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| Third Basemen Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Bill Serena | 188 | 615 | 1961 | |
| 2. | Bill Serena | 185 | 662 | 1959 | |
| 3. | Bill Serena | 167 | 690 | 1958 | |
| 4. | Dave Hostetler | 164 | 647 | 1988 | |
| Eddie Mathews | 164 | 673 | 1967 | ||
| 6. | Harmon Killebrew * | 163 | 639 | 1956 | |
| 7. | Harmon Killebrew * | 160 | 665 | 1961 | |
| 8. | Fred Manrique | 159 | 674 | 1987 | |
| 9. | Larry Parrish | 157 | 611 | 1988 | |
| Bob Sadowski | 157 | 547 | 1961 | ||
| 11. | Mike Schmidt | 155 | 638 | 1984 | |
| Harmon Killebrew * | 155 | 620 | 1959 | ||
| 13. | Adolfo Phillips | 154 | 666 | 1972 | |
| 14. | Nick Esasky | 152 | 614 | 1988 | |
| Jim Fregosi | 152 | 608 | 1972 | ||
| 16. | Nick Esasky | 150 | 623 | 1986 | |
| Billy Grabarkewitz | 150 | 577 | 1972 | ||
| 18. | Bill Serena | 148 | 612 | 1960 | |
| 19. | Adolfo Phillips | 147 | 640 | 1971 | |
| Jim Fregosi | 147 | 601 | 1970 | ||
| Bill Serena | 147 | 668 | 1956 | ||
| 22. | Mike Schmidt | 146 | 681 | 1983 | |
| Jim Fregosi | 146 | 604 | 1971 | ||
| Dick Schofield | 146 | 540 | 1969 | ||
| 25. | Tony Phillips | 145 | 621 | 1984 | |
| 26. | Jim Fregosi | 144 | 623 | 1975 | |
| 27. | Adolfo Phillips | 141 | 614 | 1973 | |
| 28. | Doug Decinces | 139 | 594 | 1983 | |
| Bob Oliver | 139 | 592 | 1971 | ||
| Harmon Killebrew * | 139 | 618 | 1958 | ||
| 31. | Larry Parrish | 138 | 641 | 1987 | |
| Billy Grabarkewitz | 138 | 620 | 1974 | ||
| Bob Oliver | 138 | 589 | 1973 | ||
| 34. | Bill Serena | 137 | 681 | 1957 | |
| Harmon Killebrew * | 137 | 510 | 1955 | ||
| 36. | Dave Hostetler | 136 | 591 | 1987 | |
| Mack Jones | 136 | 625 | 1966 | ||
| Mack Jones | 136 | 625 | 1963 | ||
| 39. | Mike Schmidt | 135 | 660 | 1976 | |
| 40. | Kevin Mitchell | 134 | 638 | 1987 | |
| Oscar Gamble | 134 | 620 | 1985 | ||
| George Scott | 134 | 657 | 1978 | ||
| Darrell Evans | 134 | 585 | 1975 | ||
| Eddie Bressoud | 134 | 627 | 1963 | ||
| Harmon Killebrew * | 134 | 636 | 1960 | ||
| Harmon Killebrew * | 134 | 628 | 1957 | ||
| 47. | Ron Dunn | 133 | 663 | 1981 | |
| George Scott | 133 | 680 | 1976 | ||
| George Scott | 133 | 669 | 1969 | ||
| 50. | Mike Schmidt | 132 | 689 | 1975 | |
| 51. | Kevin Mitchell | 131 | 639 | 1989 | |
| Bob Oliver | 131 | 562 | 1974 | ||
| 53. | Willie Randolph | 130 | 572 | 1989 | |
| Larry Parrish | 130 | 516 | 1989 | ||
