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| Third Basemen Single-Season Runs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Runs | PA | Year | Career Leaderboard |
| 1. | Eddie Mathews | 139 | 652 | 1955 | |
| 2. | Mel Ott * | 135 | 684 | 1944 | |
| 3. | Snuffy Stirnweiss | 133 | 715 | 1951 | |
| 4. | Sid Gordon | 130 | 700 | 1948 | |
| Arky Vaughan * | 130 | 676 | 1938 | ||
| 6. | Bill Serena | 129 | 699 | 1953 | |
| 7. | Arky Vaughan * | 126 | 680 | 1945 | |
| Mel Ott * | 126 | 642 | 1936 | ||
| 9. | Arky Vaughan * | 125 | 683 | 1939 | |
| 10. | Harmon Killebrew * | 123 | 665 | 1961 | |
| 11. | Harmon Killebrew * | 122 | 631 | 1966 | |
| 12. | Gary Sheffield | 121 | 663 | 1990 | |
| 13. | John Milner | 120 | 683 | 1981 | |
| Mike Schmidt | 120 | 689 | 1975 | ||
| Billy Williams | 120 | 709 | 1972 | ||
| Willie Kamm | 120 | 690 | 1930 | ||
| 17. | Whitey Kurowski | 119 | 682 | 1950 | |
| Jackie Robinson | 119 | 692 | 1949 | ||
| Ellis Clary | 119 | 650 | 1949 | ||
| Arky Vaughan * | 119 | 657 | 1943 | ||
| Pie Traynor | 119 | 701 | 1935 | ||
| 22. | Bill Serena | 118 | 667 | 1954 | |
| Arky Vaughan * | 118 | 674 | 1944 | ||
| 24. | Mike Schmidt | 117 | 698 | 1979 | |
| Bill Serena | 117 | 676 | 1951 | ||
| Whitey Kurowski | 117 | 691 | 1948 | ||
| Mel Ott * | 117 | 604 | 1931 | ||
| 28. | Bob Bailey | 116 | 666 | 1965 | |
| Bill Serena | 116 | 681 | 1957 | ||
| Bill Serena | 116 | 585 | 1952 | ||
| Arky Vaughan * | 116 | 685 | 1936 | ||
| 32. | Harmon Killebrew * | 115 | 671 | 1968 | |
| Snuffy Stirnweiss | 115 | 731 | 1947 | ||
| 34. | Fred Haney | 114 | 702 | 1930 | |
| 35. | Bobby Thomson | 113 | 662 | 1952 | |
| Jackie Robinson | 113 | 687 | 1947 | ||
| 37. | Mike Schmidt | 112 | 660 | 1976 | |
| Harmon Killebrew * | 112 | 636 | 1967 | ||
| Harmon Killebrew * | 112 | 636 | 1960 | ||
| Eddie Mathews | 112 | 669 | 1954 | ||
| Arky Vaughan * | 112 | 646 | 1942 | ||
| Arky Vaughan * | 112 | 668 | 1941 | ||
| Mel Ott * | 112 | 663 | 1941 | ||
| Arky Vaughan * | 112 | 677 | 1937 | ||
| 45. | Billy Williams | 111 | 698 | 1973 | |
| Bob Bailey | 111 | 684 | 1973 | ||
| Whitey Kurowski | 111 | 688 | 1951 | ||
| 48. | Bob Bailey | 110 | 646 | 1974 | |
| Bob Bailey | 110 | 665 | 1972 | ||
| Adolfo Phillips | 110 | 640 | 1971 | ||
| Bob Bailey | 110 | 681 | 1970 | ||
| Harmon Killebrew * | 110 | 681 | 1963 | ||
| Whitey Kurowski | 110 | 677 | 1949 | ||
