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| Second Basemen Single-Season Homeruns Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Homeruns | PA | Year | Career Leaderboard |
| 1. | Gil McDougald * | 50 | 678 | 1958 | |
| 2. | Don Demeter | 41 | 607 | 1961 | |
| 3. | Don Demeter | 36 | 616 | 1959 | |
| Gil McDougald * | 36 | 682 | 1957 | ||
| 5. | Gil McDougald * | 35 | 672 | 1961 | |
| Gil McDougald * | 35 | 613 | 1959 | ||
| 7. | Gil McDougald * | 34 | 657 | 1952 | |
| Joe Gordon | 34 | 605 | 1942 | ||
| 9. | Don Demeter | 33 | 619 | 1960 | |
| Joe Gordon | 33 | 598 | 1941 | ||
| 11. | Don Demeter | 32 | 646 | 1967 | |
| Gil McDougald * | 32 | 701 | 1956 | ||
| Gil McDougald * | 32 | 674 | 1954 | ||
| Hank Thompson | 32 | 503 | 1952 | ||
| Tony Lazzeri * | 32 | 656 | 1937 | ||
| 16. | Gil McDougald * | 31 | 635 | 1960 | |
| Hank Thompson | 31 | 606 | 1960 | ||
| Hank Thompson | 31 | 595 | 1959 | ||
| 19. | Lou Whitaker | 30 | 681 | 1987 | |
| Greg Luzinski | 30 | 677 | 1981 | ||
| Hank Thompson | 30 | 616 | 1958 | ||
| Grady Hatton | 30 | 693 | 1949 | ||
| 23. | Greg Luzinski | 29 | 646 | 1973 | |
| Don Demeter | 29 | 626 | 1962 | ||
| 25. | Gary Geiger | 28 | 668 | 1963 | |
| Hank Thompson | 28 | 637 | 1955 | ||
| Grady Hatton | 28 | 666 | 1947 | ||
| Grady Hatton | 28 | 667 | 1946 | ||
| 29. | Greg Luzinski | 27 | 637 | 1982 | |
| Willie Horton | 27 | 654 | 1970 | ||
| Gary Geiger | 27 | 614 | 1967 | ||
| Don Demeter | 27 | 635 | 1963 | ||
| Hank Thompson | 27 | 602 | 1956 | ||
| Gil McDougald * | 27 | 662 | 1953 | ||
| 35. | Greg Luzinski | 26 | 669 | 1984 | |
| Gil McDougald * | 26 | 649 | 1962 | ||
| Gil McDougald * | 26 | 627 | 1955 | ||
| Grady Hatton | 26 | 689 | 1952 | ||
| Sherry Robertson | 26 | 481 | 1952 | ||
| Tony Lazzeri * | 26 | 635 | 1931 | ||
| 41. | Greg Luzinski | 25 | 666 | 1986 | |
| Greg Luzinski | 25 | 644 | 1983 | ||
| Greg Luzinski | 25 | 644 | 1974 | ||
| Willie Horton | 25 | 687 | 1971 | ||
| Gil McDougald * | 25 | 621 | 1963 | ||
| Hank Thompson | 25 | 627 | 1957 | ||
| Grady Hatton | 25 | 687 | 1953 | ||
| 48. | Lou Whitaker | 24 | 661 | 1990 | |
| Lou Whitaker | 24 | 681 | 1983 | ||
| Nelson Mathews | 24 | 557 | 1972 | ||
| Gary Geiger | 24 | 619 | 1970 | ||
| Don Demeter | 24 | 566 | 1969 | ||
| Gary Geiger | 24 | 577 | 1966 | ||
| Grady Hatton | 24 | 708 | 1950 | ||
