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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | John Candelaria# | 4916.0 | 1980-2001 | |
| 2 | Mark Buehrle# | 4731.0 | 1980-2001 | |
| 3 | Jon Matlack | 3837.0 | 1981-1999 | |
| 4 | Bob Friend | 3821.0 | 1980-1998 | |
| 5 | Jeff Sellers | 3621.0 | 1980-1998 | |
| 6 | Bob Anderson | 3522.0 | 1980-1997 | |
| 7 | Mark Langston* | 3454.0 | 1980-1994 | |
| 8 | John Patterson | 3401.0 | 1981-1997 | |
| 9 | Warren Spahn | 3314.0 | 1980-1995 | |
| 10 | Esteban Loaiza# | 3242.0 | 1988-2001 | |
| 11 | Barry Zito | 3145.0 | 1980-1994 | |
| 12 | Chris Bosio | 2950.0 | 1980-1998 | |
| 13 | Roy Oswalt# | 2940.0 | 1988-2001 | |
| 14 | Sonny Siebert | 2885.0 | 1982-1999 | |
| 15 | Bill Lee | 2833.0 | 1983-1999 | |
| 16 | Bobby Shantz | 2826.0 | 1981-1997 | |
| 17 | Don Kaiser# | 2815.0 | 1984-2000 | |
| 18 | Walker Buehler# | 2782.0 | 1988-2000 | |
| 19 | Robbie Ray | 2771.0 | 1980-1992 | |
| 20 | Red Witt# | 2767.0 | 1982-2001 | |
| 21 | Gaylord Perry | 2751.0 | 1980-1995 | |
| 22 | Craig Swan | 2750.0 | 1980-1993 | |
| 23 | Jerad Eickhoff | 2742.0 | 1981-1997 | |
| 24 | Blake Snell# | 2704.0 | 1988-2001 | |
| 25 | Phil Niekro | 2695.0 | 1983-1998 | |
| 26 | Ben Sheets | 2690.0 | 1983-2001 | |
| 27 | Hal Newhouser | 2685.0 | 1985-1998 | |
| 28 | Bill Bevens | 2637.0 | 1982-1993 | |
| 29 | Ian Snell | 2623.0 | 1980-1992 | |
| 30 | Jim Merritt | 2597.0 | 1980-1994 | |
| 31 | Kenta Maeda | 2584.0 | 1982-1994 | |
| 32 | Kyle Freeland# | 2581.0 | 1988-2000 | |
| 33 | Tim Belcher# | 2499.0 | 1987-2001 | |
| 34 | Jason Hammel# | 2483.0 | 1989-2001 | |
| 35 | Omar Olivares | 2469.0 | 1980-1993 | |
| 36 | Foster Edwards# | 2468.0 | 1983-2001 | |
| 37 | Sean Manaea | 2451.0 | 1987-2000 | |
| 38 | Dustin Hermanson# | 2376.0 | 1987-2001 | |
| 39 | Mickey Harris# | 2374.0 | 1986-1999 | |
| 40 | Ray Bare# | 2364.0 | 1987-2001 | |
| 41 | Len Barker | 2356.0 | 1980-1992 | |
| 41 | Red Embree | 2356.0 | 1981-1994 | |
| 43 | Don Sutton# | 2329.0 | 1987-1998 | |
| 44 | La Marr Hoyt# | 2291.0 | 1985-2000 | |
| 45 | Sam McDowell | 2265.0 | 1986-1999 | |
| 46 | Kip Wells# | 2256.0 | 1986-2000 | |
| 47 | John Miller# | 2252.0 | 1986-2000 | |
| 48 | Todd Stottlemyre | 2235.0 | 1983-1995 | |
| 49 | Carl Hubbell# | 2229.0 | 1992-2001 | |
| 50 | John Montefusco | 2201.0 | 1986-1997 | |
| 51 | Joe Coleman | 2192.0 | 1981-1994 | |
| 52 | Urbano Lugo | 2186.0 | 1980-1993 | |
| 53 | Jakob Junis | 2170.0 | 1984-1997 | |
| 54 | Jim Rooker | 2153.0 | 1980-1990 | |
| 55 | Mickey Lolich# | 2144.0 | 1988-2001 | |
| 56 | Jon Garland# | 2141.0 | 1987-2000 | |
| 57 | Sterling Hitchcock | 2109.0 | 1980-1990 | |
| 58 | Luke Hochevar | 2088.0 | 1980-1996 | |
| 59 | Jimmy Key# | 2075.0 | 1988-1997 | |
| 60 | Jin-ho Cho | 2050.0 | 1980-1991 | |
| 61 | Barry Moore | 2037.0 | 1980-1992 | |
| 62 | Chad Gaudin | 2018.0 | 1981-1993 | |
| 63 | Hiroki Kuroda# | 2012.0 | 1993-2001 | |
| 64 | Steven Matz# | 2007.0 | 1989-2000 | |
| 65 | Daisuke Matsuzaka | 2006.0 | 1986-1997 | |
| 66 | Carl Fischer | 1988.0 | 1980-1990 | |
| 67 | Gary Bell# | 1975.0 | 1990-2001 | |
| 68 | Bob Moose | 1974.0 | 1980-1989 | |
| 69 | Chris Holt# | 1959.0 | 1993-2001 | |
| 70 | Chris Bassitt | 1952.0 | 1986-1996 | |
| 71 | Luke Weaver# | 1943.0 | 1992-2001 | |
| 72 | Brayan Bello# | 1935.0 | 1987-2001 | |
| 73 | Odalis Perez | 1913.0 | 1985-1995 | |
| 74 | Mike Nagy# | 1912.0 | 1992-2001 | |
| 75 | Albie Lopez | 1909.0 | 1984-2000 | |
| 76 | Wayne Schurr# | 1904.0 | 1986-1999 | |
| 77 | Blake Stein | 1901.0 | 1980-1988 | |
| 78 | Aaron Nola | 1900.0 | 1989-1997 | |
| 79 | Dean Chance# | 1899.0 | 1993-2001 | |
| 80 | Homer Bailey# | 1895.0 | 1991-2001 | |
| 81 | Red Munger# | 1890.0 | 1993-2001 | |
| 82 | Hub Pruett | 1887.0 | 1980-1994 | |
| 83 | Earl Francis# | 1877.0 | 1991-2001 | |
| 84 | Teddy Higuera# | 1861.0 | 1992-2001 | |
| 85 | Doug Rau# | 1858.0 | 1992-2001 | |
| 86 | Jim Willis | 1854.0 | 1980-1990 | |
| 87 | Lary Sorensen | 1851.0 | 1980-1995 | |
| 88 | Tom Gordon# | 1849.0 | 1993-2001 | |
| 89 | Rollie Sheldon | 1812.0 | 1984-1995 | |
| 90 | Jim Golden# | 1805.0 | 1990-2001 | |
| 91 | Phil Marchildon | 1799.0 | 1980-1988 | |
| 92 | Art Ceccarelli | 1772.0 | 1980-1989 | |
| 92 | Omar Daal | 1772.0 | 1980-1990 | |
| 94 | Jose Rijo# | 1770.0 | 1993-2001 | |
| 95 | Dizzy Dean# | 1769.0 | 1993-2000 | |
| 96 | Ismael Valdez | 1756.0 | 1980-1990 | |
| 97 | Dillon Gee# | 1752.0 | 1993-2001 | |
| 98 | Bruce Howard# | 1733.0 | 1990-2001 | |
| 99 | Aaron Small# | 1725.0 | 1992-2001 | |
| 100 | Jack Fisher# | 1713.0 | 1994-2001 |