| Arky Vaughan * | 110 | 653 | 1935 | ||
| 55. | Al Rosen | 109 | 626 | 1949 | |
| Jackie Robinson | 109 | 682 | 1948 | ||
| Sid Gordon | 109 | 669 | 1947 | ||
| Jackie Robinson | 109 | 700 | 1946 | ||
| 59. | Gary Sheffield | 108 | 657 | 1989 | |
| George Scott | 108 | 680 | 1976 | ||
| John Milner | 108 | 679 | 1975 | ||
| Billy Williams | 108 | 656 | 1971 | ||
| Harmon Killebrew * | 108 | 652 | 1965 | ||
| Eddie Mathews | 108 | 662 | 1961 | ||
| Mel Ott * | 108 | 677 | 1942 | ||
| Arky Vaughan * | 108 | 668 | 1940 | ||
| 67. | George Brett | 107 | 691 | 1987 | |
| George Scott | 107 | 661 | 1972 | ||
| Mel Ott * | 107 | 671 | 1945 | ||
| Mel Ott * | 107 | 643 | 1943 | ||
| 71. | Bob Horner | 106 | 670 | 1987 | |
| Harmon Killebrew * | 106 | 665 | 1969 | ||
| Eddie Mathews | 106 | 673 | 1967 | ||
| Jim Fregosi | 106 | 663 | 1966 | ||
| Bill Serena | 106 | 675 | 1955 | ||
| 76. | Bill Serena | 105 | 680 | 1950 | |
| Jackie Robinson | 105 | 679 | 1950 | ||
| 78. | Tom O'Malley | 104 | 682 | 1987 | |
| Larry Parrish | 104 | 639 | 1979 | ||
| George Scott | 104 | 665 | 1973 | ||
| Pete Ward | 104 | 630 | 1966 | ||
| Eddie Mathews | 104 | 661 | 1960 | ||
| 83. | George Brett | 103 | 687 | 1988 | |
| Sal Bando | 103 | 641 | 1978 | ||
| Harmon Killebrew * | 103 | 673 | 1971 | ||
| Tony Perez | 103 | 672 | 1970 | ||
| Harmon Killebrew * | 103 | 651 | 1962 | ||
| Bobby Thomson | 103 | 636 | 1953 | ||
| Whitey Kurowski | 103 | 648 | 1944 | ||
| Mel Ott * | 103 | 641 | 1940 | ||
| Willie Kamm | 103 | 677 | 1931 | ||
| 92. | George Brett | 102 | 643 | 1984 | |
| John Milner | 102 | 670 | 1978 | ||
| Mike Schmidt | 102 | 671 | 1977 | ||
| Bob Bailey | 102 | 658 | 1971 | ||
| Bob Bailey | 102 | 667 | 1966 | ||
| Snuffy Stirnweiss | 102 | 683 | 1950 | ||
| Johnny Pesky | 102 | 658 | 1950 | ||
| Mel Ott * | 102 | 688 | 1946 | ||
| Arky Vaughan * | 102 | 660 | 1946 | ||
| Sid Gordon | 102 | 665 | 1944 | ||
| Mel Ott * | 102 | 650 | 1930 | ||
| 103. | Denny Walling | 101 | 672 | 1982 | |
| Lew Riggs | 101 | 664 | 1936 | ||
| Mel Ott * | 101 | 632 | 1934 | ||
| Randy Moore | 101 | 683 | 1933 | ||
| 107. | Fred McGriff | 100 | 664 | 1988 | |
| John Milner | 100 | 639 | 1983 | ||
| Bill Madlock | 100 | 638 | 1979 | ||
| Bill Serena | 100 | 668 | 1956 | ||
| Ralph Hodgin | 100 | 660 | 1948 | ||
| Whitey Kurowski | 100 | 601 | 1946 | ||
| Sid Gordon | 100 | 636 | 1943 | ||
