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| Single-Season ERA Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | ERA | IP | Year | Career Leaderboard |
| 1. | John Hiller | 1.431 | 245.3 | 1975 | |
| 2. | Juan Marichal * | 1.449 | 254.7 | 1971 | |
| 3. | John Hiller | 1.575 | 205.7 | 1972 | |
| 4. | Chuck Stobbs * | 1.663 | 368.0 | 1960 | |
| 5. | Chuck Stobbs * | 1.784 | 333.0 | 1955 | |
| 6. | John Hiller | 1.798 | 240.3 | 1973 | |
| 7. | Gene Conley * | 1.800 | 335.0 | 1959 | |
| 8. | Chuck Stobbs * | 1.908 | 349.0 | 1953 | |
| 9. | John Denny | 1.926 | 238.3 | 1983 | |
| 10. | Dwight Gooden | 1.972 | 237.3 | 1989 | |
| 11. | Gene Conley * | 1.992 | 334.3 | 1963 | |
| 12. | Gene Conley * | 2.008 | 349.7 | 1961 | |
| 13. | Tom Qualters | 2.022 | 267.0 | 1963 | |
| 14. | Tom Qualters | 2.027 | 279.7 | 1966 | |
| 15. | Rich Bordi | 2.032 | 243.7 | 1984 | |
| 16. | Warren Spahn * | 2.032 | 367.7 | 1956 | |
| 17. | Juan Marichal * | 2.034 | 358.3 | 1965 | |
| 18. | Kent Peterson | 2.048 | 263.7 | 1960 | |
| 19. | Tom Qualters | 2.049 | 294.3 | 1961 | |
| 20. | Warren Spahn * | 2.056 | 367.7 | 1949 | |
| 21. | John Gelnar | 2.057 | 275.7 | 1971 | |
| 22. | Warren Spahn * | 2.065 | 348.7 | 1955 | |
| 23. | Warren Spahn * | 2.068 | 378.7 | 1953 | |
| 24. | Jim Brewer * | 2.072 | 299.7 | 1967 | |
| 25. | Hal Reniff | 2.077 | 212.3 | 1968 | |
| 26. | Lance Rautzhan | 2.077 | 255.7 | 1982 | |
| 27. | Juan Marichal * | 2.097 | 386.3 | 1968 | |
| 28. | Gene Conley * | 2.108 | 307.3 | 1957 | |
| 29. | Sandy Koufax * | 2.109 | 281.7 | 1959 | |
| 30. | Rich Bordi | 2.117 | 242.3 | 1989 | |
| 31. | Rollie Sheldon | 2.130 | 342.3 | 1968 | |
| 32. | Don Demola | 2.135 | 240.3 | 1989 | |
| 33. | Gene Conley * | 2.147 | 343.7 | 1962 | |
| 34. | Tom Seaver | 2.154 | 280.0 | 1971 | |
| 35. | Warren Spahn * | 2.162 | 374.7 | 1951 | |
| 36. | Lance Rautzhan | 2.177 | 186.0 | 1986 | |
| 37. | Gerry Arrigo | 2.180 | 181.7 | 1965 | |
| 38. | Chuck Stobbs * | 2.182 | 375.3 | 1961 | |
| 39. | Rich Bordi | 2.187 | 238.7 | 1983 | |
| 40. | Bob Miller | 2.190 | 312.3 | 1955 | |
| 41. | Ken Dayley | 2.196 | 250.0 | 1986 | |
| 42. | Bill Slayback | 2.202 | 294.3 | 1981 | |
| 43. | Rollie Fingers | 2.225 | 178.0 | 1971 | |
| 44. | Tom Qualters | 2.230 | 294.7 | 1962 | |
| 45. | Charlie Beamon | 2.231 | 310.7 | 1965 | |
| 46. | Randy Johnson | 2.231 | 238.0 | 1990 | |
| 47. | Juan Marichal * | 2.240 | 225.0 | 1970 | |
| 48. | Hal Reniff | 2.245 | 272.7 | 1966 | |
