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| Career Saves Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Saves | IP | Years | Single Season Leaderboard |
| 1. | Dave Smith | 410 | 820.0 | 1980-1990 | |
| 2. | Jeff Reardon | 342 | 1047.3 | 1979-1990 | |
| 3. | Dave Rucker | 257 | 624.6 | 1982-1990 | |
| 4. | Jesse Orosco | 238 | 1455.0 | 1979-1990 | |
| 5. | Donnie Moore | 222 | 1229.3 | 1975-1990 | |
| 6. | Roy Lee Jackson | 214 | 676.0 | 1977-1988 | |
| 7. | Harry Matuzak | 207 | 909.6 | 1934-1945 | |
| 8. | Bruce Sutter | 202 | 631.3 | 1976-1984 | |
| 9. | Al Hrabosky | 188 | 1497.6 | 1970-1984 | |
| 10. | Tom Henke | 184 | 1010.6 | 1982-1990 | |
| 11. | Hooks Iott | 179 | 738.3 | 1941-1955 | |
| 12. | Steve Farr | 178 | 521.3 | 1984-1990 | |
| 13. | Steve Bedrosian | 173 | 858.3 | 1982-1990 | |
| 14. | Skip Guinn | 168 | 923.0 | 1969-1982 | |
| 15. | Mark Clear | 163 | 780.0 | 1979-1990 | |
| 16. | Bill Dailey | 154 | 1186.3 | 1961-1971 | |
| 17. | Paul Assenmacher | 147 | 361.7 | 1986-1990 | |
| 18. | Joaquin Andujar | 145 | 535.6 | 1978-1988 | |
| Al Benton | 145 | 653.3 | 1934-1944 | ||
| 20. | Guy Cantrell | 143 | 779.0 | 1930-1943 | |
| 21. | Bobby Tiefenauer | 141 | 953.3 | 1952-1967 | |
| 22. | Ron Davis | 136 | 939.9 | 1978-1990 | |
| 23. | Dan Quisenberry | 134 | 745.7 | 1979-1988 | |
| 24. | Bill Kennedy | 132 | 864.6 | 1948-1958 | |
| 25. | Diego Segui | 131 | 831.3 | 1962-1973 | |
| 26. | Bill Zepp | 130 | 1012.6 | 1969-1983 | |
| Bob Grim | 130 | 754.6 | 1954-1965 | ||
| 28. | Rusty Gerhardt | 128 | 1594.6 | 1974-1988 | |
| 29. | Ed Glynn | 124 | 1010.0 | 1978-1988 | |
| 30. | Tom Niedenfuer | 122 | 488.0 | 1982-1990 | |
| 31. | Mike Garman | 120 | 2479.6 | 1971-1989 | |
| 32. | Cecilio Guante | 118 | 719.3 | 1982-1990 | |
| 33. | Hal Reniff | 117 | 2757.9 | 1962-1978 | |
| 34. | Dave Boswell | 114 | 2578.3 | 1965-1982 | |
| 35. | Joe Price | 112 | 604.7 | 1982-1990 | |
| 36. | Mark Littell | 110 | 1755.3 | 1973-1990 | |
| Don Mossi | 110 | 1162.6 | 1954-1964 | ||
| 38. | Dave Von Ohlen | 107 | 581.0 | 1985-1990 | |
| Jack Meyer | 107 | 1444.3 | 1955-1968 | ||
| 40. | Rick Camp | 106 | 1158.6 | 1978-1988 | |
| Randy Jones | 106 | 1251.0 | 1973-1986 | ||
| Ed Head | 106 | 2688.0 | 1940-1956 | ||
| 43. | Phil Paine | 105 | 352.3 | 1951-1966 | |
| 44. | Archie McKain | 100 | 834.0 | 1937-1947 | |
