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| Single-Season Saves Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Saves | IP | Year | Career Leaderboard |
| 1. | Paul Assenmacher | 50 | 74.3 | 1989 | |
| Dave Smith | 50 | 73.0 | 1983 | ||
| 3. | Todd Frohwirth | 47 | 69.3 | 1989 | |
| John Franco | 47 | 78.7 | 1985 | ||
| 5. | Steve Farr | 46 | 69.3 | 1987 | |
| 6. | Jeff Russell | 43 | 81.0 | 1987 | |
| 7. | Jesse Orosco | 42 | 73.3 | 1988 | |
| Gregg Olson | 42 | 73.0 | 1988 | ||
| Dave Smith | 42 | 72.0 | 1981 | ||
| 10. | Tom Niedenfuer | 41 | 61.7 | 1987 | |
| Jeff Reardon | 41 | 68.0 | 1986 | ||
| Donnie Moore | 41 | 62.3 | 1985 | ||
| Donnie Moore | 41 | 68.3 | 1984 | ||
| Dickie Noles | 41 | 72.0 | 1982 | ||
| 15. | Dave Smith | 40 | 89.0 | 1990 | |
| Steve Farr | 40 | 76.3 | 1986 | ||
| Dave Rucker | 40 | 75.7 | 1984 | ||
| Steve Burke | 40 | 54.3 | 1984 | ||
| Gary Lucas | 40 | 74.7 | 1980 | ||
| Mark Clear | 40 | 71.7 | 1979 | ||
| 21. | Dan Schatzeder | 39 | 75.0 | 1986 | |
| Dave Rucker | 39 | 67.3 | 1986 | ||
| Danny Darwin | 39 | 80.7 | 1984 | ||
| Dave Boswell | 39 | 62.0 | 1981 | ||
| Bruce Sutter | 39 | 74.7 | 1979 | ||
| 26. | Bobby Thigpen | 38 | 81.7 | 1989 | |
| Dave Smith | 38 | 63.3 | 1989 | ||
| Norm Charlton | 38 | 65.3 | 1988 | ||
| Joe Price | 38 | 71.3 | 1987 | ||
| Dave Rucker | 38 | 60.7 | 1983 | ||
| Jesse Orosco | 38 | 113.0 | 1982 | ||
| Frank Dipino | 38 | 117.3 | 1981 | ||
| Ron Davis | 38 | 63.7 | 1979 | ||
| Mike Wallace | 38 | 60.3 | 1979 | ||
| 35. | Jeff Gray | 37 | 98.0 | 1990 | |
| Dave Rucker | 37 | 67.3 | 1988 | ||
| Mark Gubicza | 37 | 63.3 | 1988 | ||
| Gil Patterson | 37 | 69.7 | 1987 | ||
| Jim Gott | 37 | 74.0 | 1986 | ||
| Dave Smith | 37 | 71.7 | 1985 | ||
| Dave Smith | 37 | 90.0 | 1984 | ||
| Dickie Noles | 37 | 68.3 | 1983 | ||
| Bruce Sutter | 37 | 93.0 | 1980 | ||
| Mark Clear | 37 | 60.3 | 1980 | ||
| 45. | Jeff Reardon | 36 | 64.3 | 1987 | |
| Tom Niedenfuer | 36 | 51.7 | 1985 | ||
| Steve Farr | 36 | 59.7 | 1984 | ||
| Bruce Sutter | 36 | 62.0 | 1983 | ||
| Bill Zepp | 36 | 69.3 | 1979 | ||
| 50. | Dave Smith | 35 | 76.7 | 1987 | |
| Mark Littell | 35 | 70.0 | 1987 | ||
| Tom Niedenfuer | 35 | 66.7 | 1986 | ||
| Dave Smith | 35 | 64.7 | 1986 | ||
| Steve Bedrosian | 35 | 49.3 | 1986 | ||
| Dan Quisenberry | 35 | 110.3 | 1983 | ||
| Dave Smith | 35 | 70.0 | 1982 | ||
| Jesse Orosco | 35 | 119.7 | 1981 | ||
