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| Second Basemen Career Homeruns Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Homeruns | PA | Years | Single Season Leaderboard |
| 1. | Gil McDougald * | 418 | 8973 | 1951-1965 | |
| 2. | Greg Luzinski | 361 | 10636 | 1971-1988 | |
| 3. | Hank Thompson | 354 | 8521 | 1947-1962 | |
| 4. | Don Demeter | 339 | 7229 | 1958-1971 | |
| 5. | Willie Horton | 238 | 8507 | 1965-1980 | |
| 6. | Gary Geiger | 234 | 7277 | 1960-1973 | |
| 7. | Lou Whitaker | 225 | 7303 | 1978-1990 | |
| 8. | Joe Morgan | 221 | 11796 | 1963-1982 | |
| 9. | Tony Lazzeri * | 213 | 7117 | 1930-1941 | |
| 10. | Grady Hatton | 196 | 5328 | 1946-1953 | |
| 11. | Pee Wee Reese * | 190 | 10850 | 1940-1956 | |
| 12. | Paul Molitor | 175 | 7915 | 1978-1990 | |
| Alex Kampouris | 175 | 8618 | 1934-1949 | ||
| 14. | Nelson Mathews | 168 | 4788 | 1964-1974 | |
| Sherry Robertson | 168 | 5770 | 1942-1955 | ||
| 16. | Joe Gordon | 166 | 3989 | 1938-1950 | |
| 17. | Lee Walls | 165 | 8031 | 1955-1969 | |
| 18. | Johnny Goryl | 154 | 4973 | 1960-1970 | |
| 19. | Jorge Orta | 142 | 7336 | 1976-1988 | |
| 20. | Ryne Sandberg | 141 | 5379 | 1981-1990 | |
| 21. | Rod Carew | 136 | 9409 | 1967-1983 | |
| 22. | Bobby Grich | 133 | 7379 | 1973-1985 | |
| 23. | Jim Lefebvre | 130 | 6564 | 1966-1978 | |
| 24. | Stan Hack | 121 | 9770 | 1933-1947 | |
| 25. | Pedro Garcia | 116 | 5561 | 1975-1986 | |
| 26. | Ted Lepcio | 115 | 2707 | 1954-1968 | |
| 27. | Gene Stephens | 113 | 6242 | 1955-1969 | |
| Jim Bucher | 113 | 5654 | 1936-1949 | ||
| 29. | Billy Cox | 110 | 7479 | 1941-1957 | |
| 30. | Rance Mulliniks | 109 | 7767 | 1978-1990 | |
| 31. | Tommy Glaviano | 105 | 6901 | 1951-1962 | |
| 32. | Johnny Lucadello | 102 | 6957 | 1940-1954 | |
| 33. | Bump Wills | 101 | 7130 | 1977-1988 | |
| Charley Smith | 101 | 3908 | 1961-1972 | ||
| 35. | Lou Stringer | 100 | 6251 | 1941-1954 | |
| 36. | Don Buddin | 99 | 4566 | 1958-1971 | |
| 37. | Leo Cardenas | 94 | 6972 | 1961-1977 | |
| Bobby Avila | 94 | 4265 | 1949-1960 | ||
| 39. | Jim Davenport | 93 | 3359 | 1958-1968 | |
| 40. | Marty Martinez | 92 | 6264 | 1962-1978 | |
| 41. | Lee Lacy | 86 | 7483 | 1972-1986 | |
| 42. | Max Bishop | 84 | 4901 | 1930-1938 | |
| 43. | Juan Samuel | 83 | 4225 | 1983-1990 | |
| Mike De La Hoz | 83 | 6019 | 1962-1976 | ||
| 45. | Ken Boswell | 75 | 5015 | 1971-1981 | |
| Solly Hemus | 75 | 5849 | 1949-1960 | ||
| 47. | Paul Schaal | 74 | 6529 | 1965-1979 | |