| 45. | Todd Frohwirth | 99 | 252.0 | 1988-1990 | |
| Ron Taylor | 99 | 1206.9 | 1963-1976 | ||
| 47. | Todd Worrell | 97 | 572.7 | 1985-1990 | |
| Hal Kelleher | 97 | 613.0 | 1937-1947 | ||
| 49. | Sam Jones | 96 | 1258.3 | 1951-1964 | |
| 50. | Bryan Harvey | 95 | 444.0 | 1987-1990 | |
| Norm Charlton | 95 | 324.7 | 1988-1990 | ||
| Harry Byrd | 95 | 751.3 | 1952-1960 | ||
| Cy Moore | 95 | 624.0 | 1930-1939 | ||
| 54. | Hoyt Wilhelm | 94 | 568.3 | 1952-1958 | |
| 55. | Bob Blaylock | 93 | 744.0 | 1956-1969 | |
| Raul Sanchez | 93 | 1435.3 | 1955-1968 | ||
| Dick Littlefield | 93 | 849.6 | 1951-1963 | ||
| Gordon Rhodes | 93 | 309.3 | 1930-1940 | ||
| 59. | Mark Gubicza | 92 | 1080.0 | 1984-1990 | |
| Pat Zachry | 92 | 1315.6 | 1976-1988 | ||
| Sparky Lyle | 92 | 1045.0 | 1967-1975 | ||
| Dick Conger | 92 | 535.0 | 1943-1955 | ||
| 63. | Chief Hogsett | 91 | 982.0 | 1930-1940 | |
| 64. | Luis Aponte | 90 | 885.3 | 1980-1990 | |
| Gregg Olson | 90 | 264.7 | 1988-1990 | ||
| Gary Lucas | 90 | 560.0 | 1980-1988 | ||
| 67. | Rick Honeycutt | 89 | 502.7 | 1979-1986 | |
| Paul Calvert | 89 | 540.6 | 1944-1952 | ||
| 69. | Jack Kramer | 87 | 2332.0 | 1942-1956 | |
| 70. | Vic Raschi | 85 | 863.0 | 1946-1956 | |
| 71. | Jim Owens | 83 | 1634.3 | 1955-1969 | |
| Tom Butters | 83 | 750.6 | 1962-1969 | ||
| Pretzel Pezzullo | 83 | 375.0 | 1939-1946 | ||
| 74. | Bob Buhl | 82 | 957.0 | 1953-1961 | |
| 75. | Dickie Noles | 81 | 1453.3 | 1979-1990 | |
| 76. | Tony Pierce | 80 | 609.9 | 1967-1981 | |
| Mike Fornieles | 80 | 1129.3 | 1952-1965 | ||
| Sandy Consuegra | 80 | 594.3 | 1945-1955 | ||
| 79. | Mike Stanton | 79 | 927.3 | 1975-1981 | |
| Dennis Bennett | 79 | 1297.6 | 1963-1975 | ||
| Jay Ritchie | 79 | 823.7 | 1964-1975 | ||
| 82. | Kent Tekulve | 78 | 694.6 | 1974-1985 | |
| Tom Qualters | 78 | 3989.9 | 1954-1973 | ||
| Roger Bowman | 78 | 1935.3 | 1949-1962 | ||
| 85. | Sandy Wihtol | 77 | 733.6 | 1979-1990 | |
| Ron Cook | 77 | 1701.6 | 1970-1983 | ||
| 87. | Rick Sutcliffe | 76 | 1142.0 | 1978-1990 | |
| Jeff Gray | 76 | 193.7 | 1988-1990 | ||
| Hal Kurtz | 76 | 895.3 | 1969-1980 | ||
| Camilo Pascual | 76 | 2222.3 | 1954-1969 | ||
| Sid Hudson | 76 | 786.3 | 1940-1946 | ||
| 92. | Buster Narum | 75 | 1755.6 | 1969-1980 | |
| 93. | Don Wilson | 74 | 1501.3 | 1969-1980 | |
| Terry Fox | 74 | 439.3 | 1960-1969 | ||
| 95. | Brian Holton | 72 | 668.0 | 1985-1990 | |