| Doug Decinces | 130 | 595 | 1982 | ||
| Harmon Killebrew * | 130 | 606 | 1972 | ||
| Mack Jones | 130 | 590 | 1964 | ||
| 58. | Mike Schmidt | 129 | 626 | 1982 | |
| Al Smith | 129 | 594 | 1959 | ||
| Harlond Clift | 129 | 592 | 1940 | ||
| 61. | Willie Randolph | 128 | 602 | 1988 | |
| Oscar Gamble | 128 | 588 | 1984 | ||
| Mike Schmidt | 128 | 655 | 1974 | ||
| Darrell Evans | 128 | 599 | 1974 | ||
| Eddie Bressoud | 128 | 486 | 1966 | ||
| Al Smith | 128 | 624 | 1960 | ||
| Harlond Clift | 128 | 580 | 1939 | ||
| 68. | Kevin Mitchell | 127 | 600 | 1984 | |
| Tony Perez | 127 | 690 | 1977 | ||
| Mike Schmidt | 127 | 646 | 1973 | ||
| 71. | Nick Esasky | 126 | 580 | 1990 | |
| Pete Ward | 126 | 602 | 1971 | ||
| Adolfo Phillips | 126 | 544 | 1970 | ||
| 74. | George Scott | 125 | 635 | 1977 | |
| Jim Fregosi | 125 | 595 | 1974 | ||
| Bob Oliver | 125 | 577 | 1972 | ||
| Harmon Killebrew * | 125 | 665 | 1969 | ||
| 78. | Tony Phillips | 124 | 597 | 1990 | |
| Adolfo Phillips | 124 | 620 | 1976 | ||
| Harmon Killebrew * | 124 | 673 | 1971 | ||
| Harmon Killebrew * | 124 | 651 | 1962 | ||
| 82. | Oscar Gamble | 123 | 666 | 1983 | |
| Ron Dunn | 123 | 557 | 1980 | ||
| 84. | Nick Esasky | 122 | 513 | 1984 | |
| Jim Fregosi | 122 | 477 | 1973 | ||
| 86. | Adolfo Phillips | 121 | 643 | 1975 | |
| Jim Fregosi | 121 | 614 | 1969 | ||
| 88. | Adolfo Phillips | 120 | 616 | 1969 | |
| 89. | Fred Manrique | 119 | 612 | 1988 | |
| Larry Parrish | 119 | 650 | 1983 | ||
| Mike Schmidt | 119 | 674 | 1980 | ||
| Bob Bailey | 119 | 684 | 1973 | ||
| Mack Jones | 119 | 523 | 1967 | ||
| Bill Serena | 119 | 675 | 1955 | ||
| 95. | Fred McGriff | 118 | 650 | 1987 | |
| Nick Esasky | 118 | 565 | 1985 | ||
| Doug Decinces | 118 | 573 | 1980 | ||
| Bob Robertson | 118 | 514 | 1977 | ||
| Adolfo Phillips | 118 | 552 | 1968 | ||
| 100. | George Scott | 117 | 665 | 1973 | |
| Eddie Mathews | 117 | 630 | 1966 | ||
| Joe Orengo | 117 | 676 | 1944 | ||
| 103. | Mike Schmidt | 116 | 698 | 1979 | |
| George Scott | 116 | 618 | 1971 | ||
| Eddie Mathews | 116 | 630 | 1965 | ||
| Mack Jones | 116 | 608 | 1965 | ||
| Bob Sadowski | 116 | 476 | 1965 | ||
| Bill Serena | 116 | 699 | 1953 | ||
| Ellis Clary | 116 | 601 | 1953 | ||
| Mel Ott * | 116 | 688 | 1946 | ||
| Mel Ott * | 116 | 626 | 1933 | ||
| 112. | Larry Parrish | 115 | 646 | 1978 | |
| Bob Bailey | 115 | 665 | 1972 | ||
| Harmon Killebrew * | 115 | 681 | 1963 | ||
