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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | IP | Year | Career Leaderboard |
| 1. | Herb Score | 456 | 324.7 | 1963 | |
| 2. | Herb Score | 446 | 298.3 | 1962 | |
| 3. | Herb Score | 445 | 306.3 | 1965 | |
| 4. | Herb Score | 435 | 307.0 | 1967 | |
| 5. | Herb Score | 432 | 311.0 | 1964 | |
| 6. | Herb Score | 406 | 274.7 | 1959 | |
| 7. | Kent Peterson | 390 | 328.3 | 1961 | |
| 8. | Herb Score | 379 | 262.0 | 1960 | |
| 9. | Gus Keriazakos | 375 | 311.3 | 1960 | |
| 10. | Herb Score | 373 | 312.7 | 1968 | |
| 11. | Herb Score | 369 | 276.7 | 1966 | |
| Herb Score | 369 | 250.0 | 1961 | ||
| 13. | Nolan Ryan | 365 | 289.7 | 1967 | |
| 14. | Herb Score | 364 | 272.7 | 1958 | |
| 15. | Warren Spahn * | 349 | 366.3 | 1958 | |
| 16. | Karl Spooner | 347 | 321.3 | 1957 | |
| 17. | Sandy Koufax * | 346 | 322.3 | 1967 | |
| Ryne Duren | 346 | 288.7 | 1960 | ||
| 19. | Gus Keriazakos | 345 | 319.7 | 1961 | |
| 20. | Gus Keriazakos | 343 | 306.7 | 1959 | |
| 21. | Nolan Ryan | 342 | 300.0 | 1968 | |
| Karl Spooner | 342 | 293.3 | 1959 | ||
| 23. | Johnny Antonelli | 341 | 325.3 | 1959 | |
| Herb Score | 341 | 255.3 | 1957 | ||
| Warren Spahn * | 341 | 367.7 | 1956 | ||
| 26. | Sandy Koufax * | 340 | 330.0 | 1968 | |
| Ryne Duren | 340 | 282.7 | 1961 | ||
| 28. | Warren Spahn * | 338 | 342.7 | 1960 | |
| Sandy Koufax * | 338 | 297.3 | 1960 | ||
| 30. | Charlie Beamon | 337 | 295.7 | 1967 | |
| Kent Peterson | 337 | 298.0 | 1959 | ||
| Karl Spooner | 337 | 314.7 | 1958 | ||
| 33. | Warren Spahn * | 336 | 379.3 | 1957 | |
| 34. | Masanori Murakami | 335 | 288.0 | 1966 | |
| 35. | Sandy Koufax * | 334 | 337.7 | 1962 | |
| Karl Spooner | 334 | 325.3 | 1956 | ||
| 37. | Gene Conley * | 333 | 349.7 | 1961 | |
| Sandy Koufax * | 333 | 296.0 | 1961 | ||
| 39. | Gene Conley * | 331 | 343.7 | 1962 | |
| 40. | Ted Gray | 328 | 317.0 | 1958 | |
| 41. | Gus Keriazakos | 326 | 294.7 | 1965 | |
| Warren Spahn * | 326 | 371.0 | 1952 | ||
| 43. | Herb Score | 325 | 227.3 | 1956 | |
| Kent Peterson | 325 | 323.3 | 1955 | ||
| 45. | Sandy Koufax * | 323 | 325.7 | 1964 | |
| Gus Keriazakos | 323 | 313.7 | 1962 | ||
| Johnny Antonelli | 323 | 323.3 | 1961 | ||
| Gene Conley * | 323 | 337.3 | 1960 | ||
| Gene Conley * | 323 | 335.0 | 1959 | ||
| Ryne Duren | 323 | 277.3 | 1959 | ||
| 51. | Warren Spahn * | 322 | 378.7 | 1953 | |
| 52. | Karl Spooner | 318 | 305.7 | 1965 | |
| Ryne Duren | 318 | 280.0 | 1956 | ||
| 54. | Sandy Koufax * | 317 | 316.7 | 1966 | |
| Joe Presko | 317 | 326.3 | 1961 | ||
| Warren Spahn * | 317 | 348.7 | 1955 | ||
