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| Second Basemen Single-Season At-Bats Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | At-Bats | PA | Year | Career Leaderboard |
| 1. | Babe Ellison | 657 | 690 | 1930 | |
| 2. | Billy Cox | 646 | 710 | 1955 | |
| 3. | Paul Molitor | 644 | 688 | 1987 | |
| 4. | Ozzie Guillen | 643 | 657 | 1985 | |
| 5. | Pee Wee Reese * | 639 | 723 | 1943 | |
| 6. | Billy Cox | 638 | 701 | 1949 | |
| Freddy Spurgeon | 638 | 689 | 1931 | ||
| 8. | Bump Wills | 636 | 721 | 1983 | |
| 9. | Lee Walls | 634 | 706 | 1962 | |
| 10. | Rob Andrews | 629 | 677 | 1977 | |
| Willie Horton | 629 | 674 | 1974 | ||
| Bob Barrett | 629 | 657 | 1931 | ||
| 13. | Lee Walls | 628 | 687 | 1961 | |
| 14. | Rance Mulliniks | 626 | 681 | 1988 | |
| Stan Hack | 626 | 716 | 1943 | ||
| 16. | Jorge Orta | 625 | 663 | 1980 | |
| Willie Horton | 625 | 680 | 1973 | ||
| Lee Walls | 625 | 690 | 1963 | ||
| 19. | Roy Hartsfield | 624 | 674 | 1956 | |
| 20. | Billy Johnson | 623 | 677 | 1955 | |
| Bobby Reeves | 623 | 682 | 1931 | ||
| 22. | Pete Runnels | 622 | 709 | 1960 | |
| 23. | Stan Hack | 621 | 711 | 1938 | |
| 24. | Lou Whitaker | 620 | 681 | 1983 | |
| 25. | Lou Whitaker | 619 | 678 | 1980 | |
| Lee Walls | 619 | 672 | 1966 | ||
| Pee Wee Reese * | 619 | 740 | 1954 | ||
| Pee Wee Reese * | 619 | 736 | 1948 | ||
| 29. | Rance Mulliniks | 618 | 664 | 1986 | |
| Willie Horton | 618 | 687 | 1971 | ||
| Billy Cox | 618 | 677 | 1952 | ||
| Pee Wee Reese * | 618 | 724 | 1944 | ||
| Stan Hack | 618 | 714 | 1942 | ||
| 34. | Felix Millan | 617 | 649 | 1968 | |
| Gil McDougald * | 617 | 672 | 1961 | ||
| Gil McDougald * | 617 | 701 | 1956 | ||
| 37. | Pee Wee Reese * | 616 | 710 | 1952 | |
| Bill Regan | 616 | 655 | 1931 | ||
| 39. | Lou Whitaker | 615 | 681 | 1987 | |
| Leo Cardenas | 615 | 665 | 1968 | ||
| Hughie Critz | 615 | 630 | 1932 | ||
| Rogers Hornsby | 615 | 678 | 1930 | ||
| 43. | Mark Koenig | 614 | 653 | 1936 | |
| 44. | Roy Hartsfield | 613 | 670 | 1951 | |
| Bob Barrett | 613 | 639 | 1930 | ||
| 46. | Steve Sax | 612 | 650 | 1985 | |
| Mark Koenig | 612 | 646 | 1931 | ||
| 48. | Don Blasingame | 611 | 668 | 1960 | |
| Stan Hack | 611 | 699 | 1939 | ||
| 50. | Tom Herr | 610 | 658 | 1990 | |
| Paul Molitor | 610 | 655 | 1990 | ||
| Stan Hack | 610 | 691 | 1941 | ||
| 53. | Rick Manning | 609 | 652 | 1982 | |
| Lee Lacy | 609 | 655 | 1981 | ||
| Billy Cox | 609 | 687 | 1950 | ||
