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| Single-Season Strikeouts per 9IP Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts per 9IP | IP | Year | Career Leaderboard |
| 1. | Herb Score | 13.45 | 298.3 | 1962 | |
| 2. | Herb Score | 13.30 | 274.7 | 1959 | |
| 3. | Herb Score | 13.28 | 250.0 | 1961 | |
| 4. | Herb Score | 13.07 | 306.3 | 1965 | |
| 5. | Herb Score | 13.02 | 262.0 | 1960 | |
| 6. | Herb Score | 12.87 | 227.3 | 1956 | |
| 7. | Herb Score | 12.75 | 307.0 | 1967 | |
| 8. | Herb Score | 12.64 | 324.7 | 1963 | |
| 9. | Herb Score | 12.50 | 311.0 | 1964 | |
| 10. | Herb Score | 12.02 | 255.3 | 1957 | |
| 11. | Herb Score | 12.01 | 272.7 | 1958 | |
| 12. | Herb Score | 12.00 | 276.7 | 1966 | |
| 13. | Dwight Gooden | 11.83 | 237.3 | 1989 | |
| 14. | Herb Score | 11.63 | 238.3 | 1969 | |
| 15. | Dwight Gooden | 11.47 | 237.7 | 1985 | |
| 16. | Dwight Gooden | 11.39 | 221.3 | 1987 | |
| 17. | Nolan Ryan | 11.34 | 289.7 | 1967 | |
| 18. | Dwight Gooden | 10.87 | 207.0 | 1988 | |
| 19. | Gus Keriazakos | 10.84 | 311.3 | 1960 | |
| 20. | Ryne Duren | 10.83 | 282.7 | 1961 | |
| 21. | Ryne Duren | 10.79 | 288.7 | 1960 | |
| 22. | Nolan Ryan | 10.78 | 251.3 | 1969 | |
| 23. | Don Sutton | 10.75 | 234.3 | 1968 | |
| 24. | Herb Score | 10.74 | 312.7 | 1968 | |
| 25. | Nolan Ryan | 10.73 | 253.3 | 1972 | |
| 26. | Nolan Ryan | 10.71 | 251.3 | 1971 | |
| 27. | Kent Peterson | 10.69 | 328.3 | 1961 | |
| 28. | Masanori Murakami | 10.65 | 227.3 | 1967 | |
| 29. | Nolan Ryan | 10.51 | 256.0 | 1970 | |
| 30. | Karl Spooner | 10.49 | 293.3 | 1959 | |
| 31. | Ryne Duren | 10.48 | 277.3 | 1959 | |
| 32. | Masanori Murakami | 10.47 | 288.0 | 1966 | |
| 33. | Ralph Lumenti | 10.44 | 237.0 | 1961 | |
| 34. | Charlie Kerfeld | 10.36 | 174.7 | 1990 | |
| 35. | Don Sutton | 10.34 | 269.0 | 1969 | |
| 36. | Jim Brewer * | 10.33 | 248.3 | 1972 | |
| 37. | Masanori Murakami | 10.30 | 240.3 | 1968 | |
| 38. | Duane Ward | 10.27 | 182.3 | 1990 | |
| 39. | Nolan Ryan | 10.26 | 300.0 | 1968 | |
| 40. | Charlie Beamon | 10.26 | 295.7 | 1967 | |
| 41. | Sandy Koufax * | 10.23 | 297.3 | 1960 | |
| 42. | Ryne Duren | 10.22 | 280.0 | 1956 | |
| 43. | Kent Peterson | 10.18 | 298.0 | 1959 | |
| 44. | Sandy Koufax * | 10.13 | 296.0 | 1961 | |
| 45. | Ryne Duren | 10.10 | 177.3 | 1957 | |
| 46. | Nolan Ryan | 10.07 | 263.7 | 1966 | |
| 47. | Gus Keriazakos | 10.07 | 306.7 | 1959 | |
| 48. | Nolan Ryan | 10.00 | 217.0 | 1973 | |