| Mel Ott * | 100 | 609 | 1935 | ||
| Willie Kamm | 100 | 583 | 1932 | ||
| 116. | Gary Sheffield | 99 | 601 | 1988 | |
| Bob Horner | 99 | 662 | 1980 | ||
| Tony Perez | 99 | 608 | 1971 | ||
| Eddie Mathews | 99 | 633 | 1958 | ||
| Jim Finigan | 99 | 685 | 1956 | ||
| Snuffy Stirnweiss | 99 | 659 | 1952 | ||
| Al Rosen | 99 | 560 | 1948 | ||
| 123. | Harmon Killebrew * | 98 | 654 | 1970 | |
| George Scott | 98 | 613 | 1970 | ||
| Tony Perez | 98 | 646 | 1969 | ||
| Harlond Clift | 98 | 709 | 1935 | ||
| 127. | George Brett | 97 | 651 | 1985 | |
| Oscar Gamble | 97 | 688 | 1982 | ||
| George Scott | 97 | 657 | 1978 | ||
| John Milner | 97 | 625 | 1974 | ||
| Jim Ray Hart | 97 | 676 | 1973 | ||
| John Milner | 97 | 634 | 1973 | ||
| Bobby Thomson | 97 | 634 | 1955 | ||
| Al Rosen | 97 | 601 | 1950 | ||
| Arky Vaughan * | 97 | 540 | 1934 | ||
| 136. | Bob Horner | 96 | 635 | 1983 | |
| Mike Schmidt | 96 | 674 | 1980 | ||
| Oscar Gamble | 96 | 607 | 1978 | ||
| Sal Bando | 96 | 666 | 1975 | ||
| Bob Bailey | 96 | 647 | 1975 | ||
| Tony Perez | 96 | 639 | 1973 | ||
| Jim Fregosi | 96 | 601 | 1970 | ||
| Tony Perez | 96 | 634 | 1968 | ||
| Eddie Mathews | 96 | 636 | 1957 | ||
| Bobby Thomson | 96 | 640 | 1954 | ||
| Sid Gordon | 96 | 680 | 1945 | ||
| 147. | Ken Caminiti | 95 | 581 | 1990 | |
| Mike Schmidt | 95 | 655 | 1974 | ||
| Bud Harrelson | 95 | 554 | 1974 | ||
| Jim Ray Hart | 95 | 677 | 1971 | ||
| Dick Howser | 95 | 705 | 1967 | ||
| Billy Williams | 95 | 628 | 1963 | ||
| Luis Olmo | 95 | 654 | 1954 | ||
| Frankie Zak | 95 | 657 | 1950 | ||
| Sid Gordon | 95 | 631 | 1950 | ||
| Ken Keltner | 95 | 665 | 1944 | ||
| Red Rolfe | 95 | 667 | 1939 | ||
| 158. | George Brett | 94 | 639 | 1983 | |
| Bill Madlock | 94 | 662 | 1981 | ||
| Jim Ray Hart | 94 | 639 | 1970 | ||
| Dick Howser | 94 | 681 | 1966 | ||
| Billy Williams | 94 | 658 | 1964 | ||
| Randy Moore | 94 | 618 | 1936 | ||
| Lou Chiozza | 94 | 582 | 1936 | ||
| Mel Ott * | 94 | 626 | 1933 | ||
| 166. | Gerald Perry | 93 | 642 | 1988 | |
| George Brett | 93 | 667 | 1986 | ||
| Tony Perez | 93 | 628 | 1976 | ||
| George Brett | 93 | 607 | 1976 | ||
| Sal Bando | 93 | 670 | 1973 | ||
| Joe Foy | 93 | 658 | 1972 | ||
| Sal Bando | 93 | 640 | 1971 | ||
| George Scott | 93 | 618 | 1971 | ||
| Jim Ray Hart | 93 | 652 | 1969 | ||
| Billy Williams | 93 | 592 | 1960 | ||
| Bill Serena | 93 | 662 | 1959 | ||