| 57. | Gus Keriazakos | 315 | 306.3 | 1963 | |
| 58. | Don Sutton | 314 | 322.3 | 1966 | |
| Ted Gray | 314 | 299.3 | 1953 | ||
| 60. | Dwight Gooden | 312 | 237.3 | 1989 | |
| Jim Brewer * | 312 | 286.0 | 1968 | ||
| Charlie Beamon | 312 | 310.7 | 1965 | ||
| Sandy Koufax * | 312 | 281.7 | 1959 | ||
| Howie Pollet | 312 | 307.7 | 1956 | ||
| 65. | Don Sutton | 310 | 313.7 | 1967 | |
| Jim Brewer * | 310 | 281.3 | 1966 | ||
| Howie Pollet | 310 | 301.0 | 1953 | ||
| 68. | Don Sutton | 309 | 269.0 | 1969 | |
| 69. | Herb Score | 308 | 238.3 | 1969 | |
| 70. | Masanori Murakami | 307 | 285.0 | 1965 | |
| 71. | Warren Spahn * | 306 | 374.7 | 1951 | |
| 72. | Johnny Antonelli | 305 | 308.7 | 1960 | |
| Carl Scheib | 305 | 341.3 | 1959 | ||
| 74. | Dwight Gooden | 303 | 237.7 | 1985 | |
| Carl Scheib | 303 | 334.7 | 1960 | ||
| Humberto Robinson | 303 | 313.3 | 1960 | ||
| 77. | Nolan Ryan | 302 | 253.3 | 1972 | |
| Johnny Antonelli | 302 | 322.7 | 1964 | ||
| 79. | Nolan Ryan | 301 | 251.3 | 1969 | |
| Jim Maloney | 301 | 340.0 | 1962 | ||
| 81. | Chuck Stobbs * | 300 | 368.0 | 1960 | |
| 82. | Nolan Ryan | 299 | 251.3 | 1971 | |
| Nolan Ryan | 299 | 256.0 | 1970 | ||
| Karl Spooner | 299 | 286.7 | 1961 | ||
| 85. | Humberto Robinson | 298 | 314.3 | 1961 | |
| 86. | Jim Brewer * | 297 | 299.7 | 1967 | |
| Jim Brewer * | 297 | 277.0 | 1964 | ||
| Ryne Duren | 297 | 289.0 | 1955 | ||
| 89. | Charlie Beamon | 296 | 293.7 | 1964 | |
| 90. | Nolan Ryan | 295 | 263.7 | 1966 | |
| 91. | Don Drysdale | 294 | 313.0 | 1968 | |
| Karl Spooner | 294 | 303.3 | 1964 | ||
| Frank Baumann | 294 | 302.3 | 1960 | ||
| Sandy Koufax * | 294 | 308.7 | 1958 | ||
| 95. | Dick Drott | 293 | 318.7 | 1960 | |
| Warren Spahn * | 293 | 376.7 | 1954 | ||
| 97. | Jim Brewer * | 292 | 285.7 | 1962 | |
| Chuck Stobbs * | 292 | 375.3 | 1961 | ||
| Karl Spooner | 292 | 291.0 | 1955 | ||
| 100. | Billy Hoeft | 291 | 349.0 | 1965 | |
| Joe Presko | 291 | 340.3 | 1960 | ||
| Johnny Antonelli | 291 | 335.7 | 1957 | ||
| 103. | Johnny Antonelli | 290 | 308.3 | 1962 | |
| Billy Pierce | 290 | 309.7 | 1960 | ||
| Ted Gray | 290 | 299.3 | 1955 | ||
| 106. | Tom Qualters | 289 | 294.3 | 1961 | |
| Johnny Antonelli | 289 | 314.3 | 1958 | ||
| 108. | Don Sutton | 288 | 267.7 | 1971 | |
| 109. | Don Drysdale | 287 | 351.7 | 1964 | |
| Gene Conley * | 287 | 334.3 | 1963 | ||
| 111. | Don Sutton | 286 | 259.0 | 1970 | |
| Don Drysdale | 286 | 351.3 | 1965 | ||
| Gene Conley * | 286 | 346.0 | 1965 | ||
| Bud Daley | 286 | 321.0 | 1961 | ||
| Kent Peterson | 286 | 263.7 | 1960 | ||
| 116. | Jim Brewer * | 285 | 248.3 | 1972 | |
