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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Sam Jones# | 378 | 1992 | |
| 2 | Britt Burns | 360 | 1992 | |
| 3 | Thornton Lee# | 357 | 1994 | |
| 4 | Les Tietje | 350 | 1990 | |
| 5 | Dillon Gee# | 338 | 1992 | |
| 6 | Bill Butler | 337 | 1991 | |
| 7 | Jose Rijo# | 336 | 1992 | |
| 8 | Bob Moose | 332 | 1990 | |
| 8 | Bob Harris | 332 | 1992 | |
| 10 | Bob Moose | 319 | 1991 | |
| 11 | Ismael Valdez | 316 | 1994 | |
| 11 | Les Cain | 316 | 1990 | |
| 13 | Ben Sheets# | 315 | 1983 | |
| 14 | Jimmy Key# | 313 | 1998 | |
| 15 | Vern Kennedy | 312 | 1989 | |
| 15 | Thornton Lee# | 312 | 1995 | |
| 17 | Jim Maloney# | 308 | 1986 | |
| 18 | Vern Kennedy | 307 | 1988 | |
| 19 | Vern Kennedy | 305 | 1984 | |
| 20 | Thornton Lee# | 304 | 1996 | |
| 21 | Ken Chase# | 303 | 1996 | |
| 22 | Todd Stottlemyre | 299 | 1997 | |
| 23 | Jim Maloney# | 298 | 1989 | |
| 24 | Bill Lee | 295 | 1983 | |
| 25 | Rollie Sheldon | 294 | 1996 | |
| 25 | Chuck Dobson | 294 | 1992 | |
| 25 | Jeff Samardzija# | 294 | 1984 | |
| 28 | Shawn Estes | 293 | 1987 | |
| 29 | Shawn Estes | 292 | 1989 | |
| 29 | Les Tietje | 292 | 1991 | |
| 29 | Scott McGregor | 292 | 1994 | |
| 29 | Ben Sheets# | 292 | 1982 | |
| 33 | Fred Baczewski# | 291 | 1995 | |
| 33 | Brian Kingman | 291 | 1992 | |
| 35 | Jakob Junis | 289 | 1996 | |
| 35 | Wayne Simpson | 289 | 1991 | |
| 35 | Ted Gray | 289 | 1984 | |
| 38 | Thornton Lee# | 288 | 1997 | |
| 39 | Jim Hughes# | 287 | 1995 | |
| 40 | Jim Maloney# | 285 | 1991 | |
| 41 | Mike Witt | 284 | 1994 | |
| 41 | Thornton Lee# | 284 | 1999 | |
| 41 | Joey Jay# | 284 | 1996 | |
| 41 | MacKenzie Gore# | 284 | 1993 | |
| 45 | Paul Moskau | 283 | 1994 | |
| 45 | Charlie Wagner# | 283 | 1998 | |
| 47 | Len Barker | 282 | 1994 | |
| 48 | Jim Maloney# | 281 | 1987 | |
| 48 | Hector Noesi# | 281 | 1994 | |
| 50 | Bob Knepper | 280 | 1992 | |
| 50 | Mark Lemongello | 280 | 1996 | |
| 50 | Shawn Chacon# | 280 | 1994 | |
| 53 | Joe Coleman | 279 | 1995 | |
| 54 | Charlie Wagner# | 278 | 1999 | |
| 54 | Clyde King# | 278 | 1997 | |
| 56 | Ike Delock | 277 | 1994 | |
| 56 | Victor Santos | 277 | 1992 | |
| 58 | Marv Breuer# | 276 | 1996 | |
| 58 | Wayne Simpson | 276 | 1992 | |
| 60 | Chris Bassitt | 275 | 1994 | |
| 60 | Len Barker | 275 | 1995 | |
| 60 | Albie Lopez | 275 | 1988 | |
| 60 | Mickey Lolich# | 275 | 1999 | |
| 64 | Todd Stottlemyre | 274 | 1983 | |
| 65 | Ken Chase# | 273 | 1999 | |
| 66 | Jim Hughes# | 272 | 1997 | |
| 66 | Reese Olson | 272 | 1992 | |
| 68 | Chris Bassitt | 271 | 1995 | |
| 68 | Mike LaCoss | 271 | 1997 | |
| 68 | Francisco Barrios | 271 | 1992 | |
| 71 | Charlie Wagner# | 270 | 1997 | |
| 71 | Vern Kennedy | 270 | 1983 | |
| 71 | Bill Butler | 270 | 1992 | |
| 74 | Todd Stottlemyre | 269 | 1998 | |
| 74 | Calvin Maduro# | 269 | 1998 | |
| 76 | Rufe Gentry# | 268 | 1999 | |
| 76 | Boom-Boom Beck# | 268 | 1998 | |
| 76 | John Montefusco | 268 | 1998 | |
| 76 | Ted Gray | 268 | 1993 | |
| 80 | Chuck Dobson | 267 | 1988 | |
| 80 | Rollie Sheldon | 267 | 1997 | |
| 82 | Homer Bailey# | 266 | 1990 | |
| 83 | Ricky Romero# | 265 | 1997 | |
| 83 | Ismael Valdez | 265 | 1991 | |
| 83 | Jeff Suppan# | 265 | 1993 | |
| 86 | Bill Lee | 264 | 1995 | |
| 87 | Kevin Ritz# | 263 | 1996 | |
| 88 | Tyler Chatwood# | 262 | 1996 | |
| 88 | Shawn Estes | 262 | 1988 | |
| 90 | Earl Wilson | 261 | 1989 | |
| 90 | Jesse Jefferson# | 261 | 1997 | |
| 90 | Lefty Stewart# | 261 | 1997 | |
| 90 | Hank Aguirre | 261 | 1989 | |
| 90 | Antonio Osuna | 261 | 1991 | |
| 90 | Tyler Anderson | 261 | 1988 | |
| 96 | Tim Wakefield# | 260 | 1998 | |
| 96 | Dave LaPoint | 260 | 1992 | |
| 98 | Francisco Barrios | 259 | 1989 | |
| 98 | Buck Marrow# | 259 | 1994 | |
| 98 | Bill Butler | 259 | 1990 |