| Whitey Kurowski | 93 | 645 | 1952 | ||
| Snuffy Stirnweiss | 93 | 638 | 1946 | ||
| Ken Keltner | 93 | 650 | 1938 | ||
| Ossie Bluege | 93 | 664 | 1931 | ||
| 181. | Kevin Mitchell | 92 | 635 | 1988 | |
| Larry Parrish | 92 | 641 | 1987 | ||
| Mike Schmidt | 92 | 626 | 1982 | ||
| John Milner | 92 | 605 | 1977 | ||
| Adolfo Phillips | 92 | 596 | 1974 | ||
| Eddie Mathews | 92 | 652 | 1962 | ||
| Sid Gordon | 92 | 684 | 1949 | ||
| 188. | Sal Bando | 91 | 643 | 1976 | |
| Jim Ray Hart | 91 | 638 | 1966 | ||
| Harmon Killebrew * | 91 | 656 | 1964 | ||
| Jim Finigan | 91 | 650 | 1957 | ||
| Whitey Kurowski | 91 | 654 | 1947 | ||
| Randy Moore | 91 | 640 | 1934 | ||
| Mel Ott * | 91 | 587 | 1932 | ||
| Pie Traynor | 91 | 669 | 1930 | ||
| 196. | George Brett | 90 | 657 | 1978 | |
| Bud Harrelson | 90 | 551 | 1978 | ||
| Billy Williams | 90 | 635 | 1965 | ||
| Sid Gordon | 90 | 662 | 1951 | ||
| Snuffy Stirnweiss | 90 | 674 | 1948 | ||
| Luis Olmo | 90 | 662 | 1946 | ||
| Woody English | 90 | 689 | 1937 | ||
| Mel Ott * | 90 | 611 | 1937 | ||
| Arky Vaughan * | 90 | 603 | 1932 | ||
| Frankie Frisch | 90 | 654 | 1931 | ||
| 206. | Gerald Perry | 89 | 685 | 1990 | |
| Oscar Gamble | 89 | 666 | 1983 | ||
| Larry Parrish | 89 | 647 | 1980 | ||
| Bob Bailey | 89 | 626 | 1976 | ||
| Eddie Mathews | 89 | 652 | 1956 | ||
| Jim Finigan | 89 | 653 | 1954 | ||
| Ellis Clary | 89 | 647 | 1950 | ||
| Pie Traynor | 89 | 662 | 1936 | ||
| Arky Vaughan * | 89 | 562 | 1933 | ||
| 215. | Ken Caminiti | 88 | 660 | 1989 | |
| Billy Williams | 88 | 628 | 1974 | ||
| Adolfo Phillips | 88 | 666 | 1972 | ||
| Dick Howser | 88 | 674 | 1969 | ||
| Billy Williams | 88 | 645 | 1969 | ||
| Mack Jones | 88 | 625 | 1966 | ||
| Dick Howser | 88 | 654 | 1962 | ||
| Bob Dillinger | 88 | 577 | 1952 | ||
| Joe Orengo | 88 | 676 | 1944 | ||
| Sid Gordon | 88 | 689 | 1942 | ||
| Lew Riggs | 88 | 671 | 1937 | ||
| Ossie Bluege | 88 | 642 | 1932 | ||
| Randy Moore | 88 | 519 | 1931 | ||
| 228. | Greg Walker | 87 | 638 | 1990 | |
| Bob Horner | 87 | 665 | 1988 | ||
| Gerald Perry | 87 | 637 | 1987 | ||
| Gerald Perry | 87 | 652 | 1986 | ||
| Denny Walling | 87 | 548 | 1986 | ||
| Larry Parrish | 87 | 615 | 1984 | ||
| Mike Schmidt | 87 | 681 | 1983 | ||
| Eric Soderholm | 87 | 614 | 1980 | ||
| John Milner | 87 | 644 | 1976 | ||
| Tony Perez | 87 | 645 | 1972 | ||
| Pete Ward | 87 | 617 | 1967 | ||
