
| 5 | Hideo Nomo | 2024 | 1948-1961 | |
| 6 | Pat Malone | 1957 | 1948-1960 | |
| 7 | James Paxton# | 1952 | 1957-1969 | |
| 8 | Jon Lester | 1898 | 1947-1966 | |
| 9 | John D'Acquisto# | 1836 | 1961-1969 | |
| 10 | Jimmie Keenan# | 1821 | 1960-1969 | |
| 11 | Yu Darvish | 1788 | 1950-1962 | |
| 12 | Lefty Williams | 1732 | 1946-1959 | |
| 13 | Steve D Barber | 1711 | 1953-1968 | |
| 14 | John Lackey# | 1662 | 1960-1969 | |
| 15 | Bob Sebra# | 1656 | 1959-1969 | |
| 16 | Danny Darwin | 1626 | 1947-1962 | |
| 17 | Bob Osborn | 1585 | 1947-1964 | |
| 18 | Chris Sale# | 1570 | 1955-1969 | |
| 19 | Jack Hallett | 1559 | 1955-1969 | |
| 20 | Frank Viola | 1549 | 1946-1961 | |
| 21 | Freddy Garcia# | 1542 | 1956-1969 | |
| 22 | Vincent Velasquez | 1519 | 1954-1969 | |
| 23 | Kenta Maeda# | 1518 | 1959-1969 | |
| 24 | Arthur Rhodes | 1513 | 1949-1963 | |
| 25 | Matt Clement | 1499 | 1946-1959 | |
| 26 | Corey Kluber | 1497 | 1948-1961 | |
| 27 | Tim Stauffer# | 1486 | 1956-1969 | |
| 28 | Kent Peterson# | 1479 | 1956-1969 | |
| 29 | Dillon Gee | 1458 | 1950-1966 | |
| 30 | Osiris Matos | 1437 | 1954-1967 | |
| 31 | Scott Bankhead | 1406 | 1953-1967 | |
| 32 | Francisco Cordova# | 1389 | 1955-1969 | |
| 33 | Matt Moore | 1383 | 1946-1958 | |
| 34 | Chan Ho Park | 1347 | 1949-1966 | |
| 35 | Darren Holmes# | 1346 | 1957-1969 | |
| 36 | Shawn Estes# | 1324 | 1959-1969 | |
| 37 | Mike Bruhert | 1319 | 1951-1968 | |
| 38 | Brad Peacock | 1311 | 1955-1967 | |
| 39 | Dennis Rasmussen | 1306 | 1950-1965 | |
| 40 | Mort Cooper | 1303 | 1946-1958 | |
| 41 | Phil Collins# | 1275 | 1956-1969 | |
| 42 | Bill Monbouquette | 1263 | 1946-1956 | |
| 43 | Ralph Birkofer# | 1232 | 1956-1969 | |
| 44 | Kirk McCaskill# | 1197 | 1961-1969 | |
| 45 | Scott T Baker | 1191 | 1946-1957 | |
| 46 | Shelby Miller | 1181 | 1953-1966 | |
| 47 | David Palmer# | 1173 | 1955-1969 | |
| 48 | Ownie Carroll | 1164 | 1948-1963 | |
| 49 | Clay Buchholz# | 1154 | 1959-1969 | |
| 50 | Juan Pizarro | 1148 | 1946-1963 | |
| 51 | Gio Gonzalez | 1145 | 1954-1967 | |
| 51 | Randy O'Neal | 1145 | 1952-1965 | |
| 53 | Larry Christenson | 1126 | 1946-1961 | |
| 54 | Aaron Harang# | 1123 | 1957-1969 | |
| 55 | Al McBean# | 1121 | 1962-1969 | |
| 56 | Milt Gaston# | 1098 | 1960-1968 | |
| 57 | Toby Borland | 1094 | 1955-1969 | |
| 58 | Sam Militello | 1092 | 1956-1967 | |
| 59 | Roger Craig | 1091 | 1950-1963 | |
| 60 | Tom Butters# | 1085 | 1958-1969 | |
| 61 | Alex Fernandez | 1083 | 1946-1956 | |
| 62 | Jeremy Bonderman | 1081 | 1958-1967 | |
| 63 | Glendon Rusch# | 1078 | 1961-1969 | |
| 64 | Stan Coveleski | 1076 | 1946-1959 | |
| 65 | Harry Kelley | 1047 | 1949-1965 | |
| 65 | Lary Sorensen# | 1047 | 1956-1969 | |
| 67 | A J Griffin | 1032 | 1949-1961 | |
| 68 | Schoolboy Rowe | 1030 | 1946-1958 | |
| 69 | Mike Smithson# | 1029 | 1961-1969 | |
| 70 | James Shields | 1025 | 1946-1958 | |
| 71 | Gary Peters | 1015 | 1946-1958 | |
| 72 | Craig Kimbrel# | 1009 | 1959-1969 | |
| 73 | Dick Drott | 998 | 1957-1969 | |
| 74 | Hal Gregg# | 976 | 1960-1969 | |
| 75 | Noah Syndergaard# | 975 | 1965-1969 | |
| 76 | Jae Weong Seo# | 959 | 1962-1969 | |
| 77 | Jim Beattie# | 958 | 1962-1969 | |
| 78 | Greg Maddux* | 954 | 1946-1957 | |
| 79 | Bob Friend | 946 | 1946-1957 | |
| 80 | Mickey Storey# | 940 | 1955-1969 | |
| 81 | Sean Newcomb | 936 | 1953-1966 | |
| 82 | Len Barker | 935 | 1946-1955 | |
| 83 | Jaret Wright# | 925 | 1961-1969 | |
| 84 | Jim Maloney | 912 | 1946-1956 | |
| 84 | Kevin Slowey | 912 | 1952-1961 | |
| 86 | Don Schwall | 907 | 1946-1959 | |
| 87 | Edinson Volquez | 900 | 1953-1966 | |
| 88 | Jim Kaat# | 897 | 1954-1969 | |
| 89 | Herb Score | 888 | 1946-1957 | |
| 89 | Al Shealy# | 888 | 1962-1969 | |
| 91 | Cory Burns | 884 | 1953-1967 | |
| 92 | Bill C Lee | 878 | 1946-1956 | |
| 93 | Dick Donovan# | 872 | 1959-1969 | |
| 94 | Mark Mulder | 869 | 1950-1961 | |
| 95 | Curt Simmons | 864 | 1955-1966 | |
| 96 | Mark Gubicza | 855 | 1947-1960 | |
| 97 | Bo Belinsky | 852 | 1949-1964 | |
| 97 | German Gonzalez | 852 | 1954-1967 | |
| 99 | Juan Marichal | 851 | 1946-1956 | |
| 100 | Cam Bedrosian# | 850 | 1953-1969 |
