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| Thursday, November 22nd , 2001 |
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| SP Tyler Chatwood becomes a free-agent. |
| RP Tim Belcher becomes a free-agent. |
| SP Mike Flanagan becomes a free-agent. |
| SP Brandon Claussen becomes a free-agent. |
| SP Chuck Estrada becomes a free-agent. |
| SP MacKenzie Gore becomes a free-agent. |
| SP John Dettmer becomes a free-agent. |
| RP Collin Balester becomes a free-agent. |
| SP Marco Estrada becomes a free-agent. |
| Sunday, September 30th , 2001 |
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| SP Dick Estelle retired from professional baseball. |
| Monday, April 2nd , 2001 |
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| Received RP Jeff Brigham from Major League Arizona. |
| Received RP Collin Balester from Major League Arizona. |
| Received SP Rick Rodriguez from Major League Arizona. |
| Received RP Juan Alvarez from Major League Arizona. |
| Received RP Erik Bennett from Major League Arizona. |
| Received RP Joe Bisenius from Major League Arizona. |
| Received RP Cedrick Bowers from Major League Arizona. |
| Received RP Jim Brenneman from Major League Arizona. |
| Received C Humberto Quintero from Major League Arizona. |
| Received C Jim Spotts from Major League Arizona. |
| Received 2B Scat Metha from Major League Arizona. |
| Received 3B Greg Jelks from Major League Arizona. |
| Received LF Weston Wilson from Major League Arizona. |
| Received LF Dick Smith from Major League Arizona. |
| Received LF Carl Sumner from Major League Arizona. |
| Received C Doug Lindsey from Major League Arizona. |
| Received C John Hairston from Major League Arizona. |
| Thursday, March 1st , 2001 |
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| Promoted RP Collin Balester to Major League Arizona. |
| Wednesday, February 28th , 2001 |
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| Promoted SP Tim Belcher to Major League Arizona. |
| Promoted RP Juan Alvarez to Major League Arizona. |
| Wednesday, January 31st , 2001 |
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| Drafted SP Brett Tomko in the 2001 first-year player draft (Round 1, Pick 16, 16th overall pick). |
| Drafted 1B Jim Marshall in the 2001 first-year player draft (Round 2, Pick 16, 36th overall pick). |
| Drafted LF Weston Wilson in the 2001 first-year player draft (Round 5, Pick 16, 96th overall pick). |
| Drafted LF Carl Sumner in the 2001 first-year player draft (Round 6, Pick 16, 116th overall pick). |