| 49. | John Gelnar | 2.247 | 268.3 | 1967 | |
| 50. | Bob Lacey | 2.250 | 164.0 | 1981 | |
| 51. | Rich Bordi | 2.253 | 259.7 | 1988 | |
| 52. | J.R. Richard * | 2.253 | 251.7 | 1984 | |
| 53. | Tom Qualters | 2.254 | 203.7 | 1969 | |
| 54. | Juan Marichal * | 2.260 | 378.3 | 1963 | |
| 55. | Gene Conley * | 2.264 | 314.0 | 1955 | |
| 56. | Luis Deleon | 2.267 | 258.0 | 1984 | |
| 57. | Sandy Koufax * | 2.270 | 297.3 | 1960 | |
| 58. | John Hiller | 2.270 | 222.0 | 1970 | |
| 59. | Mike Garman | 2.275 | 241.3 | 1983 | |
| 60. | Dean Chance | 2.277 | 355.7 | 1968 | |
| 61. | Seth Morehead | 2.279 | 312.0 | 1961 | |
| 62. | Gus Keriazakos | 2.281 | 319.7 | 1961 | |
| 63. | Jim O'Toole | 2.282 | 351.0 | 1965 | |
| 64. | Dean Stone | 2.299 | 309.3 | 1957 | |
| 65. | Charlie Beamon | 2.299 | 293.7 | 1964 | |
| 66. | Bruce Hurst | 2.302 | 230.7 | 1989 | |
| 67. | Jim Brewer * | 2.303 | 281.3 | 1966 | |
| 68. | Chuck Stobbs * | 2.304 | 332.0 | 1951 | |
| 69. | Jim Kaat | 2.306 | 269.3 | 1966 | |
| 70. | Lance Rautzhan | 2.307 | 249.7 | 1985 | |
| 71. | Jack McDowell | 2.309 | 269.0 | 1989 | |
| 72. | Duane Ward | 2.316 | 171.0 | 1987 | |
| 73. | Sandy Koufax * | 2.321 | 325.7 | 1964 | |
| 74. | Juan Marichal * | 2.323 | 379.7 | 1967 | |
| 75. | Mike Norris | 2.345 | 299.3 | 1984 | |
| 76. | Warren Spahn * | 2.349 | 379.3 | 1957 | |
| 77. | Juan Marichal * | 2.353 | 363.3 | 1966 | |
| 78. | Warren Spahn * | 2.355 | 378.3 | 1948 | |
| 79. | Eduardo Rodriguez | 2.360 | 267.0 | 1982 | |
| 80. | Milt Wilcox | 2.371 | 224.0 | 1981 | |
| 81. | Jim O'Toole | 2.378 | 340.7 | 1962 | |
| 82. | John Hiller | 2.378 | 234.7 | 1976 | |
| 83. | Steve Carlton * | 2.381 | 279.7 | 1979 | |
| 84. | Humberto Robinson | 2.384 | 313.3 | 1960 | |
| 85. | Chuck Stobbs * | 2.384 | 290.7 | 1954 | |
| 86. | Stu Miller | 2.390 | 305.0 | 1956 | |
| 87. | Jim Brewer * | 2.392 | 286.0 | 1968 | |
| 88. | Greg Minton | 2.393 | 240.7 | 1980 | |
| 89. | Juan Marichal * | 2.398 | 274.0 | 1972 | |
| 90. | Tom Qualters | 2.398 | 289.0 | 1964 | |
| 91. | Willie Hernandez | 2.400 | 225.0 | 1988 | |
| 92. | Tom Qualters | 2.401 | 292.3 | 1967 | |
| 93. | Humberto Robinson | 2.405 | 314.3 | 1961 | |
| 94. | Chuck Stobbs * | 2.409 | 340.0 | 1964 | |
| 95. | Don Demola | 2.411 | 265.0 | 1980 | |
| 96. | Juan Marichal * | 2.411 | 227.7 | 1973 | |
| 97. | Chuck Stobbs * | 2.412 | 362.0 | 1965 | |
| 98. | Tom Seaver | 2.413 | 272.3 | 1970 | |
| 99. | Chuck Stobbs * | 2.413 | 313.3 | 1956 | |