| 49. | Sandy Koufax * | 9.97 | 281.7 | 1959 | |
| 50. | Gus Keriazakos | 9.96 | 294.7 | 1965 | |
| 51. | Don Sutton | 9.94 | 259.0 | 1970 | |
| 52. | Jim Brewer * | 9.92 | 281.3 | 1966 | |
| 53. | Nolan Ryan | 9.91 | 213.3 | 1975 | |
| 54. | Gus Keriazakos | 9.90 | 239.0 | 1964 | |
| 55. | Jim Brewer * | 9.90 | 222.7 | 1973 | |
| 56. | Charlie Beamon | 9.86 | 212.7 | 1969 | |
| 57. | Jose Nunez | 9.85 | 166.3 | 1989 | |
| 58. | Jim Brewer * | 9.82 | 286.0 | 1968 | |
| 59. | Duane Ward | 9.79 | 193.0 | 1988 | |
| 60. | Kent Peterson | 9.77 | 168.7 | 1962 | |
| 61. | Kent Peterson | 9.76 | 263.7 | 1960 | |
| 62. | Jesse Orosco | 9.72 | 216.7 | 1985 | |
| 63. | Karl Spooner | 9.72 | 321.3 | 1957 | |
| 64. | Gus Keriazakos | 9.71 | 319.7 | 1961 | |
| 65. | Masanori Murakami | 9.69 | 285.0 | 1965 | |
| 66. | Don Sutton | 9.68 | 267.7 | 1971 | |
| 67. | Ryne Duren | 9.68 | 221.3 | 1964 | |
| 68. | Masanori Murakami | 9.67 | 233.7 | 1969 | |
| 69. | Sandy Koufax * | 9.66 | 322.3 | 1967 | |
| 70. | Dave Beard | 9.66 | 192.0 | 1989 | |
| 71. | Jim Brewer * | 9.65 | 277.0 | 1964 | |
| 72. | Karl Spooner | 9.64 | 314.7 | 1958 | |
| 73. | Charlie Beamon | 9.64 | 235.3 | 1970 | |
| 74. | Herb Score | 9.63 | 185.0 | 1970 | |
| 75. | Randy Johnson | 9.53 | 238.0 | 1990 | |
| 76. | Mark Littell | 9.52 | 172.0 | 1985 | |
| 77. | Jack Meyer | 9.52 | 253.3 | 1957 | |
| 78. | Dan Plesac | 9.52 | 186.3 | 1990 | |
| 79. | Masanori Murakami | 9.51 | 235.7 | 1971 | |
| 80. | Ted Gray | 9.45 | 174.3 | 1959 | |
| 81. | Ted Gray | 9.44 | 299.3 | 1953 | |
| 82. | Johnny Antonelli | 9.43 | 325.3 | 1959 | |
| 83. | Charlie Beamon | 9.43 | 243.3 | 1968 | |
| 84. | Ryne Duren | 9.41 | 267.7 | 1958 | |
| 85. | Lance McCullers | 9.40 | 171.3 | 1989 | |
| 86. | Karl Spooner | 9.39 | 286.7 | 1961 | |
| 87. | Herb Score | 9.38 | 228.3 | 1971 | |
| 88. | Jim Brewer * | 9.38 | 191.0 | 1971 | |
| 89. | Rich Bordi | 9.36 | 214.3 | 1990 | |
| 90. | Karl Spooner | 9.36 | 305.7 | 1965 | |
| 91. | Charlie Kerfeld | 9.34 | 192.7 | 1989 | |
| 92. | Dan Plesac | 9.33 | 189.0 | 1988 | |
| 93. | Jack Meyer | 9.32 | 252.0 | 1956 | |
| 94. | Ted Gray | 9.31 | 317.0 | 1958 | |
| 95. | Ryne Duren | 9.31 | 206.0 | 1962 | |
| 96. | Sandy Koufax * | 9.27 | 330.0 | 1968 | |
| 97. | Howie Pollet | 9.27 | 301.0 | 1953 | |
| 98. | Gus Keriazakos | 9.27 | 313.7 | 1962 | |
| 99. | Gus Keriazakos | 9.25 | 306.3 | 1963 | |
