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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Bob Friend | 308.0 | 1984 | |
| 2 | Gaylord Perry | 304.0 | 1982 | |
| 3 | Johnny Antonelli | 301.0 | 1981 | |
| 4 | Jon Matlack | 300.0 | 1981 | |
| 5 | Chris Bassitt | 299.0 | 1987 | |
| 6 | Mark Langston* | 293.0 | 1984 | |
| 7 | Mark Langston* | 291.0 | 1987 | |
| 8 | Jakob Junis | 289.0 | 1987 | |
| 9 | Barry Zito | 288.0 | 1986 | |
| 10 | Jon Matlack | 285.0 | 1982 | |
| 10 | Sean Manaea# | 285.0 | 1989 | |
| 12 | Barry Zito | 284.0 | 1987 | |
| 12 | Mark Langston* | 284.0 | 1986 | |
| 14 | John Candelaria# | 283.0 | 1981 | |
| 14 | Sean Manaea# | 283.0 | 1988 | |
| 14 | Hal Newhouser | 283.0 | 1985 | |
| 17 | Esteban Loaiza# | 282.0 | 1992 | |
| 17 | Bob Friend | 282.0 | 1990 | |
| 17 | Kenta Maeda | 282.0 | 1987 | |
| 20 | Carl Hubbell# | 281.0 | 1998 | |
| 21 | John Candelaria# | 280.0 | 1984 | |
| 21 | Odalis Perez | 280.0 | 1988 | |
| 21 | John Montefusco | 280.0 | 1987 | |
| 21 | Ian Snell | 280.0 | 1981 | |
| 25 | John Patterson | 279.0 | 1984 | |
| 26 | Ken Johnson | 278.0 | 1982 | |
| 27 | Len Barker | 276.0 | 1982 | |
| 27 | Les Tietje | 276.0 | 1985 | |
| 27 | Bill Bevens | 276.0 | 1990 | |
| 30 | Les Tietje | 275.0 | 1984 | |
| 30 | Les Tietje | 275.0 | 1986 | |
| 32 | John Patterson | 273.0 | 1985 | |
| 32 | Kenta Maeda | 273.0 | 1986 | |
| 32 | John Candelaria# | 273.0 | 1985 | |
| 32 | Lary Sorensen | 273.0 | 1984 | |
| 32 | Ben Sheets# | 273.0 | 1990 | |
| 32 | Jason Hammel# | 273.0 | 1990 | |
| 32 | Mark Langston* | 273.0 | 1988 | |
| 32 | Dizzy Dean# | 273.0 | 1996 | |
| 40 | John Candelaria# | 272.0 | 1982 | |
| 40 | Esteban Loaiza# | 272.0 | 1990 | |
| 42 | John Patterson | 271.0 | 1983 | |
| 42 | Barry Zito | 271.0 | 1985 | |
| 42 | Jose Rijo# | 271.0 | 1994 | |
| 45 | Tyler Anderson | 270.0 | 1984 | |
| 45 | Bill Bevens | 270.0 | 1985 | |
| 45 | Johnny Antonelli | 270.0 | 1980 | |
| 48 | Dizzy Dean# | 269.0 | 1994 | |
| 49 | Mike Witt | 268.0 | 1992 | |
| 49 | Kenta Maeda | 268.0 | 1983 | |
| 49 | Mark Langston* | 268.0 | 1985 | |
| 52 | Sterling Hitchcock | 267.0 | 1983 | |
| 52 | Jeff Samardzija# | 267.0 | 1985 | |
| 52 | Atley Donald | 267.0 | 1989 | |
| 52 | Carl Hubbell# | 267.0 | 1996 | |
| 52 | Mike Flanagan# | 267.0 | 1992 | |
| 52 | Carl Hubbell# | 267.0 | 1997 | |
| 52 | Phil Marchildon | 267.0 | 1985 | |
| 52 | John Montefusco | 267.0 | 1989 | |
| 60 | Craig Swan | 266.0 | 1986 | |
| 60 | Jon Matlack | 266.0 | 1985 | |
| 60 | Bob Friend | 266.0 | 1987 | |
| 63 | Chris Bosio | 265.0 | 1990 | |
| 63 | Ike Delock | 265.0 | 1990 | |
| 63 | Sean Manaea# | 265.0 | 1990 | |
| 66 | Esteban Loaiza# | 264.0 | 1994 | |
| 66 | Gaylord Perry | 264.0 | 1990 | |
| 66 | Blake Stein | 264.0 | 1982 | |
| 66 | Barry Zito | 264.0 | 1988 | |
| 66 | Phil Marchildon | 264.0 | 1983 | |
| 66 | Kenta Maeda | 264.0 | 1984 | |
| 72 | Jon Matlack | 263.0 | 1991 | |
| 72 | Hal Newhouser | 263.0 | 1989 | |
| 72 | Foster Edwards# | 263.0 | 1988 | |
| 72 | Pat Combs# | 263.0 | 1992 | |
| 72 | Jon Matlack | 263.0 | 1990 | |
| 77 | Chris Bassitt | 262.0 | 1988 | |
| 77 | Hiroki Kuroda# | 262.0 | 1993 | |
| 77 | Jerad Eickhoff | 262.0 | 1988 | |
| 77 | Esteban Loaiza# | 262.0 | 1991 | |
| 77 | Jon Matlack | 262.0 | 1984 | |
| 77 | Dave Roberts# | 262.0 | 1999 | |
| 77 | Aaron Nola | 262.0 | 1989 | |
| 84 | Bob Friend | 261.0 | 1992 | |
| 84 | Joe Coleman | 261.0 | 1989 | |
| 84 | Jeff Sellers | 261.0 | 1988 | |
| 84 | Jerad Eickhoff | 261.0 | 1984 | |
| 84 | Esteban Loaiza# | 261.0 | 1989 | |
| 84 | Hal Newhouser | 261.0 | 1988 | |
| 84 | John Patterson | 261.0 | 1988 | |
| 84 | Kenta Maeda | 261.0 | 1982 | |
| 84 | Barry Zito | 261.0 | 1983 | |
| 84 | Ray Bare# | 261.0 | 1992 | |
| 84 | Bob Moose | 261.0 | 1981 | |
| 95 | Jerad Eickhoff | 260.0 | 1983 | |
| 95 | Barry Moore | 260.0 | 1988 | |
| 95 | Bill Bevens | 260.0 | 1984 | |
| 95 | Chris Bassitt | 260.0 | 1990 | |
| 95 | Kenta Maeda | 260.0 | 1988 | |
| 100 | John Montefusco | 259.0 | 1990 |