| 100. | Dean Stone | 2.413 | 294.7 | 1958 | |
| 101. | Warren Spahn * | 2.415 | 369.0 | 1950 | |
| 102. | Dick Hall | 2.419 | 253.0 | 1964 | |
| 103. | Bill Butler | 2.420 | 238.0 | 1977 | |
| 104. | Joey McLaughlin | 2.421 | 245.3 | 1984 | |
| 105. | Hal Reniff | 2.423 | 204.3 | 1965 | |
| 106. | Chuck Stobbs * | 2.423 | 308.3 | 1959 | |
| 107. | Rich Bordi | 2.424 | 241.3 | 1987 | |
| 108. | Sandy Koufax * | 2.426 | 337.7 | 1962 | |
| 109. | Warren Spahn * | 2.426 | 371.0 | 1952 | |
| 110. | Chuck Stobbs * | 2.432 | 355.3 | 1962 | |
| 111. | Sandy Koufax * | 2.432 | 296.0 | 1961 | |
| 112. | Virgil Jester | 2.434 | 277.3 | 1960 | |
| 113. | Rollie Fingers | 2.436 | 266.0 | 1969 | |
| 114. | Kevin Gross | 2.439 | 254.7 | 1990 | |
| 115. | Herb Score | 2.439 | 324.7 | 1963 | |
| 116. | Jack Morris | 2.440 | 284.0 | 1981 | |
| 117. | Earl Johnson * | 2.445 | 327.7 | 1946 | |
| 118. | Greg Minton | 2.451 | 216.7 | 1982 | |
| 119. | Billy Hoeft | 2.452 | 345.0 | 1964 | |
| 120. | Chuck Stobbs * | 2.455 | 359.3 | 1957 | |
| 121. | Gene Conley * | 2.455 | 337.3 | 1960 | |
| 122. | John Hiller | 2.455 | 194.3 | 1969 | |
| 123. | Ramon Monzant | 2.455 | 300.7 | 1961 | |
| 124. | Gene Conley * | 2.457 | 285.7 | 1954 | |
| 125. | Steve Hamilton | 2.461 | 245.0 | 1964 | |
| 126. | Gary Nolan * | 2.462 | 223.0 | 1985 | |
| 127. | Milt Wilcox | 2.464 | 175.3 | 1983 | |
| 128. | Balor Moore | 2.467 | 262.7 | 1985 | |
| 129. | Ike Delock | 2.467 | 324.7 | 1963 | |
| 130. | Rick Jones | 2.467 | 193.3 | 1984 | |
| 131. | Joey McLaughlin | 2.469 | 226.0 | 1985 | |
| 132. | Lance McCullers | 2.469 | 167.7 | 1986 | |
| 133. | Mike Garman | 2.470 | 211.3 | 1982 | |
| 134. | Steve Carlton * | 2.472 | 284.0 | 1976 | |
| 135. | John Gelnar | 2.473 | 222.0 | 1970 | |
| 136. | Chuck Stobbs * | 2.475 | 363.7 | 1958 | |
| 137. | Rich Bordi | 2.477 | 214.3 | 1990 | |
| 138. | Willie Hernandez | 2.479 | 203.3 | 1987 | |
| 139. | Billy Hoeft | 2.479 | 363.0 | 1963 | |
| 140. | Balor Moore | 2.492 | 216.7 | 1986 | |
| 141. | John Hiller | 2.496 | 238.0 | 1974 | |
| 142. | Pedro Borbon | 2.501 | 244.7 | 1973 | |
| 143. | Chuck Stobbs * | 2.502 | 331.0 | 1950 | |
| 144. | Jim Brewer * | 2.502 | 223.0 | 1975 | |
| 145. | Gus Keriazakos | 2.505 | 294.7 | 1965 | |
| 146. | Herb Score | 2.508 | 262.0 | 1960 | |
| 147. | Harry Brecheen | 2.508 | 258.3 | 1946 | |
| 148. | Bob Rush | 2.516 | 293.3 | 1953 | |
| 149. | Joe Moeller * | 2.522 | 278.3 | 1976 | |