| 100. | Roger Clemens | 9.25 | 201.3 | 1989 | |
| 101. | Ryne Duren | 9.25 | 289.0 | 1955 | |
| 102. | Karl Spooner | 9.24 | 325.3 | 1956 | |
| 103. | Dave Beard | 9.23 | 192.0 | 1988 | |
| 104. | Eric Nolte | 9.23 | 185.3 | 1990 | |
| 105. | Ted Gray | 9.22 | 233.3 | 1956 | |
| 106. | Jim Brewer * | 9.20 | 285.7 | 1962 | |
| 107. | Randy Johnson | 9.19 | 241.0 | 1989 | |
| 108. | Duane Ward | 9.16 | 171.0 | 1987 | |
| 109. | Howie Pollet | 9.13 | 307.7 | 1956 | |
| 110. | Don Sutton | 9.11 | 263.7 | 1972 | |
| 111. | Kent Peterson | 9.09 | 235.7 | 1956 | |
| 112. | Charlie Beamon | 9.07 | 293.7 | 1964 | |
| 113. | Gus Keriazakos | 9.07 | 255.0 | 1966 | |
| 114. | Bobby Witt | 9.05 | 227.7 | 1988 | |
| 115. | Kent Peterson | 9.05 | 323.3 | 1955 | |
| 116. | Charlie Beamon | 9.04 | 310.7 | 1965 | |
| 117. | Karl Spooner | 9.03 | 291.0 | 1955 | |
| 118. | Sandy Koufax * | 9.01 | 316.7 | 1966 | |
| 119. | John Hiller | 9.00 | 221.0 | 1971 | |
| 120. | Johnny Antonelli | 8.99 | 323.3 | 1961 | |
| 121. | Jim Brewer * | 8.98 | 283.7 | 1961 | |
| 122. | Masanori Murakami | 8.97 | 216.7 | 1973 | |
| 123. | Masanori Murakami | 8.96 | 228.0 | 1970 | |
| 124. | Karl Spooner | 8.94 | 259.7 | 1966 | |
| 125. | Roger Clemens | 8.94 | 240.7 | 1990 | |
| 126. | Charlie Beamon | 8.93 | 273.0 | 1963 | |
| 127. | Dick Lemay | 8.93 | 250.0 | 1966 | |
| 128. | Ralph Lumenti | 8.93 | 206.7 | 1966 | |
| 129. | Sandy Koufax * | 8.93 | 325.7 | 1964 | |
| 130. | Jim Brewer * | 8.92 | 299.7 | 1967 | |
| 131. | Jim Maloney | 8.91 | 221.3 | 1970 | |
| 132. | Sandy Koufax * | 8.90 | 337.7 | 1962 | |
| 133. | Don Sutton | 8.89 | 313.7 | 1967 | |
| 134. | Jim Brewer * | 8.89 | 256.0 | 1965 | |
| 135. | Johnny Antonelli | 8.89 | 308.7 | 1960 | |
| 136. | Warren Spahn * | 8.88 | 342.7 | 1960 | |
| 137. | Mark Langston | 8.87 | 223.3 | 1985 | |
| 138. | Don Sutton | 8.85 | 261.3 | 1975 | |
| 139. | Jim Derrington | 8.84 | 251.3 | 1969 | |
| 140. | Bart Johnson | 8.84 | 247.3 | 1984 | |
| 141. | Tom Qualters | 8.84 | 294.3 | 1961 | |
| 142. | Randy Johnson | 8.83 | 242.7 | 1988 | |
| 143. | Jack Meyer | 8.79 | 184.3 | 1958 | |
| 144. | Jim Maloney | 8.78 | 232.7 | 1965 | |
| 145. | Don Sutton | 8.77 | 322.3 | 1966 | |
| 146. | Karl Spooner | 8.77 | 232.0 | 1962 | |
| 147. | Gus Keriazakos | 8.76 | 253.7 | 1968 | |
| 148. | Frank Baumann | 8.75 | 302.3 | 1960 | |
| 149. | Bobby Witt | 8.75 | 225.3 | 1989 | |
| 150. | Joe Presko | 8.74 | 326.3 | 1961 | |