| Luis Sanchez | 35 | 61.0 | 1981 | ||
| 59. | Jesse Orosco | 34 | 125.7 | 1989 | |
| Pat Zachry | 34 | 75.7 | 1987 | ||
| Dave Rucker | 34 | 63.3 | 1987 | ||
| Dave Righetti | 34 | 97.7 | 1983 | ||
| Steve Bedrosian | 34 | 71.0 | 1983 | ||
| Roy Lee Jackson | 34 | 58.7 | 1983 | ||
| Dave Rucker | 34 | 45.7 | 1982 | ||
| Jeff Reardon | 34 | 91.0 | 1980 | ||
| Mike Stanton | 34 | 69.3 | 1980 | ||
| Dave Boswell | 34 | 63.0 | 1979 | ||
| Bob Miller | 34 | 64.3 | 1950 | ||
| 70. | Norm Charlton | 33 | 124.3 | 1990 | |
| Jeff Gray | 33 | 50.3 | 1989 | ||
| Tom Hume | 33 | 64.3 | 1988 | ||
| Roy Lee Jackson | 33 | 49.0 | 1986 | ||
| Rick Honeycutt | 33 | 77.0 | 1982 | ||
| Tom Henke | 33 | 50.3 | 1982 | ||
| Rusty Gerhardt | 33 | 58.3 | 1979 | ||
| 77. | Jeff Innis | 32 | 141.7 | 1990 | |
| Jeff Reardon | 32 | 83.3 | 1990 | ||
| Mark Gubicza | 32 | 67.0 | 1989 | ||
| Paul Assenmacher | 32 | 76.0 | 1988 | ||
| Dave Smith | 32 | 74.3 | 1988 | ||
| Dave Von Ohlen | 32 | 114.0 | 1987 | ||
| Donnie Moore | 32 | 100.0 | 1986 | ||
| Steve Farr | 32 | 66.0 | 1985 | ||
| Steve Bedrosian | 32 | 45.0 | 1985 | ||
| Jerry Reed | 32 | 59.0 | 1984 | ||
| Dan Quisenberry | 32 | 63.3 | 1982 | ||
| Bob Moose | 32 | 56.7 | 1982 | ||
| Steve Bedrosian | 32 | 55.3 | 1982 | ||
| Joe Beckwith | 32 | 119.7 | 1981 | ||
| Ron Davis | 32 | 66.7 | 1980 | ||
| Rick Camp | 32 | 63.3 | 1980 | ||
| Rick Camp | 32 | 61.7 | 1979 | ||
| 94. | Jeff Reardon | 31 | 64.7 | 1988 | |
| Jim Gott | 31 | 65.3 | 1987 | ||
| Sandy Wihtol | 31 | 107.0 | 1986 | ||
| Dave Rucker | 31 | 66.7 | 1985 | ||
| Doug Corbett | 31 | 60.7 | 1984 | ||
| Luis Deleon | 31 | 70.7 | 1983 | ||
| 100. | Frank Williams | 30 | 127.3 | 1990 | |
| Erik Hanson | 30 | 93.7 | 1990 | ||
| Pascual Perez | 30 | 85.3 | 1990 | ||
| Dave Von Ohlen | 30 | 103.0 | 1989 | ||
| Steve Bedrosian | 30 | 60.0 | 1987 | ||
| Jeff Reardon | 30 | 100.3 | 1985 | ||
| Carlos Diaz | 30 | 57.0 | 1985 | ||
| Jeff Reardon | 30 | 112.0 | 1981 | ||
| Rick Camp | 30 | 63.0 | 1981 | ||
| Dave Pagan | 30 | 124.0 | 1979 | ||
| Mike Stanton | 30 | 79.3 | 1979 | ||
| Cy Moore | 30 | 50.0 | 1932 | ||
| 112. | Mike Griffin | 29 | 111.3 | 1990 | |
| Jeff Innis | 29 | 66.3 | 1989 | ||
| Todd Frohwirth | 29 | 94.0 | 1988 | ||
| Bryan Harvey | 29 | 119.3 | 1987 | ||
| Dwayne Henry | 29 | 66.3 | 1987 | ||
| Luis Aponte | 29 | 62.0 | 1986 | ||