| Tony Lazzeri * | 24 | 608 | 1935 | ||
| 56. | Paul Molitor | 23 | 655 | 1990 | |
| Paul Molitor | 23 | 645 | 1988 | ||
| Greg Luzinski | 23 | 658 | 1977 | ||
| Johnny Goryl | 23 | 581 | 1966 | ||
| Sherry Robertson | 23 | 442 | 1951 | ||
| Jimmie Dykes | 23 | 670 | 1930 | ||
| 62. | Lou Whitaker | 22 | 656 | 1986 | |
| Paul Molitor | 22 | 657 | 1984 | ||
| Ryne Sandberg | 22 | 558 | 1984 | ||
| Lou Whitaker | 22 | 660 | 1982 | ||
| Greg Luzinski | 22 | 577 | 1980 | ||
| Willie Horton | 22 | 644 | 1972 | ||
| Joe Morgan | 22 | 711 | 1971 | ||
| Don Demeter | 22 | 531 | 1968 | ||
| Willie Horton | 22 | 596 | 1966 | ||
| Don Demeter | 22 | 481 | 1964 | ||
| Ted Lepcio | 22 | 558 | 1954 | ||
| Hank Thompson | 22 | 576 | 1953 | ||
| Pee Wee Reese * | 22 | 669 | 1951 | ||
| Alex Kampouris | 22 | 648 | 1944 | ||
| 76. | Jorge Orta | 21 | 580 | 1982 | |
| Willie Horton | 21 | 655 | 1969 | ||
| Joe Morgan | 21 | 710 | 1966 | ||
| Don Demeter | 21 | 555 | 1966 | ||
| Nelson Mathews | 21 | 590 | 1965 | ||
| Don Demeter | 21 | 380 | 1965 | ||
| Grady Hatton | 21 | 703 | 1951 | ||
| Joe Gordon | 21 | 524 | 1944 | ||
| 84. | Greg Luzinski | 20 | 663 | 1979 | |
| Bobby Grich | 20 | 689 | 1975 | ||
| Greg Luzinski | 20 | 507 | 1975 | ||
| Gary Geiger | 20 | 635 | 1969 | ||
| Johnny Goryl | 20 | 423 | 1969 | ||
| Willie Horton | 20 | 594 | 1967 | ||
| Gary Geiger | 20 | 634 | 1965 | ||
| Hank Thompson | 20 | 649 | 1954 | ||
| Bobby Avila | 20 | 688 | 1953 | ||
| Hank Thompson | 20 | 487 | 1950 | ||
| Sherry Robertson | 20 | 429 | 1950 | ||
| 95. | Ryne Sandberg | 19 | 633 | 1989 | |
| Paul Molitor | 19 | 688 | 1987 | ||
| Lou Whitaker | 19 | 457 | 1984 | ||
| Greg Luzinski | 19 | 664 | 1978 | ||
| Joe Morgan | 19 | 626 | 1974 | ||
| Nelson Mathews | 19 | 346 | 1971 | ||
| Joe Morgan | 19 | 712 | 1970 | ||
| Nelson Mathews | 19 | 446 | 1970 | ||
| Nelson Mathews | 19 | 592 | 1966 | ||
| Gary Geiger | 19 | 530 | 1962 | ||
| Ted Lepcio | 19 | 398 | 1955 | ||
| Bobby Avila | 19 | 691 | 1954 | ||
| Gil McDougald * | 19 | 542 | 1951 | ||
| Tony Lazzeri * | 19 | 630 | 1932 | ||
| 109. | Ryne Sandberg | 18 | 651 | 1990 | |
| Ryne Sandberg | 18 | 623 | 1985 | ||
| Greg Luzinski | 18 | 664 | 1976 | ||
| Jorge Orta | 18 | 556 | 1976 | ||
| Marty Martinez | 18 | 535 | 1975 | ||
| Willie Horton | 18 | 680 | 1973 | ||
| Nelson Mathews | 18 | 576 | 1968 | ||