| 150. | Joey McLaughlin | 2.527 | 213.7 | 1989 | |
| 151. | Gary Nolan * | 2.531 | 288.0 | 1981 | |
| Jim Brewer * | 2.531 | 256.0 | 1965 | ||
| 153. | George Brunet | 2.531 | 245.3 | 1965 | |
| 154. | Rollie Sheldon | 2.535 | 326.7 | 1966 | |
| 155. | Rollie Fingers | 2.536 | 262.7 | 1970 | |
| 156. | Jim Beattie | 2.536 | 191.7 | 1980 | |
| 157. | George Brunet | 2.536 | 301.7 | 1966 | |
| 158. | Joe Bonikowski | 2.538 | 305.0 | 1964 | |
| 159. | Dean Chance | 2.546 | 332.3 | 1962 | |
| 160. | Lance Rautzhan | 2.546 | 240.3 | 1980 | |
| 161. | Andy Rincon | 2.549 | 190.7 | 1984 | |
| 162. | Joe Moeller * | 2.552 | 310.3 | 1970 | |
| 163. | Steve Hamilton | 2.553 | 282.0 | 1965 | |
| 164. | Gene Conley * | 2.555 | 253.7 | 1956 | |
| 165. | Carl Willis | 2.563 | 196.7 | 1987 | |
| 166. | Mike Torrez | 2.563 | 263.3 | 1979 | |
| 167. | Jerry Reuss | 2.564 | 284.3 | 1981 | |
| 168. | Charlie Leibrandt | 2.568 | 231.3 | 1988 | |
| 169. | George Brunet | 2.570 | 304.7 | 1963 | |
| 170. | John Gelnar | 2.571 | 273.0 | 1969 | |
| 171. | Tom Seaver | 2.573 | 283.3 | 1967 | |
| 172. | Rollie Sheldon | 2.573 | 269.3 | 1970 | |
| 173. | Lance Rautzhan | 2.578 | 192.0 | 1987 | |
| 174. | Jack Salveson | 2.579 | 268.7 | 1946 | |
| 175. | Bill Landis | 2.581 | 279.0 | 1967 | |
| 176. | Joe Presko | 2.583 | 292.7 | 1962 | |
| 177. | Marshall Bridges | 2.585 | 163.7 | 1961 | |
| 178. | Bob Rush | 2.586 | 362.0 | 1951 | |
| 179. | Rick Reuschel | 2.591 | 264.0 | 1978 | |
| 180. | Randy Johnson | 2.596 | 242.7 | 1988 | |
| 181. | Mark Eichhorn | 2.598 | 263.3 | 1982 | |
| 182. | Mike McQueen | 2.598 | 246.0 | 1979 | |
| 183. | Earl Johnson * | 2.598 | 301.3 | 1947 | |
| 184. | George Brunet | 2.604 | 280.0 | 1961 | |
| 185. | Don Sutton | 2.604 | 169.3 | 1981 | |
| 186. | Bob Miller | 2.605 | 283.3 | 1958 | |
| 187. | Red Swanson | 2.607 | 310.7 | 1966 | |
| 188. | Dwight Gooden | 2.609 | 207.0 | 1988 | |
| 189. | Gene Conley * | 2.617 | 302.7 | 1964 | |
| 190. | Bob Veale | 2.618 | 285.3 | 1966 | |
| 191. | Rick Reuschel | 2.618 | 264.7 | 1977 | |
| 192. | Lance McCullers | 2.621 | 182.0 | 1988 | |
| 193. | Rick Reuschel | 2.621 | 274.7 | 1975 | |
| 194. | George Brunet | 2.629 | 328.7 | 1968 | |
| 195. | Joe Moeller * | 2.631 | 311.3 | 1971 | |
| 196. | Joe Hoerner | 2.631 | 236.0 | 1965 | |
| 197. | John Denny | 2.633 | 294.0 | 1977 | |
| 198. | Gary Peters | 2.636 | 293.7 | 1966 | |
| 199. | J.R. Richard * | 2.638 | 259.3 | 1979 | |
| 200. | Jim Brewer * | 2.639 | 191.0 | 1971 | |