| Rob Gardner | 72 | 1521.6 | 1969-1981 | ||
| Mace Brown | 72 | 805.0 | 1935-1943 | ||
| 98. | Dave Tomlin | 71 | 947.0 | 1972-1983 | |
| 99. | Bobby Thigpen | 70 | 242.6 | 1988-1990 | |
| 100. | John Franco | 69 | 899.3 | 1984-1990 | |
| Jeff Innis | 69 | 233.3 | 1987-1990 | ||
| Chris Zachary | 69 | 1204.6 | 1963-1979 | ||
| 103. | Carlos Diaz | 68 | 730.3 | 1982-1990 | |
| Jim Gott | 68 | 620.0 | 1982-1987 | ||
| Jim Lindsey | 68 | 253.3 | 1930-1935 | ||
| 106. | Clyde Shoun | 67 | 616.6 | 1936-1944 | |
| Belve Bean | 67 | 608.0 | 1930-1939 | ||
| 108. | Darold Knowles | 66 | 608.0 | 1965-1974 | |
| Ron Piche | 66 | 467.7 | 1960-1968 | ||
| Johnny Murphy | 66 | 1378.6 | 1932-1942 | ||
| 111. | Dan Schatzeder | 65 | 382.7 | 1983-1988 | |
| John Miller | 65 | 1633.0 | 1963-1978 | ||
| 113. | Whitey Wilshere | 64 | 1936.6 | 1934-1947 | |
| Hank Johnson | 64 | 568.6 | 1930-1938 | ||
| Ken Ash | 64 | 505.3 | 1930-1937 | ||
| 116. | Len Barker | 63 | 1282.3 | 1978-1987 | |
| Dave Ferriss | 63 | 2979.3 | 1945-1958 | ||
| 118. | Cholly Naranjo | 62 | 243.3 | 1960-1966 | |
| Ted Abernathy | 62 | 566.0 | 1955-1964 | ||
| 120. | Dwayne Henry | 61 | 666.3 | 1986-1990 | |
| Fred Holdsworth | 61 | 1320.0 | 1974-1987 | ||
| Billy McCool | 61 | 2417.6 | 1964-1981 | ||
| Bill Stafford | 61 | 853.6 | 1963-1972 | ||
| 124. | Chuck Hartenstein | 60 | 504.3 | 1970-1977 | |
| Bob Wiesler | 60 | 428.0 | 1952-1963 | ||
| 126. | Bill Bonham | 59 | 1632.3 | 1972-1982 | |
| Eddie Fisher | 59 | 2202.3 | 1961-1972 | ||
| Bob Locker | 59 | 972.6 | 1965-1972 | ||
| Orlando Pena | 59 | 1281.6 | 1958-1970 | ||
| Tom Ferrick | 59 | 507.0 | 1941-1947 | ||
| Chet Falk | 59 | 591.3 | 1930-1941 | ||
| 132. | Larry Andersen | 58 | 469.6 | 1975-1985 | |
| Larry Dierker | 58 | 1704.3 | 1964-1978 | ||
| Danny Coombs | 58 | 782.6 | 1968-1978 | ||
| Jack Aker | 58 | 302.3 | 1964-1972 | ||
| Bob Duliba | 58 | 405.0 | 1959-1969 | ||
| Bud Byerly | 58 | 2064.6 | 1944-1955 | ||
| Johnny Humphries | 58 | 767.0 | 1939-1949 | ||
| 139. | Gil Patterson | 57 | 916.0 | 1977-1988 | |
| Steve Burke | 57 | 141.0 | 1982-1987 | ||
| Bob Moose | 57 | 2121.0 | 1968-1983 | ||
| Ray Lamb | 57 | 946.0 | 1969-1977 | ||
| Lefty West | 57 | 529.3 | 1944-1950 | ||
| Bud Tinning | 57 | 371.6 | 1932-1939 | ||
| 145. | Dave Righetti | 56 | 1550.3 | 1981-1990 | |
| Brad Havens | 56 | 674.0 | 1983-1990 | ||