| Ted Lepcio | 18 | 417 | 1964 | ||
| Lee Walls | 18 | 690 | 1963 | ||
| Johnny Goryl | 18 | 597 | 1963 | ||
| Jim Davenport | 18 | 554 | 1963 | ||
| Johnny Goryl | 18 | 588 | 1961 | ||
| Hank Thompson | 18 | 500 | 1951 | ||
| Joe Gordon | 18 | 532 | 1940 | ||
| Tony Lazzeri * | 18 | 641 | 1938 | ||
| Tony Lazzeri * | 18 | 615 | 1933 | ||
| Max Bishop | 18 | 697 | 1931 | ||
| 126. | Bump Wills | 17 | 620 | 1978 | |
| Joe Morgan | 17 | 689 | 1972 | ||
| Nelson Mathews | 17 | 502 | 1969 | ||
| Charley Smith | 17 | 437 | 1968 | ||
| Don Buddin | 17 | 434 | 1968 | ||
| Lee Walls | 17 | 655 | 1967 | ||
| Lee Walls | 17 | 672 | 1966 | ||
| Johnny Goryl | 17 | 570 | 1965 | ||
| Johnny Goryl | 17 | 575 | 1964 | ||
| Gene Stephens | 17 | 555 | 1957 | ||
| Tommy Glaviano | 17 | 666 | 1951 | ||
| Pee Wee Reese * | 17 | 724 | 1950 | ||
| Tony Lazzeri * | 17 | 622 | 1934 | ||
| Rogers Hornsby | 17 | 678 | 1930 | ||
| 140. | Juan Samuel | 16 | 614 | 1990 | |
| Lou Whitaker | 16 | 545 | 1989 | ||
| Kevin Elster | 16 | 532 | 1989 | ||
| Kevin Elster | 16 | 488 | 1988 | ||
| Lou Whitaker | 16 | 610 | 1985 | ||
| Jim Lefebvre | 16 | 548 | 1974 | ||
| Rod Carew | 16 | 618 | 1973 | ||
| Greg Luzinski | 16 | 612 | 1972 | ||
| Charley Smith | 16 | 548 | 1971 | ||
| Johnny Goryl | 16 | 560 | 1968 | ||
| Gary Geiger | 16 | 485 | 1968 | ||
| Ted Lepcio | 16 | 358 | 1963 | ||
| Lee Walls | 16 | 630 | 1959 | ||
| Roy Hartsfield | 16 | 634 | 1958 | ||
| Lee Walls | 16 | 624 | 1957 | ||
| Don Zimmer | 16 | 615 | 1957 | ||
| Hank Thompson | 16 | 510 | 1949 | ||
| Hank Thompson | 16 | 515 | 1948 | ||
| Alex Kampouris | 16 | 682 | 1943 | ||
| Stan Hack | 16 | 714 | 1942 | ||
| Jimmie Dykes | 16 | 581 | 1932 | ||
| Jimmie Dykes | 16 | 576 | 1931 | ||
| 162. | Ryne Sandberg | 15 | 631 | 1987 | |
| Paul Molitor | 15 | 670 | 1986 | ||
| Bump Wills | 15 | 483 | 1986 | ||
| Jorge Orta | 15 | 570 | 1985 | ||
| Cal Ripken Jr. | 15 | 386 | 1984 | ||
| Ryne Sandberg | 15 | 534 | 1982 | ||
| Jorge Orta | 15 | 621 | 1981 | ||
| Jorge Orta | 15 | 663 | 1980 | ||
| Willie Horton | 15 | 602 | 1978 | ||
| Bobby Grich | 15 | 699 | 1977 | ||
| Bobby Grich | 15 | 643 | 1973 | ||
| Joe Morgan | 15 | 611 | 1973 | ||
| Charley Smith | 15 | 581 | 1970 | ||
| Joe Morgan | 15 | 717 | 1969 | ||
| Gary Geiger | 15 | 583 | 1964 | ||
| Don Buddin | 15 | 452 | 1959 | ||