| 48. | Joel Youngblood | 73 | 4993 | 1977-1986 | |
| 49. | Roy Hartsfield | 72 | 4471 | 1950-1958 | |
| 50. | Felix Millan | 71 | 5199 | 1968-1980 | |
| Billy Johnson | 71 | 5364 | 1943-1957 | ||
| 52. | Johnny Hodapp | 67 | 5384 | 1930-1941 | |
| 53. | Joe Caffie | 62 | 4441 | 1957-1969 | |
| 54. | Dutch Meyer | 61 | 5288 | 1941-1952 | |
| 55. | Bernie Allen | 60 | 4142 | 1962-1972 | |
| 56. | Chico Carrasquel | 59 | 6237 | 1951-1964 | |
| 57. | Cal Ripken Jr. | 56 | 2925 | 1981-1990 | |
| Tito Fuentes | 56 | 5415 | 1966-1981 | ||
| 59. | Jimmie Dykes | 55 | 1827 | 1930-1932 | |
| 60. | Eddie Stanky | 54 | 5930 | 1943-1953 | |
| 61. | Tim Teufel | 52 | 3207 | 1983-1990 | |
| Johnny Bero | 52 | 1948 | 1949-1958 | ||
| 63. | Lenn Sakata | 51 | 3345 | 1983-1990 | |
| Frank Bolling | 51 | 3545 | 1957-1968 | ||
| 65. | Don Blasingame | 50 | 7457 | 1956-1970 | |
| 66. | George Grantham | 49 | 3075 | 1930-1936 | |
| 67. | Dion James | 46 | 3016 | 1984-1990 | |
| Kevin Elster | 46 | 1527 | 1988-1990 | ||
| Tom Brookens | 46 | 2635 | 1980-1986 | ||
| Charlie Gehringer | 46 | 4091 | 1930-1939 | ||
| 71. | Kiko Garcia | 45 | 5644 | 1979-1990 | |
| Davey Lopes | 45 | 3628 | 1972-1978 | ||
| George Strickland | 45 | 4271 | 1954-1962 | ||
| Billy Myers | 45 | 4858 | 1935-1949 | ||
| 75. | Ted Sizemore | 44 | 5889 | 1970-1981 | |
| Granny Hamner | 44 | 1635 | 1951-1960 | ||
| 77. | Mickey Rivers | 43 | 4843 | 1973-1982 | |
| Pete Runnels | 43 | 7114 | 1952-1964 | ||
| 79. | Rodney Scott | 42 | 6432 | 1977-1990 | |
| Paul Runge | 42 | 3021 | 1985-1990 | ||
| Wayne Comer | 42 | 2089 | 1970-1978 | ||
| Bob Johnson | 42 | 2999 | 1960-1968 | ||
| Bernie James | 42 | 3697 | 1930-1941 | ||
| 84. | Randy Ready | 40 | 3950 | 1983-1990 | |
| 85. | Robby Thompson | 39 | 2905 | 1986-1990 | |
| Jim Gilliam | 39 | 6930 | 1953-1963 | ||
| Bama Rowell | 39 | 3696 | 1941-1953 | ||
| 88. | Tony Oliva | 38 | 1610 | 1964-1971 | |
| 89. | Rob Andrews | 37 | 4285 | 1976-1987 | |
| Tom Upton | 37 | 5226 | 1953-1964 | ||
| Bob Barrett | 37 | 2566 | 1930-1934 | ||
| 92. | Stu Martin | 36 | 3608 | 1937-1947 | |
| 93. | Billy Goodman | 35 | 1796 | 1950-1959 | |
| 94. | Bobby Knoop | 34 | 2807 | 1969-1974 | |
| Jerry Standaert | 34 | 3697 | 1930-1938 | ||
| 96. | Don Zimmer | 33 | 1451 | 1957-1962 | |
| Bobby Reeves | 33 | 4861 | 1930-1939 | ||
| 98. | Fernando Gonzalez | 32 | 1907 | 1975-1982 | |
| Stu Clarke | 32 | 2482 | 1930-1940 | ||
| 100. | Terry Pendleton | 31 | 2097 | 1985-1990 | |
| Chuck Schilling | 31 | 6580 | 1962-1974 | ||