| Joaquin Andujar | 29 | 62.3 | 1985 | ||
| Roy Lee Jackson | 29 | 52.7 | 1985 | ||
| Jesse Orosco | 29 | 117.0 | 1983 | ||
| Jeff Reardon | 29 | 119.7 | 1982 | ||
| Bruce Berenyi | 29 | 76.3 | 1982 | ||
| Skip Guinn | 29 | 77.3 | 1980 | ||
| Dave Smith | 29 | 75.3 | 1980 | ||
| Dick Littlefield | 29 | 51.7 | 1961 | ||
| Harry Byrd | 29 | 39.3 | 1955 | ||
| 127. | Jesse Orosco | 28 | 111.3 | 1990 | |
| Cecilio Guante | 28 | 71.0 | 1989 | ||
| Roy Lee Jackson | 28 | 64.0 | 1987 | ||
| Tom Henke | 28 | 110.3 | 1985 | ||
| Jay Baller | 28 | 59.7 | 1985 | ||
| Len Barker | 28 | 116.3 | 1984 | ||
| Jeff Reardon | 28 | 72.7 | 1983 | ||
| Joaquin Andujar | 28 | 48.3 | 1983 | ||
| Danny Frisella | 28 | 66.7 | 1982 | ||
| Rick Honeycutt | 28 | 81.7 | 1981 | ||
| Bill Lee | 28 | 72.0 | 1975 | ||
| Diego Segui | 28 | 119.0 | 1967 | ||
| Tom Earley | 28 | 52.0 | 1943 | ||
| 140. | Eric Bell | 27 | 92.7 | 1990 | |
| Joe Price | 27 | 104.0 | 1988 | ||
| Mark Littell | 27 | 60.7 | 1988 | ||
| Todd Worrell | 27 | 77.3 | 1987 | ||
| Todd Worrell | 27 | 78.0 | 1985 | ||
| Mike Garman | 27 | 55.3 | 1985 | ||
| Gary Lucas | 27 | 64.3 | 1981 | ||
| Bill Zepp | 27 | 59.0 | 1981 | ||
| Woodie Fryman | 27 | 194.3 | 1968 | ||
| Hoyt Wilhelm | 27 | 99.7 | 1953 | ||
| Ed Head | 27 | 51.0 | 1942 | ||
| Harry Matuzak | 27 | 100.7 | 1936 | ||
| Belve Bean | 27 | 44.3 | 1935 | ||
| 153. | Dave Von Ohlen | 26 | 108.0 | 1990 | |
| Bryan Harvey | 26 | 120.3 | 1988 | ||
| De Wayne Buice | 26 | 66.7 | 1987 | ||
| Mike Garman | 26 | 115.3 | 1986 | ||
| Roy Lee Jackson | 26 | 36.7 | 1984 | ||
| Stan Thomas | 26 | 56.3 | 1981 | ||
| Skip Guinn | 26 | 50.7 | 1981 | ||
| Fred Breining | 26 | 107.7 | 1980 | ||
| Roy Lee Jackson | 26 | 50.0 | 1980 | ||
| Ron Cook | 26 | 128.3 | 1978 | ||
| 163. | Bryan Harvey | 25 | 105.3 | 1989 | |
| Gregg Olson | 25 | 87.0 | 1989 | ||
| Charlie Kerfeld | 25 | 74.0 | 1988 | ||
| Tom Henke | 25 | 122.7 | 1986 | ||
| Jeff Reardon | 25 | 111.0 | 1984 | ||
| Gene Nelson | 25 | 69.0 | 1984 | ||
| Rudy May | 25 | 77.0 | 1968 | ||
| Orlando Pena | 25 | 130.0 | 1963 | ||
| Bob Buhl | 25 | 95.7 | 1956 | ||
| Hoyt Wilhelm | 25 | 47.3 | 1955 | ||
| Paul Calvert | 25 | 93.3 | 1948 | ||
| Hank Johnson | 25 | 66.3 | 1938 | ||
| Mace Brown | 25 | 40.7 | 1937 | ||
| 176. | Terry Clark | 24 | 82.3 | 1990 | |
| Norm Charlton | 24 | 135.0 | 1989 | ||
| Donnie Moore | 24 | 90.3 | 1989 | ||
| Roger McDowell | 24 | 88.0 | 1989 | ||