| Tommy Glaviano | 15 | 679 | 1958 | ||
| Don Demeter | 15 | 306 | 1958 | ||
| Billy Cox | 15 | 677 | 1952 | ||
| Lou Stringer | 15 | 660 | 1951 | ||
| Johnny Bero | 15 | 526 | 1949 | ||
| Sherry Robertson | 15 | 454 | 1949 | ||
| Pee Wee Reese * | 15 | 698 | 1946 | ||
| Jim Bucher | 15 | 529 | 1944 | ||
| Tony Lazzeri * | 15 | 661 | 1936 | ||
| Max Bishop | 15 | 645 | 1933 | ||
| George Grantham | 15 | 669 | 1931 | ||
| Stu Clarke | 15 | 586 | 1931 | ||
| Bob Barrett | 15 | 639 | 1930 | ||
| 191. | Kevin Elster | 14 | 507 | 1990 | |
| Dion James | 14 | 596 | 1989 | ||
| Juan Samuel | 14 | 606 | 1987 | ||
| Juan Samuel | 14 | 608 | 1985 | ||
| Bump Wills | 14 | 721 | 1983 | ||
| Pedro Garcia | 14 | 585 | 1983 | ||
| Tom Brookens | 14 | 556 | 1983 | ||
| Paul Molitor | 14 | 643 | 1982 | ||
| Pedro Garcia | 14 | 532 | 1982 | ||
| Lou Whitaker | 14 | 598 | 1981 | ||
| Lou Whitaker | 14 | 678 | 1980 | ||
| Pedro Garcia | 14 | 549 | 1976 | ||
| Ken Boswell | 14 | 619 | 1975 | ||
| Marty Martinez | 14 | 670 | 1973 | ||
| Gary Geiger | 14 | 543 | 1972 | ||
| Don Demeter | 14 | 547 | 1971 | ||
| Nelson Mathews | 14 | 571 | 1967 | ||
| Jim Lefebvre | 14 | 609 | 1966 | ||
| Ted Lepcio | 14 | 443 | 1965 | ||
| Jim Davenport | 14 | 404 | 1965 | ||
| Jim Davenport | 14 | 510 | 1964 | ||
| Lee Walls | 14 | 706 | 1962 | ||
| Don Zimmer | 14 | 557 | 1958 | ||
| Bobby Avila | 14 | 595 | 1957 | ||
| Roy Hartsfield | 14 | 674 | 1956 | ||
| Pee Wee Reese * | 14 | 740 | 1954 | ||
| Billy Cox | 14 | 675 | 1954 | ||
| Lou Stringer | 14 | 660 | 1952 | ||
| Billy Cox | 14 | 687 | 1950 | ||
| Pee Wee Reese * | 14 | 736 | 1948 | ||
| Grady Hatton | 14 | 515 | 1948 | ||
| Sherry Robertson | 14 | 499 | 1947 | ||
| Lou Stringer | 14 | 447 | 1947 | ||
| Hank Thompson | 14 | 304 | 1947 | ||
| Billy Johnson | 14 | 627 | 1944 | ||
| Jim Bucher | 14 | 549 | 1942 | ||
| Tony Lazzeri * | 14 | 639 | 1939 | ||
| 228. | Paul Runge | 13 | 601 | 1988 | |
| Terry Pendleton | 13 | 495 | 1988 | ||
| Greg Luzinski | 13 | 340 | 1987 | ||
| Bump Wills | 13 | 688 | 1985 | ||
| Pedro Garcia | 13 | 636 | 1984 | ||
| Rance Mulliniks | 13 | 602 | 1984 | ||
| Joel Youngblood | 13 | 391 | 1980 | ||
| Pedro Garcia | 13 | 551 | 1979 | ||
| Joe Morgan | 13 | 628 | 1978 | ||
| Lou Whitaker | 13 | 481 | 1978 | ||
| Davey Lopes | 13 | 586 | 1977 | ||
| Pedro Garcia | 13 | 505 | 1977 | ||