| Stan Sperry | 31 | 2712 | 1939-1948 | ||
| 103. | Jack Perconte | 30 | 5399 | 1980-1990 | |
| Rudy Meoli | 30 | 3268 | 1977-1989 | ||
| Red Schoendienst | 30 | 3142 | 1947-1959 | ||
| Leo Norris | 30 | 1459 | 1937-1942 | ||
| Bill Cissell | 30 | 3704 | 1930-1941 | ||
| Irv Jeffries | 30 | 2207 | 1930-1941 | ||
| 109. | Rick Manning | 29 | 6261 | 1975-1988 | |
| Roy Smalley | 29 | 1748 | 1953-1963 | ||
| Mickey Witek | 29 | 2330 | 1940-1950 | ||
| Lonny Frey | 29 | 3718 | 1935-1946 | ||
| Hughie Critz | 29 | 4335 | 1930-1937 | ||
| 114. | Tom Herr | 28 | 6147 | 1981-1990 | |
| Taylor Duncan | 28 | 5305 | 1978-1989 | ||
| Eddie Mayo | 28 | 2004 | 1938-1943 | ||
| 117. | Sergio Ferrer | 27 | 2534 | 1977-1985 | |
| Nellie Fox | 27 | 1553 | 1953-1963 | ||
| Cecil Travis | 27 | 7099 | 1934-1948 | ||
| Fresco Thompson | 27 | 3284 | 1930-1937 | ||
| 121. | Jay Bell | 26 | 2121 | 1986-1990 | |
| Leo Burke | 26 | 1478 | 1962-1969 | ||
| 123. | Bill Doran | 25 | 2647 | 1983-1990 | |
| 124. | Matt Williams | 24 | 757 | 1988-1990 | |
| Ray Boone | 24 | 1026 | 1948-1956 | ||
| Mark Koenig | 24 | 5408 | 1930-1941 | ||
| Billy Rogell | 24 | 2515 | 1930-1939 | ||
| Doc Gautreau | 24 | 4782 | 1930-1938 | ||
| 129. | Tim Hulett | 23 | 1120 | 1983-1989 | |
| Bert Campaneris | 23 | 4375 | 1965-1975 | ||
| Mickey Haslin | 23 | 2584 | 1935-1947 | ||
| 132. | Rennie Stennett | 22 | 1888 | 1971-1983 | |
| Don Gutteridge | 22 | 1963 | 1937-1948 | ||
| Billy Herman | 22 | 7161 | 1932-1945 | ||
| Wally Kimmick | 22 | 2445 | 1930-1934 | ||
| 136. | Damaso Garcia | 21 | 3357 | 1980-1990 | |
| Dick Green | 21 | 1471 | 1967-1973 | ||
| 138. | Luis Aguayo | 20 | 957 | 1985-1988 | |
| Jerry Terrell | 20 | 4782 | 1973-1982 | ||
| Ron Theobald | 20 | 3734 | 1971-1978 | ||
| Dick Culler | 20 | 1678 | 1939-1949 | ||
| Greg Mulleavy | 20 | 2735 | 1933-1944 | ||
| 143. | Roberto Alomar | 19 | 1666 | 1988-1990 | |
| Mariano Duncan | 19 | 1471 | 1985-1990 | ||
| Terry Harmon | 19 | 4749 | 1970-1979 | ||
| Al Kozar | 19 | 3047 | 1949-1955 | ||
| Ed Montague | 19 | 2825 | 1931-1941 | ||
| Rogers Hornsby | 19 | 1274 | 1930-1931 | ||
| 149. | Derrel Thomas | 18 | 3085 | 1977-1983 | |
| Emil Verban | 18 | 2138 | 1944-1952 | ||
| 151. | Steve Sax | 17 | 2195 | 1984-1990 | |
| Barbaro Garbey | 17 | 1721 | 1985-1990 | ||
| Don Hoak | 17 | 738 | 1955-1962 | ||
| Rocky Bridges | 17 | 1579 | 1954-1961 | ||
| 155. | Jay Partridge | 16 | 1850 | 1930-1937 | |
| 156. | Nelson Liriano | 15 | 1143 | 1989-1990 | |
