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| Second Basemen Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Tommy Glaviano | 178 | 687 | 1959 | |
| 2. | Tommy Glaviano | 173 | 684 | 1956 | |
| 3. | Greg Luzinski | 164 | 609 | 1988 | |
| 4. | Tommy Glaviano | 160 | 572 | 1962 | |
| 5. | Greg Luzinski | 158 | 667 | 1985 | |
| 6. | Pee Wee Reese * | 154 | 596 | 1956 | |
| 7. | Juan Samuel | 152 | 614 | 1990 | |
| Tommy Glaviano | 152 | 515 | 1960 | ||
| 9. | Greg Luzinski | 148 | 666 | 1986 | |
| Greg Luzinski | 148 | 646 | 1973 | ||
| Tommy Glaviano | 148 | 577 | 1961 | ||
| 12. | Greg Luzinski | 147 | 669 | 1984 | |
| Joe Gordon | 147 | 532 | 1940 | ||
| 14. | Juan Samuel | 144 | 523 | 1989 | |
| Charley Smith | 144 | 581 | 1970 | ||
| Leo Burke | 144 | 535 | 1963 | ||
| 17. | Don Demeter | 143 | 547 | 1971 | |
| 18. | Jay Bell | 142 | 626 | 1987 | |
| Johnny Goryl | 142 | 588 | 1961 | ||
| 20. | Tommy Glaviano | 141 | 679 | 1958 | |
| 21. | Greg Luzinski | 140 | 612 | 1972 | |
| 22. | Tommy Glaviano | 139 | 570 | 1957 | |
| 23. | Jay Bell | 138 | 586 | 1988 | |
| Nelson Mathews | 138 | 576 | 1968 | ||
| 25. | Juan Samuel | 137 | 597 | 1984 | |
| 26. | Juan Samuel | 136 | 606 | 1987 | |
| Juan Samuel | 136 | 608 | 1985 | ||
| 28. | Paul Runge | 135 | 596 | 1987 | |
| Nelson Mathews | 135 | 592 | 1966 | ||
| 30. | Greg Luzinski | 134 | 677 | 1981 | |
| 31. | Don Demeter | 132 | 619 | 1960 | |
| 32. | Ryne Sandberg | 131 | 651 | 1990 | |
| Nelson Mathews | 131 | 571 | 1967 | ||
| 34. | Nelson Mathews | 130 | 590 | 1965 | |
| 35. | Bump Wills | 129 | 597 | 1988 | |
| 36. | Jay Bell | 128 | 582 | 1989 | |
| Joe Gordon | 128 | 598 | 1941 | ||
| 38. | Greg Luzinski | 127 | 644 | 1983 | |
| 39. | Juan Samuel | 126 | 596 | 1986 | |
| Joe Gordon | 126 | 524 | 1944 | ||
| 41. | Gary Geiger | 125 | 668 | 1963 | |
| Don Demeter | 125 | 616 | 1959 | ||
| 43. | Roy Smalley | 123 | 414 | 1960 | |
| Tommy Glaviano | 123 | 585 | 1955 | ||
| 45. | Paul Runge | 122 | 606 | 1986 | |
| 46. | Kiko Garcia | 121 | 534 | 1990 | |
| Don Demeter | 121 | 566 | 1969 | ||
| Roy Smalley | 121 | 501 | 1961 | ||
| Johnny Lipon | 121 | 482 | 1957 | ||
| 50. | Joe Morgan | 120 | 687 | 1980 | |
| 51. | Bobby Grich | 119 | 594 | 1984 | |
| Charley Smith | 119 | 592 | 1969 | ||
| Charley Smith | 119 | 435 | 1961 | ||
| Sherry Robertson | 119 | 551 | 1954 | ||
| 55. | Don Buddin | 118 | 511 | 1971 | |
