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| Career Post-Season OSLG Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | OSLG | IP | Years | Single Season Leaderboard |
| 1. | Cy Buker | .2024 | 24.7 | 1945-1948 | |
| 2. | Ron Cook | .2088 | 27.3 | 1971-1981 | |
| 3. | Bob Ojeda | .2566 | 32.7 | 1986-1987 | |
| 4. | Tom Glavine | .2581 | 53.0 | 1988-1990 | |
| Rob Gardner | .2581 | 36.3 | 1970-1977 | ||
| 6. | Tom Qualters | .2596 | 145.3 | 1963-1971 | |
| 7. | Joey McLaughlin | .2614 | 92.7 | 1983-1988 | |
| 8. | Kevin Gross | .2616 | 65.7 | 1988-1990 | |
| 9. | Dave Geisel | .2675 | 44.7 | 1982-1987 | |
| 10. | Gus Keriazakos | .2696 | 82.7 | 1960-1965 | |
| 11. | Moe Drabowsky | .2697 | 26.0 | 1960-1968 | |
| 12. | Don Cardwell | .2778 | 25.7 | 1960-1965 | |
| 13. | Woodie Fryman | .2782 | 35.3 | 1966-1973 | |
| 14. | Mario Soto | .2783 | 32.3 | 1978-1987 | |
| 15. | Hal Newhouser | .2806 | 70.0 | 1939-1942 | |
| 16. | Danny Frisella | .2817 | 40.7 | 1968-1979 | |
| 17. | Lance Rautzhan | .2848 | 175.3 | 1979-1990 | |
| 18. | Howie Pollet | .2890 | 132.3 | 1941-1955 | |
| 19. | Diego Segui | .2892 | 24.3 | 1963-1969 | |
| 20. | Virgil Jester | .2895 | 31.3 | 1961-1961 | |
| 21. | J.R. Richard * | .2902 | 335.0 | 1973-1985 | |
| 22. | Roy Thomas | .2929 | 26.3 | 1982-1982 | |
| 23. | Jim Slaton | .2966 | 40.3 | 1974-1979 | |
| 24. | Dave Boswell | .2975 | 45.7 | 1966-1980 | |
| 25. | Don Stanhouse | .2981 | 30.7 | 1978-1985 | |
| 26. | Bud Daley | .2982 | 29.7 | 1965-1965 | |
| 27. | Charlie Williams | .3021 | 27.3 | 1972-1976 | |
| 28. | Charlie Beamon | .3030 | 34.3 | 1962-1970 | |
| 29. | Mike Torrez | .3059 | 175.0 | 1973-1983 | |
| 30. | Todd Frohwirth | .3061 | 25.3 | 1988-1990 | |
| 31. | John Hiller | .3064 | 238.3 | 1965-1978 | |
| 32. | Hal Reniff | .3127 | 200.3 | 1962-1977 | |
| 33. | Billy McCool | .3137 | 89.7 | 1968-1977 | |
| 34. | Dave Wehrmeister | .3140 | 23.3 | 1982-1986 | |
| 35. | Dutch Henry | .3142 | 59.3 | 1931-1933 | |
| 36. | Greg Minton | .3146 | 152.7 | 1976-1986 | |
| 37. | Paul Foytack | .3152 | 72.0 | 1955-1965 | |
| 38. | Mike Garman | .3155 | 152.3 | 1973-1988 | |
| 39. | Bill Wight | .3157 | 103.7 | 1949-1958 | |
| 40. | Bob Rush | .3173 | 55.0 | 1948-1954 | |
| 41. | Orel Hershiser | .3176 | 46.7 | 1986-1987 | |
| 42. | Juan Marichal * | .3198 | 228.6 | 1964-1972 | |
| 43. | Syd Cohen | .3205 | 21.3 | 1934-1940 | |
| 44. | Dave Smith | .3211 | 30.3 | 1982-1989 | |
| 45. | Sandy Koufax * | .3220 | 297.0 | 1958-1971 | |
| 46. | Bobby Witt | .3222 | 51.0 | 1988-1990 | |
| 47. | Jack Hallett | .3232 | 27.0 | 1945-1947 | |
| 48. | Bob Locker | .3235 | 27.3 | 1966-1968 | |
| 49. | Joe Grzenda | .3239 | 20.3 | 1962-1965 | |
| 50. | Ron Perranoski | .3243 | 53.0 | 1964-1969 |
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