| Tom Henke | 24 | 125.0 | 1987 | ||
| Randy Niemann | 24 | 107.7 | 1985 | ||
| Joaquin Andujar | 24 | 57.7 | 1984 | ||
| Steve Rogers | 24 | 80.0 | 1983 | ||
| Mark Clear | 24 | 137.0 | 1982 | ||
| Albert Williams | 24 | 104.3 | 1982 | ||
| Roy Lee Jackson | 24 | 43.7 | 1981 | ||
| Joaquin Andujar | 24 | 43.3 | 1981 | ||
| Randy Jones | 24 | 98.7 | 1980 | ||
| Fred Holdsworth | 24 | 78.7 | 1979 | ||
| Bobby Tiefenauer | 24 | 45.0 | 1961 | ||
| Ryne Duren | 24 | 50.0 | 1954 | ||
| Fred Sanford | 24 | 130.0 | 1949 | ||
| Vic Raschi | 24 | 45.0 | 1948 | ||
| Gordon Rhodes | 24 | 42.3 | 1933 | ||
| 195. | Gregg Olson | 23 | 104.7 | 1990 | |
| Todd Frohwirth | 23 | 88.7 | 1990 | ||
| Rusty Gerhardt | 23 | 118.7 | 1986 | ||
| Ed Correa | 23 | 38.3 | 1986 | ||
| Bob McClure | 23 | 73.7 | 1985 | ||
| Ed Glynn | 23 | 60.3 | 1985 | ||
| Chip Lang | 23 | 100.3 | 1983 | ||
| Mark Clear | 23 | 57.3 | 1983 | ||
| Joaquin Andujar | 23 | 59.0 | 1982 | ||
| Donnie Moore | 23 | 57.7 | 1979 | ||
| Catfish Hunter | 23 | 105.3 | 1972 | ||
| Mel Queen | 23 | 73.3 | 1967 | ||
| Bob Grim | 23 | 43.3 | 1962 | ||
| Bud Byerly | 23 | 49.7 | 1954 | ||
| Early Wynn | 23 | 133.7 | 1951 | ||
| Satchel Paige | 23 | 68.3 | 1948 | ||
| Johnny Humphries | 23 | 92.3 | 1947 | ||
| Johnny Murphy | 23 | 47.3 | 1940 | ||
| Gordon Rhodes | 23 | 47.0 | 1931 | ||
| 214. | Paul Assenmacher | 22 | 106.3 | 1990 | |
| Joe Price | 22 | 113.3 | 1989 | ||
| Greg Cadaret | 22 | 84.7 | 1988 | ||
| Luis Aponte | 22 | 60.7 | 1988 | ||
| Paul Assenmacher | 22 | 68.7 | 1987 | ||
| Ed Glynn | 22 | 112.3 | 1984 | ||
| Ron Schueler | 22 | 88.3 | 1981 | ||
| Len Barker | 22 | 161.7 | 1980 | ||
| Jim Slaton | 22 | 99.3 | 1980 | ||
| Billy McCool | 22 | 58.0 | 1979 | ||
| Rick Waits | 22 | 160.0 | 1978 | ||
| Buster Narum | 22 | 153.0 | 1978 | ||
| Bruce Sutter | 22 | 112.7 | 1978 | ||
| Frank Bertaina | 22 | 103.0 | 1974 | ||
| Tom Butters | 22 | 93.7 | 1968 | ||
| Sparky Lyle | 22 | 139.0 | 1967 | ||
| Diego Segui | 22 | 72.0 | 1966 | ||
| Dave Wickersham | 22 | 89.7 | 1965 | ||
| Jack Meyer | 22 | 67.7 | 1960 | ||
| Turk Farrell | 22 | 44.7 | 1960 | ||
| Tom Qualters | 22 | 87.0 | 1959 | ||
| Bob Buhl | 22 | 51.3 | 1959 | ||
| Harry Byrd | 22 | 30.3 | 1958 | ||
| Bill Kennedy | 22 | 114.7 | 1957 | ||
| Dick Littlefield | 22 | 81.7 | 1953 | ||
| Bill Kennedy | 22 | 103.3 | 1952 | ||
