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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bob O'Brien | 1999-2001 | 5 | 2 | .714 | 4.40 | 42 | 0 | 0 | 0 | 2 | 43.0 | 41 | 21 | 5 | 14 | 36 |
| Billy O'Dell | 1980-1980 | 5 | 6 | .455 | 4.95 | 19 | 13 | 1 | 0 | 0 | 91.0 | 114 | 50 | 8 | 37 | 26 |
| Ryan O'Rourke | 1982-1985 | 9 | 6 | .600 | 3.28 | 98 | 0 | 0 | 0 | 10 | 134.1 | 116 | 49 | 14 | 79 | 100 |
| Denny O'Toole | 1980-1987 | 23 | 12 | .657 | 3.32 | 278 | 0 | 0 | 0 | 16 | 388.0 | 364 | 143 | 28 | 135 | 204 |
| Jake Odorizzi | 1990-1998 | 50 | 63 | .442 | 5.49 | 200 | 135 | 22 | 4 | 3 | 991.2 | 1131 | 605 | 130 | 440 | 614 |
| Omar Olivares | 1980-1993 | 135 | 138 | .495 | 4.13 | 388 | 346 | 36 | 4 | 0 | 2469.1 | 2493 | 1132 | 262 | 734 | 1603 |
| Lester Oliveros | 1980-1984 | 13 | 8 | .619 | 4.63 | 149 | 1 | 0 | 0 | 4 | 208.0 | 219 | 107 | 19 | 103 | 117 |
| Ole Olsen | 1988-1994 | 15 | 9 | .625 | 3.90 | 180 | 18 | 0 | 0 | 2 | 328.0 | 296 | 142 | 30 | 119 | 212 |
| Scott Olsen | 1980-1983 | 15 | 21 | .417 | 4.90 | 86 | 58 | 0 | 0 | 0 | 391.0 | 418 | 213 | 46 | 186 | 228 |
| Vern Olsen | 1994-2001 | 86 | 71 | .548 | 4.52 | 235 | 218 | 18 | 5 | 0 | 1365.0 | 1362 | 685 | 143 | 545 | 1096 |
| Garrett Olson | 1989-2001 | 48 | 68 | .414 | 2.63 | 673 | 0 | 0 | 0 | 340 | 716.1 | 607 | 209 | 45 | 227 | 513 |
| Tyler Olson | 1980-1985 | 4 | 3 | .571 | 3.84 | 69 | 0 | 0 | 0 | 1 | 100.2 | 106 | 43 | 9 | 42 | 45 |
| Mike Oquist | 2001-2001 | 6 | 11 | .353 | 6.51 | 23 | 23 | 1 | 0 | 0 | 131.1 | 178 | 95 | 21 | 57 | 102 |
| Phil Ortega | 1996-2001 | 69 | 59 | .539 | 4.15 | 169 | 166 | 11 | 5 | 0 | 1115.0 | 1065 | 514 | 147 | 373 | 955 |
| Bob Osborn | 1998-1999 | 2 | 4 | .333 | 6.37 | 14 | 9 | 0 | 0 | 0 | 53.2 | 70 | 38 | 9 | 27 | 32 |
| Tiny Osborne | 1980-1987 | 53 | 82 | .393 | 4.21 | 196 | 179 | 20 | 6 | 0 | 1209.0 | 1241 | 566 | 101 | 480 | 813 |
| Bill Oster | 1986-1986 | 0 | 0 | .000 | 10.50 | 7 | 0 | 0 | 0 | 0 | 6.0 | 9 | 7 | 0 | 7 | 1 |
| Antonio Osuna | 1988-1994 | 9 | 2 | .818 | 3.84 | 97 | 0 | 0 | 0 | 5 | 136.0 | 126 | 58 | 19 | 55 | 89 |
| Roy Oswalt | 1988-2001 | 208 | 118 | .638 | 3.63 | 437 | 434 | 45 | 17 | 0 | 2940.2 | 2804 | 1186 | 288 | 819 | 2055 |
| Akinori Otsuka | 1981-1989 | 38 | 34 | .528 | 3.59 | 545 | 0 | 0 | 0 | 74 | 665.0 | 668 | 265 | 46 | 261 | 413 |
| Dave Otto | 1998-2001 | 9 | 6 | .600 | 4.74 | 107 | 0 | 0 | 0 | 15 | 133.0 | 148 | 70 | 11 | 61 | 87 |
| Stubby Overmire | 1980-1982 | 28 | 29 | .491 | 4.30 | 90 | 88 | 0 | 0 | 0 | 518.2 | 595 | 248 | 42 | 160 | 146 |
| Johan Oviedo | 1993-2000 | 17 | 22 | .436 | 6.19 | 98 | 58 | 0 | 0 | 1 | 378.0 | 430 | 260 | 57 | 213 | 250 |
