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| Career Post-Season Strikeouts per 9IP Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts per 9IP | IP | Years | Single Season Leaderboard |
| 1. | Herb Score | 12.68 | 186.6 | 1958-1969 | |
| 2. | Ryne Duren | 11.80 | 34.3 | 1954-1963 | |
| 3. | Randy Johnson | 11.00 | 27.0 | 1990-1990 | |
| 4. | Skip Guinn | 9.85 | 35.7 | 1969-1981 | |
| 5. | Jack Meyer | 9.73 | 25.0 | 1963-1967 | |
| 6. | Don Sutton | 9.44 | 170.6 | 1966-1980 | |
| 7. | Bobby Witt | 9.35 | 51.0 | 1988-1990 | |
| 8. | Howie Pollet | 9.18 | 132.3 | 1941-1955 | |
| 9. | Jim Brewer * | 9.16 | 116.0 | 1964-1974 | |
| 10. | Marshall Bridges | 9.10 | 31.7 | 1961-1962 | |
| 11. | Dave Boswell | 9.07 | 45.7 | 1966-1980 | |
| 12. | Dan Plesac | 9.00 | 29.0 | 1987-1990 | |
| 13. | Don Demola | 8.92 | 109.0 | 1986-1990 | |
| 14. | Todd Frohwirth | 8.89 | 25.3 | 1988-1990 | |
| 15. | Danny Frisella | 8.86 | 40.7 | 1968-1979 | |
| 16. | Ted Gray | 8.85 | 60.0 | 1952-1961 | |
| 17. | Ken Dayley | 8.84 | 36.7 | 1986-1987 | |
| 18. | Masanori Murakami | 8.72 | 97.0 | 1968-1977 | |
| 19. | Sandy Koufax * | 8.67 | 297.0 | 1958-1971 | |
| 20. | Dick Drott | 8.64 | 50.0 | 1966-1970 | |
| 21. | Gus Keriazakos | 8.60 | 82.7 | 1960-1965 | |
| 22. | Frank Baumann | 8.43 | 47.0 | 1958-1967 | |
| 23. | Rich Gossage | 8.40 | 45.0 | 1973-1977 | |
| 24. | Gene Conley * | 8.35 | 125.0 | 1955-1966 | |
| 25. | Jesse Orosco | 8.32 | 70.3 | 1980-1990 | |
| 26. | Joe Presko | 8.29 | 58.7 | 1957-1964 | |
| 27. | Dave Beard | 8.21 | 41.7 | 1984-1990 | |
| 28. | Kent Peterson | 8.06 | 70.3 | 1952-1959 | |
| 29. | Dean Stone | 8.02 | 97.7 | 1956-1963 | |
| 30. | John Hiller | 8.01 | 238.3 | 1965-1978 | |
| 31. | Dick Lemay | 7.99 | 103.7 | 1966-1973 | |
| 32. | Jim Derrington | 7.97 | 55.3 | 1966-1974 | |
| 33. | Don Larsen | 7.93 | 30.7 | 1958-1963 | |
| 34. | Rich Bordi | 7.89 | 105.0 | 1982-1989 | |
| 35. | Johnny Vander Meer | 7.88 | 61.7 | 1947-1950 | |
| 36. | Charlie Beamon | 7.87 | 34.3 | 1962-1970 | |
| Stew Bolen | 7.87 | 34.3 | 1930-1937 | ||
| 38. | Dave Rucker | 7.84 | 31.0 | 1985-1990 | |
| 39. | Humberto Robinson | 7.82 | 48.3 | 1955-1960 | |
| 40. | Jose Deleon | 7.80 | 30.0 | 1988-1990 | |
| 41. | Mario Soto | 7.79 | 32.3 | 1978-1987 | |
| 42. | Steve Bedrosian | 7.74 | 47.7 | 1988-1990 | |
| 43. | Bart Johnson | 7.72 | 148.0 | 1976-1985 | |
| 44. | Bo McLaughlin | 7.66 | 44.7 | 1976-1987 | |
| 45. | Jerry Stephenson | 7.65 | 244.6 | 1968-1977 | |
| 46. | Gary Nolan * | 7.58 | 312.3 | 1968-1986 | |
| 47. | Tom Qualters | 7.56 | 145.3 | 1963-1971 | |
| 48. | Tom Butters | 7.55 | 22.7 | 1963-1967 | |
| 49. | Johnny Antonelli | 7.46 | 149.6 | 1948-1960 | |
| 50. | Bill Stoneman | 7.34 | 65.0 | 1969-1970 |
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