| 56. | Rob Ellis | 117 | 525 | 1985 | |
| Don Buddin | 117 | 558 | 1958 | ||
| Joe Gordon | 117 | 605 | 1942 | ||
| 59. | Greg Luzinski | 116 | 664 | 1976 | |
| 60. | Don Buddin | 115 | 580 | 1969 | |
| 61. | Greg Luzinski | 114 | 644 | 1974 | |
| Chuck Schilling | 114 | 591 | 1973 | ||
| Johnny Goryl | 114 | 581 | 1966 | ||
| Lee Walls | 114 | 668 | 1960 | ||
| 65. | Ryne Sandberg | 113 | 623 | 1985 | |
| Greg Luzinski | 113 | 658 | 1977 | ||
| Nelson Mathews | 113 | 557 | 1972 | ||
| Gary Geiger | 113 | 530 | 1962 | ||
| Lee Walls | 113 | 687 | 1961 | ||
| Don Demeter | 113 | 607 | 1961 | ||
| 71. | Kiko Garcia | 112 | 593 | 1989 | |
| Ryne Sandberg | 112 | 641 | 1988 | ||
| Bobby Grich | 112 | 593 | 1979 | ||
| Don Demeter | 112 | 646 | 1967 | ||
| Johnny Goryl | 112 | 575 | 1964 | ||
| 76. | Jorge Orta | 111 | 562 | 1987 | |
| Joel Youngblood | 111 | 587 | 1985 | ||
| Bobby Grich | 111 | 472 | 1985 | ||
| 79. | Ryne Sandberg | 110 | 631 | 1987 | |
| 80. | Gil McDougald * | 109 | 672 | 1961 | |
| George Strickland | 109 | 567 | 1960 | ||
| Roy Hartsfield | 109 | 634 | 1958 | ||
| 83. | Paul Runge | 108 | 491 | 1989 | |
| Joel Youngblood | 108 | 582 | 1986 | ||
| Sergio Ferrer | 108 | 522 | 1981 | ||
| Marv Breeding | 108 | 556 | 1968 | ||
| Gil McDougald * | 108 | 649 | 1962 | ||
| 88. | Paul Runge | 107 | 601 | 1988 | |
| Robby Thompson | 107 | 580 | 1986 | ||
| Greg Luzinski | 107 | 663 | 1979 | ||
| Lee Walls | 107 | 706 | 1962 | ||
| 92. | Luis Aguayo | 106 | 505 | 1986 | |
| Ryne Sandberg | 106 | 558 | 1984 | ||
| Bobby Grich | 106 | 600 | 1981 | ||
| Joe Caffie | 106 | 606 | 1965 | ||
| Don Demeter | 106 | 635 | 1963 | ||
| Tony Lazzeri * | 106 | 639 | 1939 | ||
| 98. | Ryne Sandberg | 105 | 633 | 1989 | |
| Tim Teufel | 105 | 496 | 1988 | ||
| Jorge Orta | 105 | 459 | 1988 | ||
| Willie Horton | 105 | 655 | 1969 | ||
| Don Demeter | 105 | 531 | 1968 | ||
| 103. | Bobby Grich | 104 | 553 | 1983 | |
| Leo Cardenas | 104 | 665 | 1968 | ||
| Gil McDougald * | 104 | 613 | 1959 | ||
| Tony Lazzeri * | 104 | 493 | 1940 | ||
| 107. | Greg Luzinski | 103 | 637 | 1982 | |
| Willie Horton | 103 | 602 | 1978 | ||
| Bobby Knoop | 103 | 578 | 1974 | ||
| Joe Morgan | 103 | 689 | 1972 | ||
| Wayne Comer | 103 | 582 | 1970 | ||
| Lee Walls | 103 | 690 | 1963 | ||
| Al Kozar | 103 | 556 | 1955 | ||
| Tommy Glaviano | 103 | 666 | 1951 | ||
| Johnny Lucadello | 103 | 601 | 1951 | ||
