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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Hal Newhouser | 273 | 1985 | |
| 2 | Mark Langston* | 263 | 1986 | |
| 3 | Jose Rijo# | 262 | 1994 | |
| 4 | Tom Gordon# | 257 | 1995 | |
| 5 | Dizzy Dean# | 247 | 1996 | |
| 6 | Hal Newhouser | 244 | 1989 | |
| 7 | Mark Langston* | 242 | 1984 | |
| 8 | Don Drysdale# | 239 | 2001 | |
| 9 | Andy Benes# | 238 | 2000 | |
| 10 | Kenta Maeda | 237 | 1986 | |
| 11 | Hal Newhouser | 236 | 1988 | |
| 11 | Mark Langston* | 236 | 1987 | |
| 13 | John Montefusco | 232 | 1987 | |
| 14 | John Patterson | 231 | 1984 | |
| 14 | Les Tietje | 231 | 1986 | |
| 14 | Tom Gordon# | 231 | 1994 | |
| 17 | Ian Snell | 229 | 1987 | |
| 18 | Carl Hubbell# | 228 | 1996 | |
| 19 | Jose Rijo# | 227 | 1995 | |
| 20 | Todd Stottlemyre | 226 | 1986 | |
| 20 | Dave Boswell# | 226 | 2000 | |
| 22 | Les Tietje | 225 | 1984 | |
| 22 | Jeff Sellers | 225 | 1987 | |
| 24 | John Montefusco | 224 | 1986 | |
| 24 | Blake Snell# | 224 | 1996 | |
| 24 | Vern Olsen# | 224 | 1995 | |
| 27 | Carl Hubbell# | 223 | 1998 | |
| 27 | Barry Zito | 223 | 1986 | |
| 27 | Don Drysdale# | 223 | 2000 | |
| 30 | Kenta Maeda | 222 | 1987 | |
| 30 | Dizzy Dean# | 222 | 1995 | |
| 32 | Les Tietje | 221 | 1985 | |
| 32 | Aaron Nola | 221 | 1989 | |
| 34 | Carl Hubbell# | 220 | 2000 | |
| 34 | Carl Hubbell# | 220 | 1997 | |
| 34 | Mark Langston* | 220 | 1985 | |
| 37 | John Patterson | 219 | 1983 | |
| 37 | Dizzy Dean# | 219 | 1994 | |
| 39 | Sam McDowell | 218 | 1991 | |
| 40 | Todd Stottlemyre | 216 | 1987 | |
| 40 | Dave Boswell# | 216 | 1998 | |
| 42 | Bobby Shantz | 215 | 1983 | |
| 42 | Bobby Shantz | 215 | 1984 | |
| 42 | John Patterson | 215 | 1988 | |
| 42 | Frank Baumann# | 215 | 2001 | |
| 46 | Joe Krakauskas | 214 | 1984 | |
| 46 | Daisuke Matsuzaka | 214 | 1987 | |
| 46 | Ike Delock | 214 | 1990 | |
| 49 | Barry Zito | 213 | 1987 | |
| 49 | Sterling Hitchcock | 213 | 1986 | |
| 51 | Blake Snell# | 212 | 1995 | |
| 52 | Jeff Sellers | 211 | 1988 | |
| 53 | Mickey Harris# | 210 | 1986 | |
| 53 | Jose Rijo# | 210 | 1996 | |
| 53 | Blake Snell# | 210 | 1994 | |
| 56 | Dean Chance# | 209 | 1995 | |
| 56 | John Candelaria# | 209 | 1984 | |
| 58 | Blake Snell# | 208 | 1990 | |
| 58 | Ike Delock | 208 | 1989 | |
| 58 | Dave Boswell# | 208 | 1995 | |
| 58 | Jeff Sellers | 208 | 1986 | |
| 62 | Blake Snell# | 207 | 1997 | |
| 62 | Sam McDowell | 207 | 1992 | |
| 62 | John Candelaria# | 207 | 1986 | |
| 62 | Jakob Junis | 207 | 1987 | |
| 66 | Scott Sanderson | 206 | 1988 | |
| 66 | Bobby Shantz | 206 | 1987 | |
| 68 | Jim Golden# | 205 | 1998 | |
| 69 | Tom Gordon# | 204 | 1993 | |
| 70 | Ellis Kinder | 203 | 1985 | |
| 70 | Phil Ortega# | 203 | 2001 | |
| 70 | Blake Snell# | 203 | 1999 | |
| 70 | Sean Manaea | 203 | 1988 | |
| 74 | John Patterson | 202 | 1989 | |
| 74 | Hal Newhouser | 202 | 1986 | |
| 74 | Kevin Appier# | 202 | 2001 | |
| 74 | Mark Langston* | 202 | 1990 | |
| 78 | Sam Jones# | 200 | 1999 | |
| 78 | Jason Hammel# | 200 | 1991 | |
| 78 | Dave Boswell# | 200 | 1996 | |
| 81 | Jeff Samardzija | 199 | 1985 | |
| 81 | Ken Brett# | 199 | 2001 | |
| 81 | Ben Sheets | 199 | 1990 | |
| 81 | Mark Langston* | 199 | 1988 | |
| 85 | Carl Hubbell# | 198 | 1995 | |
| 85 | Dave Boswell# | 198 | 1999 | |
| 85 | Blake Snell# | 198 | 1989 | |
| 85 | Johnny Klippstein# | 198 | 1996 | |
| 85 | Mickey Lolich# | 198 | 1991 | |
| 85 | Sam McDowell | 198 | 1990 | |
| 91 | Carl Hubbell# | 197 | 1999 | |
| 91 | Mickey Lolich# | 197 | 1994 | |
| 91 | Oral Hildebrand# | 197 | 2001 | |
| 91 | Carl Hubbell# | 197 | 2001 | |
| 91 | Art Ceccarelli | 197 | 1986 | |
| 96 | Foster Edwards# | 196 | 1988 | |
| 96 | Blake Stein | 196 | 1982 | |
| 96 | Jack Fisher# | 196 | 2000 | |
| 96 | John Candelaria# | 196 | 1981 | |
| 96 | John Patterson | 196 | 1987 |