| Vic Raschi | 22 | 106.0 | 1947 | ||
| Hooks Iott | 22 | 60.0 | 1943 | ||
| Harry Matuzak | 22 | 90.7 | 1940 | ||
| Ray Benge | 22 | 50.7 | 1939 | ||
| Joe Sullivan | 22 | 42.7 | 1935 | ||
| Guy Cantrell | 22 | 80.0 | 1931 | ||
| Alvin Crowder | 22 | 45.0 | 1931 | ||
| 247. | Paul Assenmacher | 21 | 36.3 | 1986 | |
| Mark Littell | 21 | 95.0 | 1984 | ||
| Dave Tomlin | 21 | 77.0 | 1983 | ||
| Rick Honeycutt | 21 | 54.0 | 1983 | ||
| Bruce Sutter | 21 | 73.7 | 1982 | ||
| Bill Zepp | 21 | 42.3 | 1980 | ||
| Skip Guinn | 21 | 113.3 | 1972 | ||
| Sparky Lyle | 21 | 63.7 | 1971 | ||
| Al Hrabosky | 21 | 118.7 | 1970 | ||
| Bob Lee | 21 | 71.7 | 1969 | ||
| Terry Fox | 21 | 53.3 | 1968 | ||
| Billy Muffett | 21 | 102.0 | 1964 | ||
| Phil Paine | 21 | 83.7 | 1964 | ||
| Frank Sullivan | 21 | 91.7 | 1963 | ||
| Jack Meyer | 21 | 86.3 | 1962 | ||
| Mike Fornieles | 21 | 85.3 | 1962 | ||
| Phil Paine | 21 | 39.3 | 1962 | ||
| Don Newcombe | 21 | 140.7 | 1959 | ||
| Bud Daley | 21 | 103.7 | 1959 | ||
| Ray Crone | 21 | 92.0 | 1958 | ||
| Hoyt Wilhelm | 21 | 37.3 | 1956 | ||
| Willard Nixon | 21 | 65.7 | 1955 | ||
| Ted Wilks | 21 | 43.7 | 1951 | ||
| Dick Conger | 21 | 65.3 | 1947 | ||
| Jack Kramer | 21 | 80.7 | 1946 | ||
| Tom Ferrick | 21 | 85.0 | 1945 | ||
| Ed Head | 21 | 56.7 | 1943 | ||
| Hal Kelleher | 21 | 39.7 | 1942 | ||
| Harry Matuzak | 21 | 102.7 | 1937 | ||
| Harry Matuzak | 21 | 108.7 | 1935 | ||
| Chet Falk | 21 | 47.0 | 1935 | ||
| Jim Lindsey | 21 | 36.7 | 1931 | ||
| 279. | Brad Havens | 20 | 88.3 | 1990 | |
| George Riley | 20 | 59.3 | 1988 | ||
| Pat Zachry | 20 | 54.7 | 1986 | ||
| Gene Nelson | 20 | 79.7 | 1983 | ||
| Al Hrabosky | 20 | 105.0 | 1982 | ||
| Kent Tekulve | 20 | 67.7 | 1982 | ||
| Albert Williams | 20 | 161.7 | 1981 | ||
| Dan Quisenberry | 20 | 134.0 | 1981 | ||
| Bruce Sutter | 20 | 59.7 | 1981 | ||
| Lee Smith | 20 | 97.0 | 1980 | ||
| Hal Reniff | 20 | 157.3 | 1973 | ||
| Pete Richert | 20 | 125.3 | 1973 | ||
| Bill Stafford | 20 | 107.3 | 1972 | ||
| Bill Dailey | 20 | 97.3 | 1970 | ||
| Bob Locker | 20 | 105.7 | 1965 | ||
| Cholly Naranjo | 20 | 50.0 | 1963 | ||
| Raul Sanchez | 20 | 114.3 | 1961 | ||
| Cholly Naranjo | 20 | 47.3 | 1961 | ||
| Ted Abernathy | 20 | 71.3 | 1956 | ||
| Dick Bokelmann | 20 | 35.7 | 1953 | ||
| Hooks Iott | 20 | 44.7 | 1951 | ||
| Frank Barrett | 20 | 104.0 | 1949 |
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