| Billy Myers | 103 | 631 | 1937 | ||
| 117. | Paul Runge | 102 | 541 | 1990 | |
| Joe Morgan | 102 | 684 | 1979 | ||
| Gil McDougald * | 102 | 545 | 1964 | ||
| George Strickland | 102 | 548 | 1959 | ||
| 121. | Kiko Garcia | 101 | 641 | 1985 | |
| Sergio Ferrer | 101 | 525 | 1982 | ||
| Charley Smith | 101 | 548 | 1971 | ||
| Joe Morgan | 101 | 712 | 1970 | ||
| Joe Morgan | 101 | 717 | 1969 | ||
| George Strickland | 101 | 648 | 1958 | ||
| Don Zimmer | 101 | 615 | 1957 | ||
| Joe Gordon | 101 | 441 | 1943 | ||
| Jimmie Dykes | 101 | 581 | 1932 | ||
| 130. | Rance Mulliniks | 100 | 681 | 1988 | |
| Juan Samuel | 100 | 536 | 1983 | ||
| 132. | Kevin Elster | 99 | 488 | 1988 | |
| Tim Teufel | 99 | 490 | 1986 | ||
| Bobby Grich | 99 | 643 | 1973 | ||
| Lee Walls | 99 | 630 | 1959 | ||
| Tommy Glaviano | 99 | 476 | 1954 | ||
| Lou Stringer | 99 | 481 | 1953 | ||
| 138. | Kevin Elster | 98 | 507 | 1990 | |
| Greg Luzinski | 98 | 664 | 1978 | ||
| Joe Morgan | 98 | 681 | 1977 | ||
| Willie Horton | 98 | 674 | 1974 | ||
| Chuck Schilling | 98 | 586 | 1972 | ||
| Johnny Goryl | 98 | 560 | 1968 | ||
| Gil McDougald * | 98 | 635 | 1960 | ||
| 145. | Gene Stephens | 97 | 659 | 1965 | |
| Don Buddin | 97 | 452 | 1959 | ||
| Ted Lepcio | 97 | 558 | 1954 | ||
| 148. | Ryne Sandberg | 96 | 606 | 1986 | |
| Davey Lopes | 96 | 586 | 1977 | ||
| Nelson Mathews | 96 | 502 | 1969 | ||
| Gary Geiger | 96 | 364 | 1961 | ||
| 152. | Tim Teufel | 95 | 515 | 1987 | |
| Mariano Duncan | 95 | 488 | 1986 | ||
| Wayne Comer | 95 | 577 | 1971 | ||
| Lee Walls | 95 | 672 | 1966 | ||
| Johnny Goryl | 95 | 597 | 1963 | ||
| Lee Walls | 95 | 576 | 1958 | ||
| George Strickland | 95 | 635 | 1956 | ||
| 159. | Derrel Thomas | 94 | 580 | 1982 | |
| Nelson Mathews | 94 | 446 | 1970 | ||
| Don Demeter | 94 | 626 | 1962 | ||
| Gil McDougald * | 94 | 682 | 1957 | ||
| Solly Hemus | 94 | 629 | 1957 | ||
| Ed Montague | 94 | 578 | 1938 | ||
| Max Bishop | 94 | 629 | 1934 | ||
| 166. | Willie Horton | 93 | 644 | 1972 | |
| Bobby Knoop | 93 | 558 | 1972 | ||
| Willie Horton | 93 | 687 | 1971 | ||
| Joe Morgan | 93 | 636 | 1968 | ||
| Johnny Bero | 93 | 526 | 1949 | ||
| 171. | Robby Thompson | 92 | 593 | 1987 | |
| Bobby Grich | 92 | 561 | 1980 | ||
| Chuck Schilling | 92 | 679 | 1968 | ||
| Joe Morgan | 92 | 640 | 1967 | ||
| Dick Green | 92 | 524 | 1967 | ||
| Gene Stephens | 92 | 631 | 1966 | ||
| Don Demeter | 92 | 481 | 1964 | ||