| 117. | Gene Conley * | 284 | 342.3 | 1958 | |
| 118. | Ray Culp | 283 | 324.7 | 1963 | |
| Jim Brewer * | 283 | 283.7 | 1961 | ||
| Howie Pollet | 283 | 306.7 | 1954 | ||
| Johnny Vander Meer | 283 | 317.7 | 1944 | ||
| 122. | Billy Pierce | 281 | 301.0 | 1959 | |
| 123. | Dwight Gooden | 280 | 221.3 | 1987 | |
| Juan Marichal * | 280 | 386.3 | 1968 | ||
| Don Sutton | 280 | 234.3 | 1968 | ||
| Billy Hoeft | 280 | 354.3 | 1966 | ||
| Karl Spooner | 280 | 300.0 | 1963 | ||
| Ryne Duren | 280 | 267.7 | 1958 | ||
| Johnny Antonelli | 280 | 324.3 | 1956 | ||
| Kent Peterson | 280 | 299.3 | 1951 | ||
| 131. | Tom Qualters | 278 | 294.7 | 1962 | |
| Carl Scheib | 278 | 313.7 | 1958 | ||
| Warren Spahn * | 278 | 369.0 | 1950 | ||
| 134. | Johnny Vander Meer | 277 | 305.3 | 1948 | |
| 135. | Cecil Butler | 276 | 315.7 | 1968 | |
| Joey Jay | 276 | 342.0 | 1963 | ||
| Johnny Vander Meer | 276 | 327.7 | 1943 | ||
| 138. | Masanori Murakami | 275 | 240.3 | 1968 | |
| Ralph Lumenti | 275 | 286.0 | 1964 | ||
| Frank Baumann | 275 | 309.3 | 1963 | ||
| Ralph Lumenti | 275 | 291.0 | 1963 | ||
| Ralph Lumenti | 275 | 237.0 | 1961 | ||
| Carl Scheib | 275 | 343.7 | 1957 | ||
| 144. | Joey Jay | 274 | 321.3 | 1961 | |
| Billy Pierce | 274 | 302.0 | 1961 | ||
| Humberto Robinson | 274 | 300.0 | 1959 | ||
| 147. | J.R. Richard * | 273 | 286.0 | 1973 | |
| Juan Marichal * | 273 | 379.7 | 1967 | ||
| Billy Hoeft | 273 | 345.0 | 1964 | ||
| Bob Gibson | 273 | 321.7 | 1961 | ||
| Howie Pollet | 273 | 304.0 | 1957 | ||
| 152. | Charlie Beamon | 271 | 273.0 | 1963 | |
| 153. | Dean Stone | 270 | 281.0 | 1959 | |
| 154. | Masanori Murakami | 269 | 227.3 | 1967 | |
| Ted Gray | 269 | 291.0 | 1957 | ||
| 156. | George Brunet | 268 | 328.7 | 1968 | |
| Joe Horlen | 268 | 328.7 | 1967 | ||
| Jack Meyer | 268 | 253.3 | 1957 | ||
| 159. | Don Sutton | 267 | 263.7 | 1972 | |
| 160. | John Gelnar | 266 | 311.3 | 1968 | |
| 161. | Dean Chance | 265 | 355.7 | 1968 | |
| Frank Baumann | 265 | 274.0 | 1964 | ||
| Juan Marichal * | 265 | 378.3 | 1963 | ||
| Kent Peterson | 265 | 289.7 | 1958 | ||
| Kent Peterson | 265 | 297.7 | 1953 | ||
| 166. | Bart Johnson | 264 | 307.0 | 1985 | |
| Sandy Koufax * | 264 | 272.7 | 1971 | ||
| Bo Belinsky | 264 | 288.0 | 1962 | ||
| Joey Jay | 264 | 320.7 | 1960 | ||
| Pat Malone | 264 | 335.0 | 1938 | ||
| 171. | Gene Conley * | 263 | 325.7 | 1966 | |
| Gus Keriazakos | 263 | 239.0 | 1964 | ||
| George Brunet | 263 | 295.0 | 1962 | ||
| Johnny Vander Meer | 263 | 327.3 | 1946 | ||
| 175. | George Brunet | 262 | 330.7 | 1967 | |
| Tom Qualters | 262 | 292.3 | 1967 | ||
| George Brunet | 262 | 301.7 | 1966 | ||