| Joe Demaestri | 15 | 1106 | 1956-1965 | ||
| Heinie Mueller | 15 | 1592 | 1940-1946 | ||
| Les Mallon | 15 | 1880 | 1931-1941 | ||
| 160. | Vance Law | 14 | 1099 | 1983-1987 | |
| Frank Baker | 14 | 2044 | 1975-1981 | ||
| 162. | Rob Ellis | 13 | 4143 | 1975-1986 | |
| Larry Bowa | 13 | 2030 | 1970-1980 | ||
| Marv Breeding | 13 | 2775 | 1960-1972 | ||
| Joe Chamberlain | 13 | 1000 | 1938-1945 | ||
| Jake Flowers | 13 | 2188 | 1930-1935 | ||
| 167. | Gregg Jefferies | 12 | 609 | 1989-1990 | |
| Andy High | 12 | 2700 | 1930-1936 | ||
| Carl Lind | 12 | 1377 | 1930-1936 | ||
| 170. | Jose Oquendo | 11 | 2963 | 1986-1990 | |
| Glenn Hubbard | 11 | 1215 | 1979-1982 | ||
| Luis Alcaraz | 11 | 352 | 1969-1971 | ||
| Jack Saltzgaver | 11 | 1200 | 1932-1938 | ||
| 174. | Julio Cruz | 10 | 1565 | 1981-1990 | |
| Jeff Treadway | 10 | 1394 | 1987-1990 | ||
| Mario Guerrero | 10 | 1448 | 1976-1985 | ||
| Jack Brohamer | 10 | 955 | 1975-1980 | ||
| Jerry Lumpe | 10 | 2846 | 1957-1967 | ||
| Billy Gardner | 10 | 1316 | 1955-1963 | ||
| Willy Miranda | 10 | 661 | 1957-1958 | ||
| Al Glossop | 10 | 417 | 1945-1949 | ||
| Babe Ellison | 10 | 1237 | 1930-1932 | ||
| 183. | Bip Roberts | 9 | 2012 | 1987-1990 | |
| Tim Johnson | 9 | 2100 | 1974-1982 | ||
| Jim Pyburn | 9 | 1025 | 1957-1967 | ||
| Freddy Spurgeon | 9 | 2733 | 1930-1937 | ||
| 187. | Ozzie Guillen | 8 | 2529 | 1985-1990 | |
| Johnny Temple | 8 | 2025 | 1952-1958 | ||
| Johnny Lipon | 8 | 1142 | 1955-1957 | ||
| Jimmy Jordan | 8 | 1641 | 1935-1943 | ||
| Frank Doljack | 8 | 797 | 1930-1939 | ||
| Bernie Friberg | 8 | 1714 | 1930-1934 | ||
| Otis Brannan | 8 | 301 | 1930-1931 | ||
| 194. | Keith Miller | 7 | 863 | 1988-1990 | |
| Larvell Blanks | 7 | 1292 | 1973-1981 | ||
| Dan Monzon | 7 | 1839 | 1974-1979 | ||
| Owen Friend | 7 | 560 | 1950-1954 | ||
| Babe Barna | 7 | 639 | 1941-1951 | ||
| Lew Malone | 7 | 1016 | 1930-1932 | ||
| Cotton Tierney | 7 | 781 | 1930-1931 | ||
| 201. | Spook Jacobs | 6 | 722 | 1954-1960 | |
| Marty Marion | 6 | 1989 | 1941-1951 | ||
| George Hausmann | 6 | 749 | 1946-1951 | ||
| Riggs Stephenson | 6 | 2104 | 1930-1936 | ||
| Freddie Maguire | 6 | 883 | 1930-1932 | ||
| Red Rollings | 6 | 683 | 1930-1931 | ||
| 207. | Jose Lind | 5 | 353 | 1988-1990 | |
| Geronimo Pena | 5 | 138 | 1990-1990 | ||
| Mike Champion | 5 | 1338 | 1981-1988 | ||
| Buddy Biancalana | 5 | 555 | 1983-1987 | ||
| Bobby Valentine | 5 | 1767 | 1975-1985 | ||
| Bob Sheldon | 5 | 897 | 1978-1984 | ||