| 151. | Bill Caudill | 8.74 | 172.0 | 1989 | |
| 152. | Ralph Lumenti | 8.73 | 178.3 | 1965 | |
| 153. | Karl Spooner | 8.72 | 303.3 | 1964 | |
| 154. | Ted Gray | 8.72 | 299.3 | 1955 | |
| 155. | Sandy Koufax * | 8.71 | 272.7 | 1971 | |
| 156. | Ralph Lumenti | 8.71 | 207.7 | 1962 | |
| 157. | Joey McLaughlin | 8.71 | 187.0 | 1990 | |
| 158. | Frank Baumann | 8.70 | 274.0 | 1964 | |
| 159. | Humberto Robinson | 8.70 | 313.3 | 1960 | |
| 160. | Rich Bordi | 8.70 | 259.7 | 1988 | |
| 161. | Rich Bordi | 8.69 | 242.3 | 1989 | |
| 162. | Nolan Ryan | 8.69 | 201.0 | 1977 | |
| 163. | Sandy Koufax * | 8.68 | 266.3 | 1970 | |
| 164. | Ken Dayley | 8.68 | 224.0 | 1989 | |
| 165. | Gene Conley * | 8.68 | 335.0 | 1959 | |
| 166. | Ted Gray | 8.68 | 240.7 | 1954 | |
| 167. | Gene Conley * | 8.67 | 343.7 | 1962 | |
| 168. | Ralph Lumenti | 8.65 | 286.0 | 1964 | |
| 169. | Dean Stone | 8.65 | 281.0 | 1959 | |
| 170. | Gus Keriazakos | 8.64 | 255.3 | 1958 | |
| 171. | Masanori Murakami | 8.63 | 243.0 | 1972 | |
| 172. | Gene Conley * | 8.62 | 337.3 | 1960 | |
| 173. | George Brunet | 8.61 | 263.3 | 1960 | |
| 174. | Sandy Koufax * | 8.61 | 176.7 | 1955 | |
| 175. | Mark Langston | 8.61 | 251.0 | 1986 | |
| 176. | J.R. Richard * | 8.59 | 286.0 | 1973 | |
| 177. | Larry Sherry | 8.59 | 217.0 | 1961 | |
| 178. | Sam McDowell | 8.58 | 269.7 | 1969 | |
| 179. | Warren Spahn * | 8.57 | 366.3 | 1958 | |
| 180. | Sandy Koufax * | 8.57 | 308.7 | 1958 | |
| 181. | Gene Conley * | 8.57 | 349.7 | 1961 | |
| 182. | Don Newcombe | 8.56 | 252.3 | 1960 | |
| 183. | Ken Dayley | 8.55 | 180.0 | 1990 | |
| 184. | J.R. Richard * | 8.55 | 232.7 | 1974 | |
| 185. | Humberto Robinson | 8.53 | 314.3 | 1961 | |
| 186. | Sandy Koufax * | 8.52 | 214.3 | 1969 | |
| 187. | Don Demola | 8.51 | 227.3 | 1986 | |
| 188. | Don Demola | 8.51 | 202.0 | 1990 | |
| 189. | Don Drysdale | 8.51 | 255.0 | 1967 | |
| 190. | Ralph Lumenti | 8.51 | 291.0 | 1963 | |
| 191. | Dick Drott | 8.50 | 273.3 | 1967 | |
| 192. | Sandy Koufax * | 8.49 | 277.7 | 1963 | |
| 193. | Tom Qualters | 8.49 | 294.7 | 1962 | |
| 194. | Balor Moore | 8.48 | 243.0 | 1984 | |
| 195. | Randy Myers | 8.48 | 190.0 | 1989 | |
| 196. | Johnny Antonelli | 8.46 | 308.3 | 1962 | |
| 197. | Don Drysdale | 8.45 | 313.0 | 1968 | |
| 198. | Dick Drott | 8.44 | 194.0 | 1968 | |
| 199. | John Hiller | 8.44 | 225.0 | 1968 | |
| 200. | John Hiller | 8.43 | 222.0 | 1970 | |