| Frank Dipino | 56 | 709.0 | 1981-1989 | ||
| Howie Nunn | 56 | 2499.3 | 1959-1973 | ||
| Jackie Collum | 56 | 2297.0 | 1951-1964 | ||
| 150. | Craig Swan | 55 | 809.3 | 1975-1985 | |
| Bill Lee | 55 | 2689.3 | 1969-1984 | ||
| Steve Rogers | 55 | 1995.0 | 1973-1984 | ||
| Joe Hoerner | 55 | 2836.0 | 1963-1976 | ||
| Don Lee | 55 | 914.0 | 1960-1968 | ||
| Turk Farrell | 55 | 595.6 | 1956-1964 | ||
| Junior Thompson | 55 | 1172.3 | 1940-1952 | ||
| 157. | Pete Mikkelsen | 54 | 935.6 | 1964-1977 | |
| Dick Radatz | 54 | 550.3 | 1962-1970 | ||
| Herman Starrette | 54 | 378.7 | 1963-1967 | ||
| Walt Masterson | 54 | 3778.6 | 1941-1959 | ||
| Al Aber | 54 | 634.0 | 1950-1959 | ||
| 162. | Russ Kemmerer | 53 | 2007.0 | 1954-1968 | |
| Ken Johnson | 53 | 658.6 | 1948-1957 | ||
| Fred Martin | 53 | 631.0 | 1946-1950 | ||
| 165. | Randy Niemann | 52 | 650.3 | 1979-1989 | |
| Albert Williams | 52 | 396.0 | 1981-1985 | ||
| Pete Richert | 52 | 2253.7 | 1965-1975 | ||
| Moe Drabowsky | 52 | 1868.6 | 1958-1971 | ||
| Dick Bokelmann | 52 | 320.3 | 1951-1960 | ||
| 170. | Bruce Berenyi | 51 | 543.7 | 1980-1985 | |
| Skip Lockwood | 51 | 809.0 | 1969-1981 | ||
| Jim Coates | 51 | 577.0 | 1956-1968 | ||
| Ralph Judd | 51 | 313.7 | 1930-1937 | ||
| 174. | Ernie Camacho | 50 | 462.6 | 1980-1987 | |
| Mike Wallace | 50 | 487.0 | 1975-1983 | ||
| Catfish Hunter | 50 | 1280.6 | 1970-1981 | ||
| Dick Estelle | 50 | 1127.0 | 1969-1979 | ||
| Dick Drott | 50 | 2845.9 | 1959-1974 | ||
| Leo Kiely | 50 | 3966.9 | 1951-1967 | ||
| Jim Hearn | 50 | 731.3 | 1947-1957 | ||
| Joe Page | 50 | 1245.0 | 1944-1950 | ||
| Bob Joyce | 50 | 947.3 | 1940-1950 | ||
| 183. | Frank Williams | 49 | 1147.3 | 1984-1990 | |
| Tom Hume | 49 | 921.3 | 1977-1989 | ||
| Doug Corbett | 49 | 612.3 | 1980-1987 | ||
| Tug McGraw | 49 | 3032.0 | 1965-1981 | ||
| Bob Reynolds | 49 | 2052.3 | 1969-1981 | ||
| Sam McDowell | 49 | 1993.6 | 1961-1980 | ||
| Frank Bertaina | 49 | 1255.7 | 1969-1979 | ||
| Jose Santiago | 49 | 573.6 | 1963-1973 | ||
| Don Larsen | 49 | 2619.3 | 1953-1968 | ||
| Clem Labine | 49 | 485.6 | 1950-1959 | ||
| Dave Koslo | 49 | 2550.3 | 1941-1953 | ||
| Joe Bowman | 49 | 1788.3 | 1932-1946 | ||
| 195. | Jamie Easterly | 48 | 1434.3 | 1974-1990 | |
| Rick Waits | 48 | 1303.6 | 1976-1986 | ||
| Rawly Eastwick | 48 | 981.6 | 1974-1982 | ||