| 56. | Roberto Alomar | 607 | 662 | 1989 | |
| Charlie Gehringer | 607 | 685 | 1930 | ||
| 58. | Pepe Frias | 606 | 640 | 1983 | |
| 59. | Willie Horton | 605 | 654 | 1970 | |
| Billy Cox | 605 | 682 | 1951 | ||
| Pee Wee Reese * | 605 | 678 | 1942 | ||
| 62. | Lou Whitaker | 604 | 661 | 1990 | |
| Paul Schaal | 604 | 678 | 1971 | ||
| Roy Hartsfield | 604 | 634 | 1958 | ||
| Dutch Meyer | 604 | 652 | 1947 | ||
| 66. | Jerry Terrell | 603 | 637 | 1977 | |
| Lee Lacy | 603 | 643 | 1974 | ||
| Cecil Travis | 603 | 658 | 1936 | ||
| 69. | Tom Herr | 602 | 667 | 1988 | |
| Gil McDougald * | 602 | 682 | 1957 | ||
| 71. | Tom Herr | 601 | 664 | 1989 | |
| Willie Horton | 601 | 655 | 1969 | ||
| Billy Myers | 601 | 639 | 1938 | ||
| 74. | Bip Roberts | 600 | 661 | 1989 | |
| Paul Molitor | 600 | 650 | 1981 | ||
| 76. | Bump Wills | 599 | 688 | 1985 | |
| Greg Luzinski | 599 | 677 | 1981 | ||
| 78. | Paul Molitor | 598 | 670 | 1986 | |
| Lee Lacy | 598 | 636 | 1982 | ||
| Don Blasingame | 598 | 657 | 1958 | ||
| 81. | Randy Ready | 597 | 684 | 1988 | |
| Tom Herr | 597 | 646 | 1982 | ||
| Bobby Grich | 597 | 699 | 1977 | ||
| 84. | Paul Molitor | 596 | 651 | 1985 | |
| Paul Molitor | 596 | 657 | 1984 | ||
| Marty Martinez | 596 | 670 | 1973 | ||
| Bobby Avila | 596 | 691 | 1954 | ||
| Billy Cox | 596 | 675 | 1954 | ||
| 89. | Pedro Garcia | 595 | 636 | 1984 | |
| Paul Molitor | 595 | 647 | 1983 | ||
| Joe Morgan | 595 | 710 | 1966 | ||
| 92. | Greg Luzinski | 594 | 666 | 1986 | |
| Mickey Rivers | 594 | 638 | 1982 | ||
| Rick Manning | 594 | 635 | 1981 | ||
| Terry Harmon | 594 | 671 | 1976 | ||
| Rod Carew | 594 | 645 | 1970 | ||
| Lee Walls | 594 | 668 | 1960 | ||
| Gil McDougald * | 594 | 678 | 1958 | ||
| Billy Cox | 594 | 660 | 1953 | ||
| Grady Hatton | 594 | 703 | 1951 | ||
| Pee Wee Reese * | 594 | 698 | 1946 | ||
| Jerry Standaert | 594 | 652 | 1931 | ||
| 103. | Rodney Scott | 593 | 686 | 1983 | |
| Joe Morgan | 593 | 687 | 1980 | ||
| Bobby Grich | 593 | 689 | 1975 | ||
| Stan Hack | 593 | 677 | 1944 | ||
| 107. | Johnny Hodapp | 592 | 654 | 1938 | |
| 108. | Jack Perconte | 591 | 649 | 1984 | |
| Bump Wills | 591 | 664 | 1980 | ||
| Rod Carew | 591 | 633 | 1971 | ||
| Joe Morgan | 591 | 717 | 1969 | ||
| Gary Geiger | 591 | 668 | 1963 | ||
| Bob Johnson | 591 | 635 | 1963 | ||
| Pete Runnels | 591 | 665 | 1961 | ||
| 115. | Jose Oquendo | 590 | 696 | 1988 | |
| Paul Schaal | 590 | 663 | 1967 | ||
| Alex Kampouris | 590 | 664 | 1936 | ||