| Willie Horton | 13 | 503 | 1976 | ||
| Wayne Comer | 13 | 577 | 1971 | ||
| Felix Millan | 13 | 559 | 1971 | ||
| Jim Lefebvre | 13 | 641 | 1970 | ||
| Gene Stephens | 13 | 659 | 1965 | ||
| Willie Horton | 13 | 445 | 1965 | ||
| Bernie Allen | 13 | 483 | 1963 | ||
| Lee Walls | 13 | 576 | 1958 | ||
| Bobby Avila | 13 | 584 | 1956 | ||
| Bobby Avila | 13 | 676 | 1955 | ||
| Tommy Glaviano | 13 | 585 | 1955 | ||
| Sherry Robertson | 13 | 393 | 1955 | ||
| Pee Wee Reese * | 13 | 682 | 1953 | ||
| Pee Wee Reese * | 13 | 710 | 1952 | ||
| Johnny Lucadello | 13 | 601 | 1951 | ||
| Joe Gordon | 13 | 272 | 1947 | ||
| Jim Bucher | 13 | 634 | 1946 | ||
| Joe Gordon | 13 | 269 | 1946 | ||
| Alex Kampouris | 13 | 618 | 1942 | ||
| Tony Lazzeri * | 13 | 493 | 1940 | ||
| Stan Hack | 13 | 699 | 1939 | ||
| Stan Hack | 13 | 711 | 1938 | ||
| Billy Myers | 13 | 639 | 1938 | ||
| Alex Kampouris | 13 | 600 | 1937 | ||
| Alex Kampouris | 13 | 588 | 1935 | ||
| Max Bishop | 13 | 688 | 1930 | ||
| Tony Lazzeri * | 13 | 673 | 1930 | ||
| 267. | Lenn Sakata | 12 | 446 | 1990 | |
| Matt Williams | 12 | 311 | 1990 | ||
| Ryne Sandberg | 12 | 641 | 1988 | ||
| Luis Aguayo | 12 | 505 | 1986 | ||
| Bobby Grich | 12 | 600 | 1981 | ||
| Fernando Gonzalez | 12 | 548 | 1979 | ||
| Lee Lacy | 12 | 611 | 1977 | ||
| Jim Lefebvre | 12 | 558 | 1975 | ||
| Pedro Garcia | 12 | 536 | 1975 | ||
| Rod Carew | 12 | 631 | 1974 | ||
| Marty Martinez | 12 | 655 | 1972 | ||
| Gary Geiger | 12 | 591 | 1971 | ||
| Charley Smith | 12 | 592 | 1969 | ||
| Don Buddin | 12 | 580 | 1969 | ||
| Jim Lefebvre | 12 | 587 | 1968 | ||
| Joe Morgan | 12 | 640 | 1967 | ||
| Johnny Goryl | 12 | 420 | 1967 | ||
| Mike De La Hoz | 12 | 604 | 1964 | ||
| Tony Oliva | 12 | 429 | 1964 | ||
| Leo Burke | 12 | 535 | 1963 | ||
| Hank Thompson | 12 | 317 | 1962 | ||
| Hank Thompson | 12 | 477 | 1961 | ||
| Lee Walls | 12 | 668 | 1960 | ||
| Tommy Glaviano | 12 | 687 | 1959 | ||
| Gene Stephens | 12 | 591 | 1956 | ||
| Billy Goodman | 12 | 357 | 1953 | ||
| Johnny Lucadello | 12 | 458 | 1950 | ||
| Pee Wee Reese * | 12 | 700 | 1949 | ||
| Alex Kampouris | 12 | 425 | 1947 | ||
| Alex Kampouris | 12 | 584 | 1945 | ||
| Jim Bucher | 12 | 495 | 1943 | ||
| Joe Gordon | 12 | 441 | 1943 | ||
| Jim Bucher | 12 | 626 | 1940 | ||
| Leo Norris | 12 | 429 | 1940 |
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