| 115. | Tony Phillips | 114 | 542 | 1987 | |
| Larry Parrish | 114 | 644 | 1986 | ||
| George Scott | 114 | 613 | 1970 | ||
| Pete Ward | 114 | 550 | 1968 | ||
| Jim Fregosi | 114 | 620 | 1967 | ||
| Mel Ott * | 114 | 671 | 1945 | ||
| Mel Ott * | 114 | 641 | 1940 | ||
| 122. | Ron Cash | 113 | 669 | 1987 | |
| Ron Cey | 113 | 497 | 1982 | ||
| Rene Lachemann | 113 | 587 | 1981 | ||
| Harmon Killebrew * | 113 | 654 | 1970 | ||
| Pete Ward | 113 | 617 | 1967 | ||
| Bobby Thomson | 113 | 629 | 1958 | ||
| 128. | Fred Manrique | 112 | 590 | 1990 | |
| Larry Parrish | 112 | 633 | 1985 | ||
| Ron Cey | 112 | 592 | 1978 | ||
| Mike Schmidt | 112 | 671 | 1977 | ||
| Jose Pagan | 112 | 618 | 1969 | ||
| Mel Ott * | 112 | 632 | 1934 | ||
| 134. | Jim Presley | 111 | 582 | 1990 | |
| Nick Esasky | 111 | 572 | 1989 | ||
| Bob Bailey | 111 | 681 | 1970 | ||
| Eddie Mathews | 111 | 669 | 1963 | ||
| 138. | Kevin Mitchell | 110 | 636 | 1990 | |
| 139. | Mike Schmidt | 109 | 628 | 1981 | |
| Larry Parrish | 109 | 590 | 1976 | ||
| Adolfo Phillips | 109 | 596 | 1974 | ||
| George Scott | 109 | 661 | 1972 | ||
| Pete Ward | 109 | 577 | 1970 | ||
| Harmon Killebrew * | 109 | 671 | 1968 | ||
| Bob Bailey | 109 | 624 | 1964 | ||
| Eddie Mathews | 109 | 652 | 1962 | ||
| Mel Ott * | 109 | 677 | 1942 | ||
| 148. | Steve Buechele | 108 | 594 | 1987 | |
| Oscar Gamble | 108 | 630 | 1981 | ||
| Jim Ray Hart | 108 | 658 | 1976 | ||
| Tony Perez | 108 | 628 | 1976 | ||
| Doug Decinces | 108 | 518 | 1976 | ||
| Jim Ray Hart | 108 | 664 | 1974 | ||
| Harmon Killebrew * | 108 | 656 | 1964 | ||
| Jim Finigan | 108 | 582 | 1964 | ||
| Red Barkley | 108 | 500 | 1944 | ||
| 157. | Bob Horner | 107 | 646 | 1990 | |
| Mike Blowers | 107 | 468 | 1990 | ||
| Fred McGriff | 107 | 543 | 1989 | ||
| Jim Presley | 107 | 628 | 1987 | ||
| Ron Cey | 107 | 549 | 1981 | ||
| George Scott | 107 | 587 | 1979 | ||
| Bob Bailey | 107 | 666 | 1965 | ||
| Harlond Clift | 107 | 518 | 1941 | ||
| 165. | John Milner | 106 | 611 | 1986 | |
| Oscar Gamble | 106 | 688 | 1982 | ||
| Doug Decinces | 106 | 521 | 1981 | ||
| Oscar Gamble | 106 | 664 | 1980 | ||
| Ron Cey | 106 | 556 | 1976 | ||
| Ron Cey | 106 | 621 | 1975 | ||
| Tony Perez | 106 | 672 | 1970 | ||
| Dick Williams | 106 | 571 | 1959 | ||
| 173. | Fred McGriff | 105 | 661 | 1990 | |
| Larry Parrish | 105 | 662 | 1982 | ||
| Pete Ward | 105 | 414 | 1976 | ||
| Ed Spiezio | 105 | 554 | 1972 | ||