| 118. | Paul Molitor | 589 | 643 | 1982 | |
| Paul Molitor | 589 | 634 | 1979 | ||
| Willie Horton | 589 | 644 | 1972 | ||
| Lee Walls | 589 | 655 | 1967 | ||
| Lee Walls | 589 | 648 | 1965 | ||
| 123. | Terry Harmon | 588 | 649 | 1973 | |
| Chuck Schilling | 588 | 679 | 1968 | ||
| Pee Wee Reese * | 588 | 700 | 1949 | ||
| Cecil Travis | 588 | 640 | 1943 | ||
| 127. | Paul Molitor | 587 | 645 | 1988 | |
| Lou Whitaker | 587 | 656 | 1986 | ||
| Joe Morgan | 587 | 684 | 1979 | ||
| Greg Luzinski | 587 | 664 | 1976 | ||
| Billy Herman | 587 | 648 | 1935 | ||
| 132. | Lou Whitaker | 586 | 660 | 1982 | |
| Rod Carew | 586 | 637 | 1968 | ||
| Grady Hatton | 586 | 687 | 1953 | ||
| Pee Wee Reese * | 586 | 724 | 1950 | ||
| Stan Hack | 586 | 665 | 1936 | ||
| 137. | Rance Mulliniks | 585 | 637 | 1987 | |
| Greg Luzinski | 585 | 663 | 1979 | ||
| Jorge Orta | 585 | 642 | 1977 | ||
| Lee Lacy | 585 | 627 | 1973 | ||
| Don Demeter | 585 | 626 | 1962 | ||
| Chico Carrasquel | 585 | 647 | 1952 | ||
| 143. | Taylor Duncan | 584 | 603 | 1979 | |
| Lee Lacy | 584 | 629 | 1978 | ||
| Terry Harmon | 584 | 644 | 1974 | ||
| Gil McDougald * | 584 | 649 | 1962 | ||
| 147. | Ted Sizemore | 583 | 630 | 1975 | |
| Don Demeter | 583 | 646 | 1967 | ||
| Tony Lazzeri * | 583 | 673 | 1930 | ||
| 150. | Greg Luzinski | 582 | 669 | 1984 | |
| Joe Morgan | 582 | 711 | 1971 | ||
| Bobby Avila | 582 | 688 | 1953 | ||
| Grady Hatton | 582 | 689 | 1952 | ||
| Grady Hatton | 582 | 708 | 1950 | ||
| Billy Myers | 582 | 631 | 1937 | ||
| Cecil Travis | 582 | 630 | 1937 | ||
| Jerry Standaert | 582 | 624 | 1930 | ||
| 158. | Tom Brookens | 581 | 631 | 1985 | |
| Rick Manning | 581 | 607 | 1983 | ||
| Greg Luzinski | 581 | 646 | 1973 | ||
| Don Blasingame | 581 | 629 | 1970 | ||
| Pete Runnels | 581 | 678 | 1958 | ||
| Jim Bucher | 581 | 626 | 1940 | ||
| George Grantham | 581 | 676 | 1930 | ||
| 165. | Jorge Orta | 580 | 627 | 1979 | |
| Bobby Grich | 580 | 680 | 1976 | ||
| Don Blasingame | 580 | 636 | 1962 | ||
| Pee Wee Reese * | 580 | 682 | 1953 | ||
| George Grantham | 580 | 669 | 1931 | ||
| 170. | Juan Samuel | 579 | 614 | 1990 | |
| Bump Wills | 579 | 650 | 1982 | ||
| Mickey Rivers | 579 | 607 | 1980 | ||
| Greg Luzinski | 579 | 658 | 1977 | ||
| Lee Lacy | 579 | 623 | 1975 | ||
| Rod Carew | 579 | 631 | 1974 | ||
| Bob Johnson | 579 | 619 | 1964 | ||
| Don Zimmer | 579 | 615 | 1957 | ||
| Pee Wee Reese * | 579 | 710 | 1947 | ||
| Johnny Lucadello | 579 | 648 | 1942 | ||