| 201. | Scott Sanderson | 2.645 | 245.0 | 1981 | |
| 202. | Warren Spahn * | 2.659 | 375.7 | 1947 | |
| 203. | Denny Lemaster | 2.661 | 162.3 | 1969 | |
| 204. | Nino Espinosa | 2.664 | 246.7 | 1986 | |
| 205. | Stu Miller | 2.668 | 280.0 | 1958 | |
| 206. | George Winn | 2.668 | 364.3 | 1930 | |
| 207. | Chuck Stobbs * | 2.670 | 269.7 | 1963 | |
| 208. | Mark Eichhorn | 2.672 | 195.3 | 1984 | |
| 209. | Newt Kimball | 2.681 | 231.7 | 1939 | |
| 210. | Don Nottebart | 2.681 | 285.3 | 1967 | |
| 211. | Milt Wilcox | 2.682 | 295.3 | 1977 | |
| 212. | Joe Horlen | 2.684 | 328.7 | 1967 | |
| 213. | John Denny | 2.684 | 288.3 | 1982 | |
| 214. | Scott Sanderson | 2.686 | 258.0 | 1982 | |
| 215. | Bobby Witt | 2.688 | 227.7 | 1988 | |
| 216. | Steve Hamilton | 2.690 | 261.0 | 1966 | |
| 217. | Ken Dayley | 2.692 | 224.0 | 1989 | |
| 218. | Bob Veale | 2.693 | 270.7 | 1968 | |
| 219. | Frank Baumann | 2.693 | 274.0 | 1964 | |
| 220. | Bill Slayback | 2.700 | 260.0 | 1982 | |
| 221. | Vic Aldridge | 2.702 | 373.0 | 1930 | |
| 222. | Joe Presko | 2.703 | 326.3 | 1961 | |
| 223. | Andy Rincon | 2.703 | 266.3 | 1985 | |
| 224. | Gene Conley * | 2.708 | 342.3 | 1958 | |
| 225. | Billy Hoeft | 2.710 | 285.7 | 1961 | |
| 226. | Bob Miller | 2.712 | 235.7 | 1960 | |
| 227. | Rick Reuschel | 2.712 | 232.3 | 1981 | |
| 228. | Bob Miller | 2.712 | 292.0 | 1959 | |
| 229. | Johnny Vander Meer | 2.716 | 338.0 | 1940 | |
| 230. | John Gelnar | 2.717 | 311.3 | 1968 | |
| 231. | Rick Reuschel | 2.717 | 258.3 | 1979 | |
| 232. | Billy Hoeft | 2.718 | 354.3 | 1966 | |
| 233. | Danny McDevitt | 2.721 | 304.3 | 1962 | |
| 234. | Tom Qualters | 2.723 | 277.7 | 1965 | |
| 235. | Billy Hoeft | 2.728 | 290.3 | 1968 | |
| 236. | Dick Baney | 2.730 | 244.0 | 1980 | |
| 237. | Gary Peters | 2.732 | 168.0 | 1963 | |
| 238. | Lance Rautzhan | 2.732 | 194.3 | 1989 | |
| 239. | Dizzy Dean * | 2.734 | 375.3 | 1931 | |
| 240. | Frank Tanana | 2.737 | 217.0 | 1984 | |
| 241. | Elias Sosa | 2.742 | 170.7 | 1980 | |
| 242. | Dave Boswell | 2.744 | 265.7 | 1968 | |
| 243. | Jim Brewer * | 2.745 | 219.7 | 1969 | |
| 244. | Gerry Arrigo | 2.746 | 196.7 | 1963 | |
| 245. | Garland Buckeye | 2.746 | 311.3 | 1930 | |
| 246. | Chuck Stobbs * | 2.747 | 324.3 | 1967 | |
| 247. | Ralph Terry | 2.747 | 285.0 | 1967 | |
| 248. | Joe Sambito | 2.748 | 226.0 | 1985 | |
| 249. | Julio Solano | 2.750 | 163.7 | 1987 | |
| 250. | Earl Johnson * | 2.753 | 320.3 | 1952 | |
| 251. | Ramon Hernandez | 2.754 | 166.7 | 1974 | |