| Sandy Koufax * | 262 | 277.7 | 1963 | ||
| Dean Stone | 262 | 294.7 | 1958 | ||
| Kent Peterson | 262 | 302.7 | 1954 | ||
| 181. | Don Larsen | 261 | 331.7 | 1965 | |
| Bob Gibson | 261 | 340.3 | 1962 | ||
| George Brunet | 261 | 280.0 | 1961 | ||
| Bob Gibson | 261 | 353.0 | 1960 | ||
| Jack Meyer | 261 | 252.0 | 1956 | ||
| 186. | Dick Drott | 260 | 305.7 | 1963 | |
| George Brunet | 260 | 304.7 | 1963 | ||
| Chuck Stobbs * | 260 | 355.3 | 1962 | ||
| Billy Pierce | 260 | 294.3 | 1958 | ||
| Howie Pollet | 260 | 288.0 | 1955 | ||
| 191. | Ike Delock | 259 | 346.0 | 1960 | |
| Warren Spahn * | 259 | 276.7 | 1959 | ||
| Johnny Antonelli | 259 | 311.0 | 1955 | ||
| Warren Spahn * | 259 | 367.7 | 1949 | ||
| 195. | Dick Drott | 258 | 273.3 | 1967 | |
| Don Drysdale | 258 | 304.7 | 1966 | ||
| Karl Spooner | 258 | 259.7 | 1966 | ||
| 198. | Don Sutton | 257 | 261.3 | 1975 | |
| Sandy Koufax * | 257 | 266.3 | 1970 | ||
| Sam McDowell | 257 | 269.7 | 1969 | ||
| Luis Tiant | 257 | 362.7 | 1968 | ||
| Steve Carlton * | 257 | 331.0 | 1968 | ||
| Gus Keriazakos | 257 | 255.0 | 1966 | ||
| 204. | Bart Johnson | 256 | 275.7 | 1981 | |
| George Brunet | 256 | 311.0 | 1964 | ||
| Kent Peterson | 256 | 313.7 | 1952 | ||
| Warren Spahn * | 256 | 378.3 | 1948 | ||
| 208. | Balor Moore | 255 | 284.3 | 1981 | |
| Charlie Beamon | 255 | 243.3 | 1968 | ||
| Cecil Butler | 255 | 282.3 | 1967 | ||
| Tom Qualters | 255 | 277.7 | 1965 | ||
| Joe Presko | 255 | 331.3 | 1959 | ||
| Chuck Stobbs * | 255 | 363.7 | 1958 | ||
| Don Newcombe | 255 | 322.3 | 1955 | ||
| Pat Malone | 255 | 338.7 | 1936 | ||
| 216. | Rollie Sheldon | 254 | 342.3 | 1968 | |
| Ralph Lumenti | 254 | 281.0 | 1968 | ||
| Gene Conley * | 254 | 347.7 | 1967 | ||
| Juan Marichal * | 254 | 363.3 | 1966 | ||
| Joey Jay | 254 | 322.7 | 1959 | ||
| 221. | Joe Moeller * | 253 | 351.7 | 1968 | |
| Jim Brewer * | 253 | 256.0 | 1965 | ||
| Don Newcombe | 253 | 320.0 | 1956 | ||
| 224. | Randy Johnson | 252 | 238.0 | 1990 | |
| Charlie Beamon | 252 | 235.3 | 1970 | ||
| Ramon Monzant | 252 | 300.7 | 1961 | ||
| George Brunet | 252 | 263.3 | 1960 | ||
| Howie Pollet | 252 | 288.7 | 1952 | ||
| Howie Pollet | 252 | 285.3 | 1951 | ||
| Paul Dean * | 252 | 358.7 | 1937 | ||
| 231. | Rich Bordi | 251 | 259.7 | 1988 | |
| Masanori Murakami | 251 | 233.7 | 1969 | ||
| Frank Baumann | 251 | 311.0 | 1968 | ||
| Tom Qualters | 251 | 289.0 | 1964 | ||
| Ike Delock | 251 | 324.7 | 1963 | ||
| Billy Hoeft | 251 | 351.7 | 1962 | ||
| Gene Conley * | 251 | 314.0 | 1955 | ||
| 238. | Dwight Gooden | 250 | 207.0 | 1988 | |
| Frank Baumann | 250 | 278.0 | 1962 | ||