| Gil McDougald * | 92 | 621 | 1963 | ||
| Hank Thompson | 92 | 595 | 1959 | ||
| Sherry Robertson | 92 | 449 | 1953 | ||
| Johnny Lucadello | 92 | 477 | 1952 | ||
| Wally Kimmick | 92 | 500 | 1933 | ||
| 183. | Tim Hulett | 91 | 486 | 1984 | |
| Bump Wills | 91 | 664 | 1980 | ||
| Chuck Schilling | 91 | 627 | 1971 | ||
| Willie Horton | 91 | 594 | 1967 | ||
| Joe Morgan | 91 | 710 | 1966 | ||
| Lee Walls | 91 | 648 | 1965 | ||
| Gary Geiger | 91 | 634 | 1965 | ||
| Roy Hartsfield | 91 | 674 | 1956 | ||
| 191. | Kevin Elster | 90 | 532 | 1989 | |
| Kiko Garcia | 90 | 601 | 1988 | ||
| Derrel Thomas | 90 | 518 | 1981 | ||
| Greg Luzinski | 90 | 577 | 1980 | ||
| Joe Morgan | 90 | 611 | 1973 | ||
| Gary Geiger | 90 | 583 | 1964 | ||
| Gil McDougald * | 90 | 701 | 1956 | ||
| Sherry Robertson | 90 | 393 | 1955 | ||
| 199. | Tom Herr | 89 | 658 | 1990 | |
| Nelson Liriano | 89 | 594 | 1990 | ||
| Robby Thompson | 89 | 610 | 1989 | ||
| Robby Thompson | 89 | 552 | 1988 | ||
| Dan Monzon | 89 | 491 | 1975 | ||
| Dan Monzon | 89 | 526 | 1974 | ||
| Joe Morgan | 89 | 711 | 1971 | ||
| Bobby Knoop | 89 | 432 | 1970 | ||
| Johnny Goryl | 89 | 423 | 1969 | ||
| Roy Hartsfield | 89 | 606 | 1957 | ||
| 209. | Joel Youngblood | 88 | 600 | 1983 | |
| Joe Morgan | 88 | 628 | 1978 | ||
| Joe Morgan | 88 | 626 | 1974 | ||
| Willie Horton | 88 | 680 | 1973 | ||
| Gary Geiger | 88 | 591 | 1971 | ||
| Rod Carew | 88 | 569 | 1967 | ||
| Chico Carrasquel | 88 | 461 | 1964 | ||
| Gil McDougald * | 88 | 678 | 1958 | ||
| George Strickland | 88 | 592 | 1957 | ||
| Alex Kampouris | 88 | 584 | 1945 | ||
| Billy Myers | 88 | 514 | 1936 | ||
| 220. | Steve Sax | 87 | 650 | 1985 | |
| Derrel Thomas | 87 | 520 | 1983 | ||
| Cal Ripken Jr. | 87 | 503 | 1983 | ||
| Joel Youngblood | 87 | 541 | 1977 | ||
| Mike De La Hoz | 87 | 514 | 1975 | ||
| Greg Luzinski | 87 | 507 | 1975 | ||
| Bobby Knoop | 87 | 601 | 1973 | ||
| Don Demeter | 87 | 555 | 1966 | ||
| Hank Thompson | 87 | 606 | 1960 | ||
| Frank Bolling | 87 | 573 | 1959 | ||
| Lee Walls | 87 | 624 | 1957 | ||
| Alex Kampouris | 87 | 451 | 1948 | ||
| 232. | Tim Teufel | 86 | 490 | 1985 | |
| Joel Youngblood | 86 | 573 | 1984 | ||
| Marty Martinez | 86 | 655 | 1972 | ||
| Jim Lefebvre | 86 | 609 | 1966 | ||
| Solly Hemus | 86 | 668 | 1956 | ||
| Alex Kampouris | 86 | 664 | 1936 | ||
| 238. | Bobby Grich | 85 | 536 | 1982 | |