| Phil Niekro | 48 | 2036.6 | 1964-1975 | ||
| Tom Burgmeier | 48 | 382.6 | 1968-1975 | ||
| Glen Hobbie | 48 | 1615.3 | 1957-1969 | ||
| Billy Muffett | 48 | 869.6 | 1957-1966 | ||
| Bob Miller | 48 | 3445.6 | 1949-1964 | ||
| Ed Albosta | 48 | 247.0 | 1950-1955 | ||
| Don Brennan | 48 | 289.7 | 1933-1938 | ||
| 205. | Gene Nelson | 47 | 378.6 | 1983-1990 | |
| Dave Pagan | 47 | 2237.6 | 1973-1987 | ||
| Tommie Sisk | 47 | 944.3 | 1965-1975 | ||
| Joe Grzenda | 47 | 374.3 | 1961-1965 | ||
| Alex Carrasquel | 47 | 630.6 | 1940-1948 | ||
| Frank Lamanna | 47 | 224.0 | 1943-1948 | ||
| 211. | Dick Selma | 46 | 2703.6 | 1965-1980 | |
| Fritz Peterson | 46 | 940.3 | 1967-1978 | ||
| Ed Rakow | 46 | 704.6 | 1960-1970 | ||
| Clay Smith | 46 | 272.0 | 1939-1947 | ||
| 215. | Jim Merritt | 45 | 1213.6 | 1966-1978 | |
| Joe Schaffernoth | 45 | 1328.6 | 1963-1973 | ||
| Dale Willis | 45 | 357.3 | 1963-1972 | ||
| Nelson Chittum | 45 | 651.3 | 1958-1967 | ||
| Ed Baecht | 45 | 2720.3 | 1930-1943 | ||
| Dick Coffman | 45 | 1007.0 | 1930-1942 | ||
| Leon Chagnon | 45 | 821.3 | 1930-1939 | ||
| 222. | Al Holland | 44 | 1001.0 | 1977-1988 | |
| Lynn McGlothen | 44 | 1719.9 | 1972-1986 | ||
| Ron Tompkins | 44 | 540.0 | 1971-1980 | ||
| Al Jackson | 44 | 2660.9 | 1959-1974 | ||
| Dean Stone | 44 | 2641.0 | 1954-1967 | ||
| Lee Stine | 44 | 1283.9 | 1938-1950 | ||
| 228. | Jeff Russell | 43 | 1265.3 | 1983-1990 | |
| Ed Halicki | 43 | 2535.6 | 1974-1989 | ||
| Bob Kuzava | 43 | 2152.6 | 1947-1958 | ||
| Roy Bruner | 43 | 631.3 | 1942-1952 | ||
| Johnny Gee | 43 | 1118.0 | 1939-1951 | ||
| Bill Crouch | 43 | 244.3 | 1939-1942 | ||
| Lefty Willis | 43 | 1092.0 | 1930-1940 | ||
| 235. | Danny Darwin | 42 | 2718.6 | 1978-1990 | |
| Ken Wright | 42 | 586.0 | 1971-1981 | ||
| Jim Palmer | 42 | 2309.9 | 1967-1980 | ||
| Dave Wickersham | 42 | 2316.6 | 1961-1971 | ||
| Jim Hannan | 42 | 319.0 | 1964-1971 | ||
| Rex Barney | 42 | 760.6 | 1945-1958 | ||
| Bob Harris | 42 | 1204.0 | 1945-1955 | ||
| Joe Sullivan | 42 | 287.6 | 1935-1942 | ||
| Dennis Burns | 42 | 249.7 | 1930-1933 | ||
| 244. | Mike Griffin | 41 | 2004.3 | 1979-1990 | |
| Jay Baller | 41 | 247.0 | 1984-1990 | ||
| Larry Bradford | 41 | 471.0 | 1977-1983 | ||
| Bob Anderson | 41 | 1646.3 | 1957-1970 | ||
| Jim Duffalo | 41 | 379.0 | 1965-1969 | ||
| Don Gross | 41 | 1195.3 | 1955-1966 | ||