| Ramon Monzant | 250 | 306.0 | 1960 | ||
| Moe Drabowsky | 250 | 290.0 | 1959 | ||
| Johnny Vander Meer | 250 | 312.7 | 1945 | ||
| Pat Malone | 250 | 306.7 | 1939 | ||
| 244. | Masanori Murakami | 249 | 235.7 | 1971 | |
| Ike Delock | 249 | 367.3 | 1965 | ||
| Juan Marichal * | 249 | 358.3 | 1965 | ||
| Dick Lemay | 249 | 268.0 | 1965 | ||
| Johnny Antonelli | 249 | 316.7 | 1963 | ||
| Joey Jay | 249 | 331.0 | 1958 | ||
| 250. | Rollie Fingers | 248 | 280.3 | 1972 | |
| Jim Maloney | 248 | 289.0 | 1967 | ||
| Dick Lemay | 248 | 250.0 | 1966 | ||
| Joey Jay | 248 | 331.0 | 1962 | ||
| Johnny Antonelli | 248 | 323.3 | 1954 | ||
| 255. | Don Demola | 247 | 285.0 | 1984 | |
| Jim Derrington | 247 | 251.3 | 1969 | ||
| Gus Keriazakos | 247 | 253.7 | 1968 | ||
| 258. | Randy Johnson | 246 | 241.0 | 1989 | |
| Balor Moore | 246 | 267.0 | 1980 | ||
| Gene Conley * | 246 | 302.7 | 1964 | ||
| Charlie Beamon | 246 | 279.7 | 1962 | ||
| Sandy Koufax * | 246 | 276.7 | 1957 | ||
| Kent Peterson | 246 | 263.3 | 1957 | ||
| Sandy Koufax * | 246 | 275.0 | 1956 | ||
| 265. | Jim Brewer * | 245 | 222.7 | 1973 | |
| Joe Horlen | 245 | 326.7 | 1968 | ||
| Billy Hoeft | 245 | 325.7 | 1967 | ||
| Bill Singer | 245 | 357.7 | 1966 | ||
| Gus Keriazakos | 245 | 255.3 | 1958 | ||
| Don Newcombe | 245 | 325.0 | 1953 | ||
| Johnny Vander Meer | 245 | 305.3 | 1947 | ||
| Johnny Vander Meer | 245 | 338.0 | 1940 | ||
| 273. | Billy Hoeft | 244 | 363.0 | 1963 | |
| Moe Drabowsky | 244 | 287.3 | 1962 | ||
| Don Newcombe | 244 | 299.7 | 1957 | ||
| 276. | Bart Johnson | 243 | 247.3 | 1984 | |
| Tug McGraw | 243 | 313.7 | 1968 | ||
| Frank Baumann | 243 | 300.0 | 1965 | ||
| Gene Conley * | 243 | 307.3 | 1957 | ||
| Pat Malone | 243 | 336.7 | 1931 | ||
| 281. | Balor Moore | 242 | 262.7 | 1985 | |
| Larry Sherry | 242 | 313.0 | 1962 | ||
| Ike Delock | 242 | 315.3 | 1959 | ||
| Dean Stone | 242 | 309.3 | 1957 | ||
| 285. | Don Sutton | 241 | 259.3 | 1977 | |
| Nolan Ryan | 241 | 217.0 | 1973 | ||
| George Brunet | 241 | 271.3 | 1969 | ||
| Don Drysdale | 241 | 255.0 | 1967 | ||
| Dean Stone | 241 | 291.0 | 1960 | ||
| Billy Hoeft | 241 | 303.0 | 1959 | ||
| 291. | Mark Langston | 240 | 251.0 | 1986 | |
| Don Demola | 240 | 276.0 | 1985 | ||
| Don Drysdale | 240 | 290.7 | 1969 | ||
| Juan Marichal * | 240 | 362.7 | 1964 | ||
| Don Newcombe | 240 | 252.3 | 1960 | ||
| Ted Gray | 240 | 278.0 | 1952 | ||
| 297. | Roger Clemens | 239 | 240.7 | 1990 | |
| Tom Qualters | 239 | 277.3 | 1968 | ||
| Ted Gray | 239 | 233.3 | 1956 | ||
| 300. | Randy Johnson | 238 | 242.7 | 1988 |
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