| Rich Severson | 5 | 1455 | 1970-1976 | ||
| Charlie English | 5 | 1233 | 1932-1941 | ||
| Jackie Hayes | 5 | 286 | 1931-1937 | ||
| Bill Regan | 5 | 1137 | 1930-1931 | ||
| 217. | Duane Kuiper | 4 | 1526 | 1978-1984 | |
| Julio Gonzalez | 4 | 1181 | 1978-1981 | ||
| Von Joshua | 4 | 329 | 1971-1981 | ||
| Horace Clarke | 4 | 1058 | 1965-1978 | ||
| Ernie Bowman | 4 | 419 | 1965-1966 | ||
| Burgess Whitehead | 4 | 599 | 1935-1943 | ||
| Marv Olson | 4 | 2818 | 1933-1942 | ||
| Bill Wambsganss | 4 | 512 | 1930-1931 | ||
| 225. | Marty Barrett | 3 | 798 | 1984-1990 | |
| Delino Deshields | 3 | 359 | 1990-1990 | ||
| Pat Rockett | 3 | 1228 | 1980-1989 | ||
| Jim Mason | 3 | 567 | 1980-1981 | ||
| Mark Belanger | 3 | 447 | 1977-1980 | ||
| Rob Wilfong | 3 | 245 | 1977-1978 | ||
| Casey Wise | 3 | 430 | 1960-1961 | ||
| Eddie Basinski | 3 | 218 | 1946-1957 | ||
| Jack Merson | 3 | 213 | 1953-1953 | ||
| Nanny Fernandez | 3 | 685 | 1942-1952 | ||
| Mike Herrera | 3 | 223 | 1930-1932 | ||
| 236. | Lance Blankenship | 2 | 314 | 1990-1990 | |
| Mike Gates | 2 | 1084 | 1981-1988 | ||
| Mario Ramirez | 2 | 142 | 1982-1985 | ||
| Pepe Frias | 2 | 1031 | 1974-1983 | ||
| John Knox | 2 | 573 | 1974-1982 | ||
| Jerry Manuel | 2 | 272 | 1980-1981 | ||
| Mel Roach | 2 | 464 | 1964-1967 | ||
| Charlie Gilbert | 2 | 606 | 1947-1952 | ||
| Crash Davis | 2 | 363 | 1948-1949 | ||
| Johnny Berardino | 2 | 352 | 1946-1947 | ||
| Jimmie Reese | 2 | 221 | 1930-1931 | ||
| Sam Bohne | 2 | 124 | 1930-1931 | ||
| 248. | Wallace Johnson | 1 | 769 | 1983-1990 | |
| Tommy Hinzo | 1 | 13 | 1988-1988 | ||
| Eddie Miller | 1 | 254 | 1982-1985 | ||
| Steve Staggs | 1 | 375 | 1979-1983 | ||
| Bill Russell | 1 | 330 | 1979-1980 | ||
| Billy Parker | 1 | 225 | 1978-1978 | ||
| Bill Stein | 1 | 80 | 1976-1976 | ||
| Hal Lanier | 1 | 285 | 1967-1974 | ||
| Tom Ragland | 1 | 397 | 1971-1973 | ||
| Winston Llenas | 1 | 367 | 1972-1973 | ||
| Ossie Chavarria | 1 | 375 | 1968-1972 | ||
| Luis Alvarado | 1 | 238 | 1971-1971 | ||
| Chuck Hiller | 1 | 87 | 1962-1966 | ||
| Gene Verble | 1 | 153 | 1960-1964 | ||
| Johnny O'Brien | 1 | 65 | 1963-1963 | ||
| Jack Cusick | 1 | 233 | 1961-1961 | ||
| Bill Sommers | 1 | 375 | 1950-1952 | ||
| Jack Conway | 1 | 131 | 1951-1952 | ||
| Ben Geraghty | 1 | 344 | 1941-1943 | ||
| Del Young | 1 | 226 | 1939-1942 | ||
| Billy Jurges | 1 | 915 | 1931-1940 | ||
| Joe Gedeon | 1 | 229 | 1930-1931 | ||
| Ski Melillo | 1 | 97 | 1930-1930 |
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