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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Frank Viola | 462 | 1946-1961 | |
| 2 | Hideo Nomo | 409 | 1948-1961 | |
| 3 | Brett Cecil | 394 | 1950-1969 | |
| 4 | Dizzy Dean* | 384 | 1946-1961 | |
| 5 | Madison Bumgarner* | 379 | 1946-1962 | |
| 6 | Charlie Root | 348 | 1951-1967 | |
| 7 | Roger Craig | 333 | 1950-1963 | |
| 8 | Arthur Rhodes | 332 | 1949-1963 | |
| 9 | Dillon Gee | 327 | 1950-1966 | |
| 10 | Lefty Williams | 325 | 1946-1959 | |
| 11 | Bob Osborn | 319 | 1947-1964 | |
| 12 | Dennis Rasmussen | 317 | 1950-1965 | |
| 13 | Phil Collins# | 307 | 1956-1969 | |
| 14 | A J Griffin | 300 | 1949-1961 | |
| 15 | James Shields | 295 | 1946-1958 | |
| 16 | Danny Darwin | 277 | 1947-1962 | |
| 17 | Tim Stauffer# | 274 | 1956-1969 | |
| 18 | Juan Pizarro | 258 | 1946-1963 | |
| 19 | Stan Coveleski | 257 | 1946-1959 | |
| 20 | Vincent Velasquez | 254 | 1954-1969 | |
| 21 | Bill Monbouquette | 251 | 1946-1956 | |
| 22 | Don Robinson | 249 | 1947-1961 | |
| 23 | Corey Kluber | 246 | 1948-1961 | |
| 24 | Larry Christenson | 243 | 1946-1961 | |
| 25 | Schoolboy Rowe | 238 | 1946-1958 | |
| 26 | Jon Lester | 237 | 1947-1966 | |
| 27 | Ed Lynch | 236 | 1948-1962 | |
| 28 | Kent Peterson# | 231 | 1956-1969 | |
| 29 | Mort Cooper | 230 | 1946-1958 | |
| 29 | Kenta Maeda# | 230 | 1959-1969 | |
| 31 | Scott T Baker | 226 | 1946-1957 | |
| 32 | Randy O'Neal | 225 | 1952-1965 | |
| 32 | Dutch Ulrich | 225 | 1954-1965 | |
| 34 | Shawn Estes# | 224 | 1959-1969 | |
| 34 | Freddy Garcia# | 224 | 1956-1969 | |
| 36 | Pat Malone | 220 | 1948-1960 | |
| 37 | Alex Fernandez | 217 | 1946-1956 | |
| 37 | Lary Sorensen# | 217 | 1956-1969 | |
| 39 | Scott Bankhead | 215 | 1953-1967 | |
| 40 | Matt Clement | 212 | 1946-1959 | |
| 40 | Yu Darvish | 212 | 1950-1962 | |
| 42 | Osiris Matos | 210 | 1954-1967 | |
| 43 | Milt Gaston# | 207 | 1960-1968 | |
| 44 | Sam Militello | 201 | 1956-1967 | |
| 45 | Jim Kaat# | 197 | 1954-1969 | |
| 46 | Francisco Cordova# | 196 | 1955-1969 | |
| 46 | Matt Moore | 196 | 1946-1958 | |
| 46 | Mike Smithson# | 196 | 1961-1969 | |
| 49 | Hugh McQuillan | 195 | 1946-1956 | |
| 50 | Shelby Miller | 193 | 1953-1966 | |
| 51 | Rip Collins | 191 | 1953-1961 | |
| 51 | Aaron Harang# | 191 | 1957-1969 | |
| 51 | Glendon Rusch# | 191 | 1961-1969 | |
| 54 | Kevin Slowey | 190 | 1952-1961 | |
| 55 | Phil Hughes | 189 | 1946-1955 | |
| 56 | Toby Borland | 186 | 1955-1969 | |
| 56 | Mike Bruhert | 186 | 1951-1968 | |
| 58 | Bill C Lee | 185 | 1946-1956 | |
| 58 | James Paxton# | 185 | 1957-1969 | |
| 60 | Rick Honeycutt | 181 | 1952-1967 | |
| 61 | Len Barker | 180 | 1946-1955 | |
| 62 | David Palmer# | 179 | 1955-1969 | |
| 62 | Curt Simmons | 179 | 1955-1966 | |
| 64 | Erv Brame | 178 | 1946-1955 | |
| 65 | Warren Hacker | 175 | 1952-1963 | |
| 65 | Don Kaiser | 175 | 1950-1964 | |
| 67 | Jeremy Bonderman | 174 | 1958-1967 | |
| 68 | Ralph Birkofer# | 173 | 1956-1969 | |
| 69 | Jim Abbott# | 172 | 1956-1965 | |
| 70 | Juan Marichal | 171 | 1946-1956 | |
| 70 | Chan Ho Park | 171 | 1949-1966 | |
| 70 | Edinson Volquez | 171 | 1953-1966 | |
| 73 | John Thomson | 169 | 1946-1957 | |
| 74 | Hod Eller | 166 | 1946-1958 | |
| 75 | Erasmo E Ramirez | 164 | 1946-1956 | |
| 76 | John Lackey# | 163 | 1960-1969 | |
| 76 | Joe Mays | 163 | 1948-1957 | |
| 78 | Mark Mulder | 162 | 1950-1961 | |
| 79 | Mark Gubicza | 161 | 1947-1960 | |
| 80 | Anthony DeSclafani | 159 | 1948-1962 | |
| 81 | Sean Newcomb | 158 | 1953-1966 | |
| 82 | Gio Gonzalez | 157 | 1954-1967 | |
| 82 | Chris Sale# | 157 | 1955-1969 | |
| 82 | Bob Sebra# | 157 | 1959-1969 | |
| 82 | Jae Weong Seo# | 157 | 1962-1969 | |
| 86 | Rex Cecil | 154 | 1961-1969 | |
| 87 | Gabe Molina# | 152 | 1958-1969 | |
| 88 | Robbie Erlin | 151 | 1947-1957 | |
| 89 | Johnny Babich | 149 | 1946-1955 | |
| 89 | Matt Wisler | 149 | 1950-1961 | |
| 91 | Ray Culp | 148 | 1947-1956 | |
| 91 | Dick Pole# | 148 | 1957-1969 | |
| 93 | Ken Holtzman | 147 | 1946-1960 | |
| 94 | Steve McCatty | 146 | 1955-1965 | |
| 95 | Jason Dickson# | 145 | 1962-1968 | |
| 95 | Syl Johnson | 145 | 1946-1958 | |
| 97 | Hiroki Kuroda | 144 | 1950-1958 | |
| 97 | Ty Taubenheim# | 144 | 1952-1967 | |
| 99 | Jameson Taillon | 143 | 1950-1958 | |
| 100 | Bob Friend | 142 | 1946-1957 |