| 201. | Dave Laroche | 8.43 | 215.7 | 1976 | |
| 202. | Billy Pierce | 8.43 | 309.7 | 1960 | |
| 203. | Warren Spahn * | 8.43 | 276.7 | 1959 | |
| 204. | Johnny Antonelli | 8.42 | 322.7 | 1964 | |
| 205. | Sandy Koufax * | 8.42 | 248.0 | 1972 | |
| 206. | Kent Peterson | 8.42 | 299.3 | 1951 | |
| 207. | Kent Peterson | 8.41 | 263.3 | 1957 | |
| 208. | Jim Maloney | 8.40 | 236.7 | 1969 | |
| 209. | Tom Henke | 8.40 | 175.7 | 1990 | |
| 210. | Billy Pierce | 8.40 | 301.0 | 1959 | |
| 211. | Karl Spooner | 8.40 | 300.0 | 1963 | |
| 212. | Jim Brewer * | 8.39 | 223.0 | 1975 | |
| 213. | George Brunet | 8.39 | 280.0 | 1961 | |
| 214. | Ken Dayley | 8.39 | 196.3 | 1988 | |
| 215. | Rollie Fingers | 8.39 | 254.3 | 1973 | |
| 216. | Sam McDowell | 8.37 | 241.0 | 1961 | |
| 217. | Don Sutton | 8.36 | 259.3 | 1977 | |
| 218. | Dick Lemay | 8.36 | 268.0 | 1965 | |
| 219. | Nolan Ryan | 8.36 | 234.7 | 1974 | |
| 220. | Bart Johnson | 8.36 | 275.7 | 1981 | |
| 221. | Lance McCullers | 8.35 | 170.3 | 1990 | |
| 222. | Warren Spahn * | 8.35 | 367.7 | 1956 | |
| 223. | Don Sutton | 8.34 | 235.3 | 1973 | |
| 224. | J.R. Richard * | 8.34 | 239.7 | 1985 | |
| 225. | Ralph Lumenti | 8.32 | 226.0 | 1967 | |
| 226. | Ted Gray | 8.32 | 291.0 | 1957 | |
| 227. | Dick Selma | 8.32 | 238.0 | 1971 | |
| 228. | Joey McLaughlin | 8.32 | 245.7 | 1986 | |
| 229. | John Hiller | 8.31 | 205.7 | 1972 | |
| 230. | Mike Warren | 8.31 | 204.7 | 1989 | |
| 231. | Sid Fernandez | 8.31 | 186.3 | 1984 | |
| 232. | Joe Beckwith | 8.31 | 225.3 | 1986 | |
| 233. | Howie Pollet | 8.31 | 306.7 | 1954 | |
| 234. | Balor Moore | 8.29 | 267.0 | 1980 | |
| 235. | Balor Moore | 8.29 | 262.7 | 1985 | |
| 236. | Ralph Lumenti | 8.28 | 182.7 | 1971 | |
| 237. | Dick Drott | 8.28 | 318.7 | 1960 | |
| 238. | Ralph Lumenti | 8.28 | 231.7 | 1969 | |
| 239. | Johnny Antonelli | 8.27 | 314.3 | 1958 | |
| 240. | Tom Qualters | 8.27 | 277.7 | 1965 | |
| 241. | Rod Scurry | 8.26 | 182.0 | 1984 | |
| 242. | Bo Belinsky | 8.25 | 288.0 | 1962 | |
| 243. | Gary Kroll | 8.24 | 208.7 | 1971 | |
| 244. | George Lauzerique | 8.24 | 231.7 | 1972 | |
| 245. | Kent Peterson | 8.23 | 289.7 | 1958 | |
| 246. | Humberto Robinson | 8.22 | 300.0 | 1959 | |
| 247. | Jim Brewer * | 8.22 | 241.0 | 1970 | |
| 248. | Mark Langston | 8.22 | 218.0 | 1987 | |
| 249. | Dick Drott | 8.20 | 233.7 | 1970 | |
| 250. | J.R. Richard * | 8.20 | 214.0 | 1980 | |
| 251. | Warren Spahn * | 8.18 | 348.7 | 1955 | |