| Fresco Thompson | 579 | 638 | 1933 | ||
| Fresco Thompson | 579 | 624 | 1931 | ||
| 182. | Lou Stringer | 578 | 660 | 1950 | |
| 183. | Ryne Sandberg | 577 | 631 | 1987 | |
| Greg Luzinski | 577 | 667 | 1985 | ||
| Tom Herr | 577 | 631 | 1984 | ||
| Bump Wills | 577 | 668 | 1981 | ||
| Bobby Avila | 577 | 676 | 1955 | ||
| Tony Lazzeri * | 577 | 661 | 1936 | ||
| 189. | Jorge Orta | 576 | 621 | 1981 | |
| 190. | Joe Morgan | 575 | 712 | 1970 | |
| Tom Upton | 575 | 643 | 1959 | ||
| Roy Hartsfield | 575 | 623 | 1950 | ||
| Jim Bucher | 575 | 634 | 1946 | ||
| Alex Kampouris | 575 | 682 | 1943 | ||
| 195. | Ryne Sandberg | 574 | 651 | 1990 | |
| Jim Gilliam | 574 | 660 | 1962 | ||
| Billy Cox | 574 | 625 | 1956 | ||
| 198. | Joe Morgan | 573 | 689 | 1972 | |
| Gil McDougald * | 573 | 662 | 1953 | ||
| Hughie Critz | 573 | 610 | 1931 | ||
| 201. | Gene Stephens | 572 | 659 | 1965 | |
| Tommy Glaviano | 572 | 687 | 1959 | ||
| Bama Rowell | 572 | 604 | 1945 | ||
| Johnny Hodapp | 572 | 622 | 1937 | ||
| 205. | Tom Herr | 571 | 639 | 1983 | |
| Gary Geiger | 571 | 635 | 1969 | ||
| Lee Walls | 571 | 630 | 1959 | ||
| Solly Hemus | 571 | 668 | 1956 | ||
| Gil McDougald * | 571 | 674 | 1954 | ||
| Grady Hatton | 571 | 693 | 1949 | ||
| Cecil Travis | 571 | 617 | 1944 | ||
| Stan Hack | 571 | 680 | 1934 | ||
| Mark Koenig | 571 | 628 | 1930 | ||
| 214. | Ryne Sandberg | 570 | 641 | 1988 | |
| Jack Perconte | 570 | 637 | 1987 | ||
| Damaso Garcia | 570 | 617 | 1987 | ||
| Marty Martinez | 570 | 655 | 1972 | ||
| Willie Horton | 570 | 596 | 1966 | ||
| Lou Stringer | 570 | 673 | 1949 | ||
| Johnny Hodapp | 570 | 641 | 1936 | ||
| Stan Hack | 570 | 650 | 1935 | ||
| 222. | Ryne Sandberg | 569 | 623 | 1985 | |
| Lee Lacy | 569 | 605 | 1984 | ||
| Paul Molitor | 569 | 628 | 1980 | ||
| Rod Carew | 569 | 613 | 1969 | ||
| Lou Stringer | 569 | 660 | 1952 | ||
| Red Schoendienst | 569 | 618 | 1949 | ||
| Stan Hack | 569 | 642 | 1937 | ||
| 229. | Barbaro Garbey | 568 | 594 | 1986 | |
| Kiko Garcia | 568 | 641 | 1985 | ||
| Rod Carew | 568 | 618 | 1973 | ||
| Joe Caffie | 568 | 606 | 1965 | ||
| Gil McDougald * | 568 | 635 | 1960 | ||
| Gene Stephens | 568 | 645 | 1955 | ||
| Eddie Stanky | 568 | 706 | 1944 | ||
| 236. | Tom Herr | 567 | 638 | 1987 | |
| Lee Lacy | 567 | 611 | 1977 | ||
| Rod Carew | 567 | 626 | 1972 | ||
| Don Demeter | 567 | 635 | 1963 | ||
| 240. | Jack Perconte | 566 | 626 | 1986 | |
