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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Mark Buehrle# | 305 | 1980-2000 | |
| 2 | John Candelaria# | 274 | 1980-2000 | |
| 3 | Mark Langston* | 231 | 1980-1994 | |
| 4 | Jon Matlack | 229 | 1981-1999 | |
| 5 | Bob Anderson | 221 | 1980-1997 | |
| 6 | Jeff Sellers | 204 | 1980-1998 | |
| 7 | Roy Oswalt# | 202 | 1988-2000 | |
| 7 | Barry Zito | 202 | 1980-1994 | |
| 9 | John Patterson | 189 | 1981-1997 | |
| 10 | Red Witt# | 187 | 1982-2000 | |
| 11 | Warren Spahn | 186 | 1980-1995 | |
| 12 | Esteban Loaiza# | 182 | 1988-2000 | |
| 13 | Bob Friend | 181 | 1980-1998 | |
| 13 | Bobby Shantz | 181 | 1981-1997 | |
| 15 | Robbie Ray | 179 | 1980-1992 | |
| 16 | Blake Snell# | 178 | 1988-2000 | |
| 17 | Chris Bosio | 177 | 1980-1998 | |
| 18 | Phil Niekro | 172 | 1983-1998 | |
| 19 | Don Kaiser# | 169 | 1984-2000 | |
| 20 | Walker Buehler# | 164 | 1988-2000 | |
| 21 | Sonny Siebert | 160 | 1982-1999 | |
| 22 | Gaylord Perry | 159 | 1980-1995 | |
| 23 | Jerad Eickhoff | 154 | 1981-1997 | |
| 24 | Ian Snell | 153 | 1980-1992 | |
| 25 | Foster Edwards# | 151 | 1983-2000 | |
| 26 | Ray Bare# | 150 | 1987-2000 | |
| 27 | Red Embree | 149 | 1981-1994 | |
| 28 | Bill Lee | 146 | 1983-1999 | |
| 28 | Kenta Maeda | 146 | 1982-1994 | |
| 28 | Craig Swan | 146 | 1980-1993 | |
| 31 | Jim Merritt | 145 | 1980-1994 | |
| 32 | Carl Hubbell# | 143 | 1992-2000 | |
| 33 | Sean Manaea# | 142 | 1987-2000 | |
| 33 | Ben Sheets# | 142 | 1983-1999 | |
| 35 | Kyle Freeland# | 139 | 1988-2000 | |
| 35 | Hal Newhouser | 139 | 1985-1998 | |
| 37 | Omar Olivares | 135 | 1980-1993 | |
| 38 | Bill Bevens | 134 | 1982-1993 | |
| 39 | Dustin Hermanson# | 133 | 1987-2000 | |
| 39 | John Miller# | 133 | 1986-2000 | |
| 41 | La Marr Hoyt# | 132 | 1985-2000 | |
| 42 | Luke Weaver# | 131 | 1992-2000 | |
| 43 | John Montefusco | 130 | 1986-1997 | |
| 44 | Joe Coleman | 129 | 1981-1994 | |
| 44 | Hiroki Kuroda# | 129 | 1993-2000 | |
| 46 | Jason Hammel# | 128 | 1989-2000 | |
| 47 | Tim Belcher# | 126 | 1987-2000 | |
| 47 | Jakob Junis | 126 | 1984-1997 | |
| 49 | Len Barker | 125 | 1980-1992 | |
| 49 | Brayan Bello# | 125 | 1987-2000 | |
| 51 | Jon Garland# | 124 | 1987-2000 | |
| 51 | Chad Gaudin | 124 | 1981-1993 | |
| 51 | Sam McDowell | 124 | 1986-1999 | |
| 54 | Mickey Harris# | 122 | 1986-1999 | |
| 54 | Daisuke Matsuzaka | 122 | 1986-1997 | |
| 56 | Jin-ho Cho | 121 | 1980-1991 | |
| 56 | Don Sutton# | 121 | 1987-1998 | |
| 56 | Jim Willis | 121 | 1980-1990 | |
| 59 | Art Ceccarelli | 120 | 1980-1989 | |
| 59 | Jimmy Key# | 120 | 1988-1997 | |
| 59 | Mickey Lolich# | 120 | 1988-1997 | |
| 59 | Urbano Lugo | 120 | 1980-1993 | |
| 63 | Todd Stottlemyre | 119 | 1983-1995 | |
| 64 | Dizzy Dean# | 117 | 1993-2000 | |
| 64 | Albie Lopez | 117 | 1984-2000 | |
| 66 | Blake Stein | 116 | 1980-1988 | |
| 67 | Sterling Hitchcock | 115 | 1980-1990 | |
| 67 | Kip Wells# | 115 | 1986-2000 | |
| 69 | Aaron Nola | 114 | 1989-1997 | |
| 70 | Steven Matz# | 112 | 1989-2000 | |
| 71 | Earl Francis# | 111 | 1991-2000 | |
| 71 | Barry Moore | 111 | 1980-1992 | |
| 73 | Jack Fisher# | 110 | 1994-2000 | |
| 74 | Dave Goltz# | 109 | 1990-1998 | |
| 75 | Chris Bassitt | 108 | 1986-1996 | |
| 75 | Luke Hochevar | 108 | 1980-1996 | |
| 77 | Dean Chance# | 107 | 1993-2000 | |
| 77 | Bob Moose | 107 | 1980-1989 | |
| 79 | Doug Rau# | 106 | 1992-2000 | |
| 79 | Scott Sanderson | 106 | 1986-1994 | |
| 81 | Wayne Schurr# | 105 | 1986-1999 | |
| 82 | Red Munger# | 104 | 1993-2000 | |
| 82 | Mike Nagy# | 104 | 1992-2000 | |
| 84 | Chris Holt# | 103 | 1993-2000 | |
| 84 | Jim Rooker | 103 | 1980-1990 | |
| 86 | Jim Golden# | 101 | 1990-2000 | |
| 86 | Tom Gordon# | 101 | 1993-2000 | |
| 88 | Dave Dravecky | 100 | 1987-1997 | |
| 88 | Rick Rhoden# | 100 | 1994-2000 | |
| 90 | Kevin McCarthy | 99 | 1985-1998 | |
| 90 | Aaron Small# | 99 | 1992-2000 | |
| 92 | Raul Alcantara# | 98 | 1982-2000 | |
| 92 | Jose Rijo# | 98 | 1993-2000 | |
| 94 | Odalis Perez | 97 | 1985-1995 | |
| 94 | Hub Pruett | 97 | 1980-1994 | |
| 96 | Tyler Anderson | 96 | 1980-1988 | |
| 96 | Gary Bell# | 96 | 1990-2000 | |
| 96 | Teddy Higuera# | 96 | 1992-2000 | |
| 99 | Ike Delock | 95 | 1985-1996 | |
| 99 | Bruce Howard# | 95 | 1990-2000 |
