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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | John D'Acquisto# | 9.6 | 1961-1969 | |
| 2 | Darren Holmes# | 9.4 | 1957-1969 | |
| 3 | Chris Sale# | 9.2 | 1955-1969 | |
| 4 | Jimmie Keenan# | 9.0 | 1960-1969 | |
| 5 | Harry Kelley | 8.9 | 1949-1965 | |
| 6 | Noah Syndergaard# | 8.6 | 1965-1969 | |
| 7 | Dick Drott | 8.0 | 1957-1969 | |
| 8 | Bob Sebra# | 7.9 | 1959-1969 | |
| 9 | Jim Beattie# | 7.7 | 1962-1969 | |
| 10 | Pat Malone | 7.5 | 1948-1960 | |
| 10 | Cam Bedrosian# | 7.5 | 1953-1969 | |
| 12 | Mickey Storey# | 7.4 | 1955-1969 | |
| 12 | Vincent Velasquez | 7.4 | 1954-1969 | |
| 14 | Yu Darvish | 7.2 | 1950-1962 | |
| 15 | John Lackey# | 7.1 | 1960-1969 | |
| 16 | Kenta Maeda# | 7.0 | 1959-1969 | |
| 17 | Charlie Root | 6.9 | 1951-1967 | |
| 17 | Jeremy Bonderman | 6.9 | 1958-1967 | |
| 17 | Chan Ho Park | 6.9 | 1949-1966 | |
| 20 | James Paxton# | 6.8 | 1957-1969 | |
| 21 | Kirk McCaskill# | 6.7 | 1961-1969 | |
| 22 | Diego Segui# | 6.6 | 1965-1969 | |
| 23 | Hal Gregg# | 6.5 | 1960-1969 | |
| 24 | Al McBean# | 6.4 | 1962-1969 | |
| 25 | Brad Peacock | 6.2 | 1955-1967 | |
| 26 | Mace Brown# | 6.1 | 1963-1969 | |
| 26 | Tyler Anderson# | 6.1 | 1962-1969 | |
| 26 | Kevin Tapani# | 6.1 | 1961-1969 | |
| 26 | Dizzy Dean* | 6.1 | 1946-1961 | |
| 30 | Steve D Barber | 6.0 | 1953-1968 | |
| 30 | Kent Peterson# | 6.0 | 1956-1969 | |
| 30 | Arthur Rhodes | 6.0 | 1949-1963 | |
| 30 | Phil Collins# | 6.0 | 1956-1969 | |
| 34 | Hideo Nomo | 5.9 | 1948-1961 | |
| 34 | Glendon Rusch# | 5.9 | 1961-1969 | |
| 34 | Aaron Harang# | 5.9 | 1957-1969 | |
| 37 | Osiris Matos | 5.8 | 1954-1967 | |
| 37 | Jaret Wright# | 5.8 | 1961-1969 | |
| 39 | Sam Militello | 5.7 | 1956-1967 | |
| 39 | Jim Maloney | 5.7 | 1946-1956 | |
| 39 | Shawn Estes# | 5.7 | 1959-1969 | |
| 42 | Herb Score | 5.6 | 1946-1957 | |
| 42 | Freddy Garcia# | 5.6 | 1956-1969 | |
| 42 | Milt Gaston# | 5.6 | 1960-1968 | |
| 42 | Al Shealy# | 5.6 | 1962-1969 | |
| 42 | Cory Burns | 5.6 | 1953-1967 | |
| 42 | Jack Hallett | 5.6 | 1955-1969 | |
| 42 | Corey Kluber | 5.6 | 1948-1961 | |
| 49 | Madison Bumgarner* | 5.4 | 1946-1962 | |
| 49 | Tim Stauffer# | 5.4 | 1956-1969 | |
| 49 | Gary Peters | 5.4 | 1946-1958 | |
| 49 | Brad Penny# | 5.4 | 1963-1969 | |
| 49 | Ralph Birkofer# | 5.4 | 1956-1969 | |
| 49 | Dennis Rasmussen | 5.4 | 1950-1965 | |
| 55 | Dick Donovan# | 5.3 | 1959-1969 | |
| 55 | Snipe Hansen# | 5.3 | 1962-1969 | |
| 55 | David Palmer# | 5.3 | 1955-1969 | |
| 55 | Shelby Miller | 5.3 | 1953-1966 | |
| 55 | Ty Taubenheim# | 5.3 | 1952-1967 | |
| 60 | Rip Collins | 5.2 | 1953-1961 | |
| 60 | Matt Moore | 5.2 | 1946-1958 | |
| 60 | John Mitchell# | 5.2 | 1962-1969 | |
| 63 | Danny Darwin | 5.1 | 1947-1962 | |
| 63 | Mike Smithson# | 5.1 | 1961-1969 | |
| 63 | Jae Weong Seo# | 5.1 | 1962-1969 | |
| 66 | Curt Simmons | 5.0 | 1955-1966 | |
| 66 | Lefty Williams | 5.0 | 1946-1959 | |
| 66 | Eric Wilkins | 5.0 | 1954-1964 | |
| 66 | Gio Gonzalez | 5.0 | 1954-1967 | |
| 66 | Randy D Johnson | 5.0 | 1946-1951 | |
| 66 | Sean Newcomb | 5.0 | 1953-1966 | |
| 72 | Clay Buchholz# | 4.9 | 1959-1969 | |
| 72 | Paxton Crawford# | 4.9 | 1961-1969 | |
| 72 | Joe Shaute | 4.9 | 1960-1967 | |
| 72 | Francisco Cordova# | 4.9 | 1955-1969 | |
| 72 | Jon Lester | 4.9 | 1947-1966 | |
| 77 | Gabe Molina# | 4.8 | 1958-1969 | |
| 77 | Dick Pole# | 4.8 | 1957-1969 | |
| 77 | Len Barker | 4.8 | 1946-1955 | |
| 80 | Derek Lowe | 4.7 | 1950-1967 | |
| 80 | Scott Bankhead | 4.7 | 1953-1967 | |
| 80 | Bo Belinsky | 4.7 | 1949-1964 | |
| 80 | Jason Dickson# | 4.7 | 1962-1968 | |
| 80 | Kevin Slowey | 4.7 | 1952-1961 | |
| 85 | A J Griffin | 4.6 | 1949-1961 | |
| 86 | Brett Cecil | 4.5 | 1950-1969 | |
| 86 | Randy O'Neal | 4.5 | 1952-1965 | |
| 86 | Matt Clement | 4.5 | 1946-1959 | |
| 86 | Ray Culp | 4.5 | 1947-1956 | |
| 86 | Juan Marichal | 4.5 | 1946-1956 | |
| 91 | Dillon Gee | 4.4 | 1950-1966 | |
| 91 | Jason Marquis | 4.4 | 1952-1968 | |
| 91 | Scott T Baker | 4.4 | 1946-1957 | |
| 91 | Fritz Peterson# | 4.4 | 1964-1969 | |
| 95 | Toby Borland | 4.3 | 1955-1969 | |
| 95 | Jameson Taillon | 4.3 | 1950-1958 | |
| 95 | Jim Hickey# | 4.3 | 1957-1969 | |
| 95 | Bob Osborn | 4.3 | 1947-1964 | |
| 99 | Bill Monbouquette | 4.2 | 1946-1956 | |
| 99 | Reggie Cleveland | 4.2 | 1948-1966 |