| Mike Shannon | 105 | 680 | 1968 | ||
| Dick Williams | 105 | 469 | 1966 | ||
| 179. | Jim Presley | 104 | 612 | 1989 | |
| Kevin Mitchell | 104 | 635 | 1988 | ||
| Willie Randolph | 104 | 599 | 1986 | ||
| Willie Randolph | 104 | 613 | 1985 | ||
| Willie Randolph | 104 | 630 | 1984 | ||
| Larry Parrish | 104 | 615 | 1984 | ||
| Harmon Killebrew * | 104 | 636 | 1967 | ||
| Harmon Killebrew * | 104 | 652 | 1965 | ||
| Jose Pagan | 104 | 533 | 1965 | ||
| Bill Serena | 104 | 384 | 1962 | ||
| Jim Finigan | 104 | 648 | 1961 | ||
| Bill Serena | 104 | 667 | 1954 | ||
| Al Rosen | 104 | 596 | 1954 | ||
| Mel Ott * | 104 | 663 | 1941 | ||
| 193. | Sal Bando | 103 | 627 | 1980 | |
| Tony Perez | 103 | 645 | 1972 | ||
| Sal Bando | 103 | 603 | 1970 | ||
| Bob Bailey | 103 | 667 | 1966 | ||
| Eddie Mathews | 103 | 608 | 1964 | ||
| Jim Finigan | 103 | 672 | 1958 | ||
| Eddie Bockman | 103 | 598 | 1952 | ||
| Bill Serena | 103 | 676 | 1951 | ||
| Mel Ott * | 103 | 520 | 1947 | ||
| Bobby Doerr | 103 | 551 | 1940 | ||
| 203. | Larry Parrish | 102 | 653 | 1981 | |
| Ron Cey | 102 | 515 | 1979 | ||
| Bob Bailey | 102 | 592 | 1968 | ||
| Eddie Mathews | 102 | 628 | 1959 | ||
| Al Rosen | 102 | 622 | 1955 | ||
| Red Barkley | 102 | 515 | 1940 | ||
| Harlond Clift | 102 | 598 | 1938 | ||
| 210. | Eric Soderholm | 101 | 497 | 1983 | |
| Sal Bando | 101 | 643 | 1976 | ||
| Bob Bailey | 101 | 646 | 1974 | ||
| Bob Bailey | 101 | 658 | 1971 | ||
| Max Alvis | 101 | 438 | 1963 | ||
| 215. | Rene Lachemann | 100 | 488 | 1976 | |
| George Scott | 100 | 600 | 1974 | ||
| Jim Fregosi | 100 | 483 | 1968 | ||
| Dick Williams | 100 | 496 | 1960 | ||
| 219. | Ron Dunn | 99 | 505 | 1984 | |
| Tony Phillips | 99 | 495 | 1983 | ||
| Eddie Mathews | 99 | 391 | 1968 | ||
| Al Rosen | 99 | 593 | 1951 | ||
| Bill Serena | 99 | 680 | 1950 | ||
| Mel Ott * | 99 | 684 | 1944 | ||
| 225. | Carmen Fanzone | 98 | 538 | 1978 | |
| Eddie Mathews | 98 | 636 | 1957 | ||
| 227. | Hector Cruz | 97 | 365 | 1989 | |
| Hector Cruz | 97 | 490 | 1988 | ||
| Bill Madlock | 97 | 568 | 1986 | ||
| Kevin Mitchell | 97 | 539 | 1985 | ||
| Elio Chacon | 97 | 602 | 1965 | ||
| Jose Pagan | 97 | 556 | 1963 | ||
| 233. | Ron Dunn | 96 | 547 | 1983 | |
| Bob Bailey | 96 | 590 | 1969 | ||
| Pete Ward | 96 | 630 | 1966 | ||
| Pete Ward | 96 | 616 | 1965 | ||
| Jim Finigan | 96 | 626 | 1963 | ||
| Eddie Mathews | 96 | 661 | 1960 | ||