| Bobby Grich | 85 | 699 | 1977 | ||
| Bobby Grich | 85 | 631 | 1974 | ||
| Jim Lefebvre | 85 | 591 | 1973 | ||
| Gary Geiger | 85 | 635 | 1969 | ||
| Bobby Knoop | 85 | 418 | 1969 | ||
| George Strickland | 85 | 562 | 1955 | ||
| Tommy Glaviano | 85 | 422 | 1952 | ||
| Lou Stringer | 85 | 660 | 1951 | ||
| Johnny Hodapp | 85 | 490 | 1939 | ||
| 248. | Tom Brookens | 84 | 631 | 1985 | |
| Pedro Garcia | 84 | 636 | 1984 | ||
| Jim Lefebvre | 84 | 596 | 1972 | ||
| Lee Walls | 84 | 575 | 1964 | ||
| Ted Lepcio | 84 | 417 | 1964 | ||
| Joe Caffie | 84 | 587 | 1963 | ||
| Hank Thompson | 84 | 627 | 1957 | ||
| Johnny Lipon | 84 | 460 | 1955 | ||
| Sherry Robertson | 84 | 496 | 1946 | ||
| Alex Kampouris | 84 | 648 | 1944 | ||
| Tony Lazzeri * | 84 | 641 | 1938 | ||
| 259. | Jay Bell | 83 | 310 | 1990 | |
| Bump Wills | 83 | 483 | 1986 | ||
| Bobby Grich | 83 | 689 | 1975 | ||
| Lee Lacy | 83 | 643 | 1974 | ||
| Gary Geiger | 83 | 577 | 1966 | ||
| Gene Stephens | 83 | 572 | 1962 | ||
| Solly Hemus | 83 | 503 | 1958 | ||
| Alex Kampouris | 83 | 610 | 1940 | ||
| 267. | Rance Mulliniks | 82 | 664 | 1986 | |
| Leo Cardenas | 82 | 474 | 1975 | ||
| Jim Lefebvre | 82 | 641 | 1970 | ||
| Leo Cardenas | 82 | 547 | 1966 | ||
| Leo Cardenas | 82 | 483 | 1963 | ||
| Chico Carrasquel | 82 | 593 | 1962 | ||
| Granny Hamner | 82 | 286 | 1960 | ||
| Billy Gardner | 82 | 524 | 1959 | ||
| Jake Flowers | 82 | 402 | 1935 | ||
| Lew Malone | 82 | 510 | 1931 | ||
| 277. | Cal Ripken Jr. | 81 | 512 | 1988 | |
| Tom Brookens | 81 | 594 | 1986 | ||
| Rob Ellis | 81 | 310 | 1986 | ||
| Bump Wills | 81 | 688 | 1985 | ||
| Rudy Meoli | 81 | 544 | 1985 | ||
| Tim Teufel | 81 | 482 | 1983 | ||
| Glenn Hubbard | 81 | 491 | 1981 | ||
| Terry Harmon | 81 | 592 | 1972 | ||
| Nelson Mathews | 81 | 346 | 1971 | ||
| Willie Horton | 81 | 654 | 1970 | ||
| Chuck Schilling | 81 | 610 | 1970 | ||
| Charley Smith | 81 | 485 | 1967 | ||
| Don Buddin | 81 | 354 | 1962 | ||
| Lou Stringer | 81 | 660 | 1952 | ||
| Billy Myers | 81 | 553 | 1943 | ||
| 292. | Jack Perconte | 80 | 429 | 1990 | |
| Rance Mulliniks | 80 | 637 | 1987 | ||
| Vance Law | 80 | 513 | 1984 | ||
| Rob Ellis | 80 | 549 | 1982 | ||
| Davey Lopes | 80 | 557 | 1978 | ||
| Terry Harmon | 80 | 671 | 1976 | ||
| Tom Upton | 80 | 636 | 1961 | ||
| Gene Stephens | 80 | 591 | 1956 | ||
| Tommy Glaviano | 80 | 468 | 1953 |
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