| 252. | Luis Tiant | 2.755 | 362.7 | 1968 | |
| 253. | Don Drysdale | 2.756 | 290.7 | 1969 | |
| 254. | John Denny | 2.758 | 297.0 | 1981 | |
| 255. | Paul Dean * | 2.760 | 358.7 | 1937 | |
| 256. | Billy Hoeft | 2.761 | 280.3 | 1960 | |
| 257. | Jim Brewer * | 2.762 | 277.0 | 1964 | |
| 258. | Don Demola | 2.765 | 250.7 | 1982 | |
| 259. | Warren Spahn * | 2.765 | 276.7 | 1959 | |
| 260. | Joe Beckwith | 2.766 | 218.0 | 1983 | |
| 261. | Dick Ruthven | 2.767 | 257.0 | 1981 | |
| 262. | Kent Peterson | 2.769 | 328.3 | 1961 | |
| 263. | Larry Sherry | 2.769 | 234.0 | 1965 | |
| 264. | Jackie Collum | 2.770 | 204.7 | 1957 | |
| 265. | Alan Foster | 2.771 | 240.3 | 1981 | |
| 266. | Ken Sanders | 2.774 | 194.7 | 1970 | |
| 267. | John Smiley | 2.780 | 268.7 | 1988 | |
| 268. | Eduardo Rodriguez | 2.782 | 297.7 | 1986 | |
| 269. | Bob Miller | 2.782 | 317.0 | 1956 | |
| 270. | John Denny | 2.783 | 216.7 | 1988 | |
| 271. | Joey McLaughlin | 2.784 | 245.7 | 1986 | |
| 272. | Dave Boswell | 2.786 | 168.0 | 1977 | |
| 273. | Bud Daley | 2.788 | 297.0 | 1965 | |
| 274. | Cliff Melton * | 2.789 | 284.0 | 1937 | |
| 275. | Bob Veale | 2.789 | 251.7 | 1964 | |
| 276. | Billy Hoeft | 2.790 | 351.7 | 1962 | |
| 277. | Ken Dayley | 2.790 | 209.7 | 1987 | |
| 278. | Dennis Eckersley | 2.792 | 274.0 | 1980 | |
| 279. | Juan Marichal * | 2.792 | 293.3 | 1969 | |
| 280. | Rollie Fingers | 2.793 | 280.3 | 1972 | |
| 281. | Johnny Antonelli | 2.794 | 325.3 | 1959 | |
| 282. | Earl Johnson * | 2.795 | 312.3 | 1944 | |
| 283. | Jim Kaat | 2.799 | 318.3 | 1962 | |
| 284. | Bill Landis | 2.799 | 209.0 | 1975 | |
| 285. | John Denny | 2.799 | 244.3 | 1987 | |
| 286. | Ron Perranoski | 2.800 | 189.7 | 1969 | |
| 287. | Charlie Beamon | 2.800 | 279.7 | 1962 | |
| 288. | George Lauzerique | 2.800 | 215.3 | 1977 | |
| 289. | Gary Peters | 2.802 | 318.0 | 1965 | |
| 290. | Mike Marshall | 2.802 | 273.0 | 1974 | |
| 291. | George Brunet | 2.803 | 263.3 | 1960 | |
| 292. | Danny McDevitt | 2.803 | 289.0 | 1966 | |
| 293. | Steve Carlton * | 2.804 | 276.0 | 1983 | |
| 294. | Al Jackson | 2.805 | 205.3 | 1966 | |
| 295. | Mike Garman | 2.808 | 234.0 | 1981 | |
| 296. | George Brunet | 2.809 | 240.3 | 1970 | |
| 297. | Mel Parnell | 2.809 | 272.3 | 1948 | |
| 298. | Woodie Fryman | 2.812 | 169.7 | 1966 | |
| 299. | Masanori Murakami | 2.813 | 288.0 | 1966 | |
| 300. | Bill Lee | 2.813 | 246.3 | 1981 |
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