| 252. | Joe Beckwith | 8.18 | 193.7 | 1988 | |
| 253. | Dave Laroche | 8.18 | 211.3 | 1972 | |
| 254. | Billy Pierce | 8.17 | 302.0 | 1961 | |
| 255. | Johnny Vander Meer | 8.16 | 305.3 | 1948 | |
| 256. | Dick Drott | 8.15 | 194.3 | 1971 | |
| 257. | Randy Myers | 8.15 | 162.3 | 1990 | |
| 258. | Carl Scheib | 8.15 | 334.7 | 1960 | |
| 259. | Gus Keriazakos | 8.15 | 169.0 | 1967 | |
| 260. | Pat Malone | 8.14 | 246.7 | 1940 | |
| 261. | Ralph Lumenti | 8.14 | 281.0 | 1968 | |
| 262. | Tom Underwood | 8.13 | 218.0 | 1989 | |
| 263. | Matt Williams | 8.13 | 197.0 | 1988 | |
| 264. | Cecil Butler | 8.13 | 282.3 | 1967 | |
| 265. | Howie Pollet | 8.13 | 288.0 | 1955 | |
| 266. | Tom Underwood | 8.12 | 185.0 | 1988 | |
| 267. | Balor Moore | 8.12 | 248.3 | 1982 | |
| 268. | Jim Brewer * | 8.11 | 219.7 | 1969 | |
| 269. | Luis Arroyo | 8.11 | 258.7 | 1959 | |
| 270. | Jim Maloney | 8.10 | 264.3 | 1968 | |
| 271. | Bill Caudill | 8.09 | 179.0 | 1988 | |
| 272. | Frank Baumann | 8.09 | 278.0 | 1962 | |
| 273. | Jim Brewer * | 8.09 | 201.3 | 1974 | |
| 274. | Howie Pollet | 8.08 | 304.0 | 1957 | |
| 275. | Balor Moore | 8.07 | 284.3 | 1981 | |
| 276. | Tom Qualters | 8.07 | 292.3 | 1967 | |
| 277. | Joey McLaughlin | 8.06 | 166.3 | 1988 | |
| 278. | Sandy Koufax * | 8.05 | 275.0 | 1956 | |
| 279. | Jim Derrington | 8.04 | 172.3 | 1967 | |
| 280. | Carl Scheib | 8.04 | 341.3 | 1959 | |
| 281. | Moe Drabowsky | 8.03 | 259.0 | 1961 | |
| 282. | George Brunet | 8.02 | 295.0 | 1962 | |
| 283. | Bud Daley | 8.02 | 321.0 | 1961 | |
| 284. | Johnny Vander Meer | 8.02 | 317.7 | 1944 | |
| 285. | Kent Peterson | 8.01 | 297.7 | 1953 | |
| 286. | Mark Littell | 8.01 | 203.3 | 1981 | |
| 287. | Howie Nunn | 8.01 | 166.3 | 1965 | |
| 288. | Kent Peterson | 8.01 | 220.3 | 1963 | |
| 289. | Sandy Koufax * | 8.00 | 276.7 | 1957 | |
| 290. | Dean Stone | 8.00 | 294.7 | 1958 | |
| 291. | Frank Baumann | 8.00 | 309.3 | 1963 | |
| 292. | Billy McCool | 7.99 | 220.7 | 1973 | |
| 293. | George Brunet | 7.99 | 271.3 | 1969 | |
| 294. | Kevin Gross | 7.99 | 246.7 | 1989 | |
| Humberto Robinson | 7.99 | 246.7 | 1958 | ||
| 296. | Mark Littell | 7.98 | 168.0 | 1978 | |
| 297. | Carl Scheib | 7.98 | 313.7 | 1958 | |
| 298. | Balor Moore | 7.98 | 216.7 | 1986 | |
| 299. | Charlie Beamon | 7.97 | 237.0 | 1966 | |
| 300. | Don Sutton | 7.97 | 213.3 | 1974 |
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