| Bump Wills | 566 | 640 | 1984 | ||
| Derrel Thomas | 566 | 639 | 1979 | ||
| Greg Luzinski | 566 | 664 | 1978 | ||
| Ted Sizemore | 566 | 625 | 1971 | ||
| Gary Geiger | 566 | 619 | 1970 | ||
| Gil McDougald * | 566 | 621 | 1963 | ||
| Gil McDougald * | 566 | 657 | 1952 | ||
| Billy Johnson | 566 | 647 | 1950 | ||
| 249. | Duane Kuiper | 565 | 599 | 1979 | |
| Chuck Schilling | 565 | 645 | 1969 | ||
| Pete Runnels | 565 | 628 | 1963 | ||
| Billy Johnson | 565 | 627 | 1944 | ||
| Alex Kampouris | 565 | 642 | 1938 | ||
| Tony Lazzeri * | 565 | 656 | 1937 | ||
| Jerry Standaert | 565 | 610 | 1932 | ||
| Jimmie Dykes | 565 | 670 | 1930 | ||
| 257. | Rance Mulliniks | 564 | 624 | 1990 | |
| Mickey Rivers | 564 | 585 | 1981 | ||
| Ted Sizemore | 564 | 604 | 1979 | ||
| Joe Morgan | 564 | 681 | 1977 | ||
| Felix Millan | 564 | 616 | 1969 | ||
| Don Demeter | 564 | 619 | 1960 | ||
| Don Demeter | 564 | 616 | 1959 | ||
| Billy Johnson | 564 | 635 | 1952 | ||
| Lou Stringer | 564 | 660 | 1951 | ||
| 266. | Marty Martinez | 563 | 634 | 1971 | |
| Jim Lefebvre | 563 | 641 | 1970 | ||
| Stan Hack | 563 | 643 | 1945 | ||
| 269. | Rance Mulliniks | 562 | 625 | 1989 | |
| Greg Luzinski | 562 | 644 | 1983 | ||
| Roy Hartsfield | 562 | 606 | 1957 | ||
| 272. | Cotton Tierney | 561 | 602 | 1930 | |
| 273. | Mark Koenig | 560 | 612 | 1935 | |
| Max Bishop | 560 | 688 | 1930 | ||
| 275. | Jack Perconte | 559 | 616 | 1988 | |
| Julio Gonzalez | 559 | 590 | 1980 | ||
| Paul Schaal | 559 | 640 | 1966 | ||
| Tom Upton | 559 | 636 | 1961 | ||
| Fresco Thompson | 559 | 609 | 1930 | ||
| 280. | Kiko Garcia | 558 | 627 | 1984 | |
| Greg Luzinski | 558 | 637 | 1982 | ||
| Jorge Orta | 558 | 611 | 1978 | ||
| Tommy Glaviano | 558 | 679 | 1958 | ||
| Lee Walls | 558 | 624 | 1957 | ||
| Billy Cox | 558 | 595 | 1957 | ||
| 286. | Jay Bell | 557 | 626 | 1987 | |
| Juan Samuel | 557 | 606 | 1987 | ||
| Bump Wills | 557 | 620 | 1978 | ||
| Rod Carew | 557 | 615 | 1976 | ||
| Bobby Knoop | 557 | 601 | 1973 | ||
| Mike De La Hoz | 557 | 604 | 1964 | ||
| Chico Carrasquel | 557 | 618 | 1957 | ||
| Max Bishop | 557 | 697 | 1931 | ||
| Riggs Stephenson | 557 | 637 | 1930 | ||
| 295. | Gary Geiger | 556 | 634 | 1965 | |
| Frank Bolling | 556 | 603 | 1958 | ||
| Billy Johnson | 556 | 624 | 1954 | ||
| Pee Wee Reese * | 556 | 669 | 1951 | ||
| Alex Kampouris | 556 | 624 | 1939 | ||
| 300. | Joel Youngblood | 555 | 600 | 1983 |
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