| Howie Pollet | 41 | 3424.9 | 1941-1958 | ||
| Arnie Portocarrero | 41 | 764.0 | 1954-1958 | ||
| Jack Banta | 41 | 455.6 | 1947-1957 | ||
| Fred Sanford | 41 | 1018.0 | 1945-1952 | ||
| Mel Harder | 41 | 689.0 | 1931-1941 | ||
| Russ Van Atta | 41 | 304.0 | 1933-1937 | ||
| 256. | Joe Beckwith | 40 | 2097.6 | 1979-1990 | |
| Joe Klink | 40 | 368.3 | 1987-1990 | ||
| De Wayne Buice | 40 | 192.3 | 1987-1989 | ||
| Phil Hennigan | 40 | 1679.3 | 1971-1985 | ||
| Jim Maloney | 40 | 3052.9 | 1961-1977 | ||
| Sammy Ellis | 40 | 1466.3 | 1965-1974 | ||
| Ron Moeller | 40 | 315.6 | 1967-1973 | ||
| Seth Morehead | 40 | 2429.6 | 1957-1969 | ||
| Duke Maas | 40 | 329.0 | 1955-1963 | ||
| Tom Earley | 40 | 556.3 | 1942-1950 | ||
| 266. | Charlie Kerfeld | 39 | 618.3 | 1985-1990 | |
| Danny Frisella | 39 | 2516.6 | 1968-1982 | ||
| Doug Bair | 39 | 561.3 | 1976-1981 | ||
| Willard Nixon | 39 | 1320.3 | 1950-1961 | ||
| Early Wynn | 39 | 2136.6 | 1939-1954 | ||
| Syd Cohen | 39 | 422.0 | 1934-1942 | ||
| 272. | Kevin Saucier | 38 | 415.3 | 1982-1989 | |
| Jerry Reed | 38 | 262.3 | 1983-1988 | ||
| Dave Giusti | 38 | 2284.6 | 1962-1973 | ||
| Woodie Fryman | 38 | 1144.0 | 1966-1973 | ||
| Bob Lee | 38 | 231.6 | 1964-1973 | ||
| Claude Raymond | 38 | 427.0 | 1959-1968 | ||
| Eddie Erautt | 38 | 425.3 | 1947-1954 | ||
| Jack Hallett | 38 | 2128.3 | 1940-1950 | ||
| Claude Passeau | 38 | 2696.3 | 1935-1948 | ||
| 281. | Ken Frailing | 37 | 938.0 | 1973-1983 | |
| Jim Shellenback | 37 | 1743.0 | 1967-1981 | ||
| Juan Pizarro | 37 | 668.0 | 1959-1970 | ||
| Charley Schanz | 37 | 2637.6 | 1944-1955 | ||
| Nick Strincevich | 37 | 313.6 | 1940-1947 | ||
| 286. | Luis Sanchez | 36 | 76.7 | 1981-1983 | |
| Dan Schneider | 36 | 1560.3 | 1969-1979 | ||
| Bob Miller | 36 | 727.3 | 1957-1966 | ||
| Ray Narleski | 36 | 367.0 | 1954-1964 | ||
| Hal Manders | 36 | 1053.3 | 1943-1952 | ||
| Lon Warneke | 36 | 2067.6 | 1930-1942 | ||
| Bob Brown | 36 | 611.7 | 1930-1939 | ||
| Alvin Crowder | 36 | 99.0 | 1930-1931 | ||
| 294. | John Morris | 35 | 2477.3 | 1966-1980 | |
| Denny McLain | 35 | 2567.0 | 1963-1979 | ||
| Ken Sanders | 35 | 1873.3 | 1964-1976 | ||
| Dave Hillman | 35 | 982.6 | 1955-1965 | ||
| Bob Porterfield | 35 | 914.9 | 1948-1959 | ||
| Gerry Staley | 35 | 367.7 | 1947-1953 | ||
| Bill Sayles | 35 | 2124.0 | 1939-1951 |
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