| Jim Finigan | 96 | 615 | 1960 | ||
| Whitey Kurowski | 96 | 586 | 1953 | ||
| Al Rosen | 96 | 626 | 1949 | ||
| Mel Ott * | 96 | 609 | 1935 | ||
| 243. | Nick Esasky | 95 | 531 | 1987 | |
| Graig Nettles | 95 | 603 | 1978 | ||
| Bob Bailey | 95 | 647 | 1975 | ||
| Jim Ray Hart | 95 | 566 | 1975 | ||
| Tony Taylor | 95 | 653 | 1971 | ||
| Jim Finigan | 95 | 634 | 1959 | ||
| 249. | Ken Caminiti | 94 | 655 | 1988 | |
| Sal Bando | 94 | 607 | 1979 | ||
| Graig Nettles | 94 | 539 | 1979 | ||
| Joe Foy | 94 | 577 | 1977 | ||
| Rene Lachemann | 94 | 541 | 1977 | ||
| Bob Bailey | 94 | 626 | 1976 | ||
| Ron Cey | 94 | 541 | 1974 | ||
| Tony Perez | 94 | 616 | 1966 | ||
| Jim Finigan | 94 | 653 | 1962 | ||
| 258. | Fred McGriff | 93 | 664 | 1988 | |
| Eddie Leon | 93 | 470 | 1970 | ||
| Mike Shannon | 93 | 664 | 1967 | ||
| Tony Perez | 93 | 544 | 1965 | ||
| Ed Charles | 93 | 637 | 1962 | ||
| Johnny Vergez | 93 | 507 | 1938 | ||
| Mel Ott * | 93 | 642 | 1936 | ||
| 265. | Wayne Krenchicki | 92 | 632 | 1988 | |
| Jim Fregosi | 92 | 378 | 1976 | ||
| Mike Shannon | 92 | 665 | 1974 | ||
| Sal Bando | 92 | 582 | 1969 | ||
| Gair Allie | 92 | 387 | 1959 | ||
| Frankie Zak | 92 | 649 | 1954 | ||
| 271. | Kurt Bevacqua | 91 | 578 | 1982 | |
| Eric Soderholm | 91 | 614 | 1980 | ||
| Darrell Evans | 91 | 466 | 1976 | ||
| Billy Williams | 91 | 628 | 1974 | ||
| Billy Williams | 91 | 709 | 1972 | ||
| Tony Perez | 91 | 646 | 1969 | ||
| Dick Williams | 91 | 402 | 1962 | ||
| Snuffy Stirnweiss | 91 | 395 | 1956 | ||
| Mel Ott * | 91 | 611 | 1937 | ||
| 280. | Bob Horner | 90 | 562 | 1989 | |
| Dave Hostetler | 90 | 383 | 1989 | ||
| Wayne Gross | 90 | 449 | 1987 | ||
| Ron Dunn | 90 | 467 | 1978 | ||
| Billy Grabarkewitz | 90 | 380 | 1971 | ||
| Max Alvis | 90 | 557 | 1968 | ||
| Tony Perez | 90 | 641 | 1967 | ||
| Eddie Mathews | 90 | 652 | 1956 | ||
| 288. | Ken Caminiti | 89 | 660 | 1989 | |
| Dave Magadan | 89 | 580 | 1987 | ||
| Billy Williams | 89 | 698 | 1973 | ||
| Mike Shannon | 89 | 655 | 1970 | ||
| Eddie Mathews | 89 | 633 | 1958 | ||
| Frankie Zak | 89 | 505 | 1956 | ||
| Mel Ott * | 89 | 640 | 1938 | ||
| 295. | Dave Magadan | 88 | 541 | 1990 | |
| Wayne Gross | 88 | 578 | 1983 | ||
| Wayne Gross | 88 | 596 | 1980 | ||
| Toby Harrah | 88 | 510 | 1976 | ||
| Tony Perez | 88 | 608 | 1971 | ||
| Bob Robertson | 88 | 360 | 1969 |
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