| Bill Serena | 87 | 690 | 1958 | ||
| Johnny Pesky | 87 | 555 | 1953 | ||
| Johnny Pesky | 87 | 620 | 1944 | ||
| Mel Ott * | 87 | 518 | 1939 | ||
| Mel Ott * | 87 | 640 | 1938 | ||
| 244. | Ken Caminiti | 86 | 655 | 1988 | |
| Joe Foy | 86 | 607 | 1975 | ||
| Bud Harrelson | 86 | 557 | 1975 | ||
| Steve Braun | 86 | 524 | 1975 | ||
| Jim Ray Hart | 86 | 664 | 1974 | ||
| Sal Bando | 86 | 657 | 1974 | ||
| Mike Schmidt | 86 | 646 | 1973 | ||
| Darrell Evans | 86 | 637 | 1973 | ||
| Jim Ray Hart | 86 | 643 | 1972 | ||
| George Scott | 86 | 669 | 1969 | ||
| Tony Perez | 86 | 641 | 1967 | ||
| Bob Bailey | 86 | 624 | 1964 | ||
| Jim Finigan | 86 | 653 | 1962 | ||
| Bobby Thomson | 86 | 641 | 1951 | ||
| Johnny Pesky | 86 | 634 | 1949 | ||
| Lee Handley | 86 | 594 | 1943 | ||
| Frankie Crosetti | 86 | 570 | 1936 | ||
| Fred Haney | 86 | 662 | 1931 | ||
| 262. | Greg Walker | 85 | 637 | 1989 | |
| Wade Boggs | 85 | 622 | 1989 | ||
| Alfredo Griffin | 85 | 588 | 1985 | ||
| George Brett | 85 | 647 | 1982 | ||
| Oscar Gamble | 85 | 664 | 1980 | ||
| George Brett | 85 | 633 | 1979 | ||
| Bill Madlock | 85 | 649 | 1976 | ||
| Adolfo Phillips | 85 | 643 | 1975 | ||
| Tony Perez | 85 | 628 | 1974 | ||
| George Scott | 85 | 600 | 1974 | ||
| Mike Shannon | 85 | 680 | 1968 | ||
| Dick Howser | 85 | 679 | 1968 | ||
| Al Rosen | 85 | 549 | 1952 | ||
| Whitey Kurowski | 85 | 634 | 1945 | ||
| Lee Handley | 85 | 589 | 1945 | ||
| Chuck Workman | 85 | 608 | 1944 | ||
| Red Rolfe | 85 | 562 | 1943 | ||
| Johnny Pesky | 85 | 580 | 1942 | ||
| Woody English | 85 | 675 | 1940 | ||
| 281. | Kevin Mitchell | 84 | 639 | 1989 | |
| Fred McGriff | 84 | 650 | 1987 | ||
| Dave Hostetler | 84 | 591 | 1987 | ||
| Larry Parrish | 84 | 633 | 1985 | ||
| George Brett | 84 | 664 | 1977 | ||
| Oscar Gamble | 84 | 529 | 1977 | ||
| Mike Shannon | 84 | 665 | 1974 | ||
| Joe Foy | 84 | 663 | 1973 | ||
| Bob Bailey | 84 | 590 | 1969 | ||
| Billy Williams | 84 | 657 | 1967 | ||
| Frankie Zak | 84 | 649 | 1954 | ||
| Arky Vaughan * | 84 | 655 | 1947 | ||
| Chuck Workman | 84 | 590 | 1947 | ||
| 294. | Tom O'Malley | 83 | 664 | 1988 | |
| Kevin Mitchell | 83 | 638 | 1987 | ||
| Eric Soderholm | 83 | 649 | 1982 | ||
| Oscar Gamble | 83 | 630 | 1981 | ||
| Tony Perez | 83 | 690 | 1977 | ||
| Joe Foy | 83 | 610 | 1974 | ||
| Mike Shannon | 83 | 664 | 1967 |
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