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| Second Basemen Career Batting Average Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Batting Average | PA | Years | Single Season Leaderboard |
| 1. | Paul Molitor | .3161 | 7915 | 1978-1990 | |
| 2. | Tom Herr | .3103 | 6147 | 1981-1990 | |
| 3. | Cecil Travis | .3086 | 7099 | 1934-1948 | |
| 4. | Billy Herman | .3042 | 7161 | 1932-1945 | |
| 5. | Pee Wee Reese * | .3032 | 10850 | 1940-1956 | |
| 6. | Tony Lazzeri * | .2994 | 7117 | 1930-1941 | |
| 7. | George Grantham | .2987 | 3075 | 1930-1936 | |
| 8. | Rick Manning | .2968 | 6261 | 1975-1988 | |
| 9. | Mark Koenig | .2966 | 5408 | 1930-1941 | |
| 10. | Hughie Critz | .2962 | 4335 | 1930-1937 | |
| 11. | Mickey Rivers | .2949 | 4843 | 1973-1982 | |
| 12. | Stan Hack | .2948 | 9770 | 1933-1947 | |
| 13. | Ted Sizemore | .2943 | 5889 | 1970-1981 | |
| 14. | Gil McDougald * | .2934 | 8973 | 1951-1965 | |
| 15. | Grady Hatton | .2927 | 5328 | 1946-1953 | |
| 16. | Johnny Hodapp | .2925 | 5384 | 1930-1941 | |
| 17. | Lee Walls | .2915 | 8031 | 1955-1969 | |
| 18. | Joe Caffie | .2908 | 4441 | 1957-1969 | |
| 19. | Willie Horton | .2893 | 8507 | 1965-1980 | |
| 20. | Bill Cissell | .2891 | 3704 | 1930-1941 | |
| 21. | Bump Wills | .2889 | 7130 | 1977-1988 | |
| 22. | Doc Gautreau | .2882 | 4782 | 1930-1938 | |
| 23. | Jerry Standaert | .2871 | 3697 | 1930-1938 | |
| 24. | Don Blasingame | .2864 | 7457 | 1956-1970 | |
| 25. | Pete Runnels | .2858 | 7114 | 1952-1964 | |
| 26. | Ken Boswell | .2856 | 5015 | 1971-1981 | |
| 27. | Rance Mulliniks | .2848 | 7767 | 1978-1990 | |
| 28. | Billy Cox | .2840 | 7479 | 1941-1957 | |
| 29. | Rod Carew | .2837 | 9409 | 1967-1983 | |
| 30. | Rob Andrews | .2834 | 4285 | 1976-1987 | |
| 31. | Max Bishop | .2829 | 4901 | 1930-1938 | |
| 32. | Tito Fuentes | .2827 | 5415 | 1966-1981 | |
| 33. | Ron Theobald | .2824 | 3734 | 1971-1978 | |
| 34. | Bernie James | .2823 | 3697 | 1930-1941 | |
| 35. | Billy Johnson | .2819 | 5364 | 1943-1957 | |
| 36. | Paul Schaal | .2815 | 6529 | 1965-1979 | |
| 37. | Lou Stringer | .2813 | 6251 | 1941-1954 | |
| 38. | Kiko Garcia | .2812 | 5644 | 1979-1990 | |
| 39. | Lee Lacy | .2811 | 7483 | 1972-1986 | |
| 40. | Bobby Avila | .2804 | 4265 | 1949-1960 | |
| 41. | Lou Whitaker | .2800 | 7303 | 1978-1990 | |
| 42. | Terry Harmon | .2793 | 4749 | 1970-1979 | |
| 43. | Jorge Orta | .2787 | 7336 | 1976-1988 | |
| 44. | Marty Martinez | .2783 | 6264 | 1962-1978 | |
| 45. | Joe Morgan | .2778 | 11796 | 1963-1982 | |
| 46. | Roy Hartsfield | .2775 | 4471 | 1950-1958 | |
| 47. | Dion James | .2770 | 3016 | 1984-1990 | |
| 48. | Eddie Stanky | .2766 | 5930 | 1943-1953 | |
| 49. | Damaso Garcia | .2762 | 3357 | 1980-1990 | |
| 50. | Jack Perconte | .2758 | 5399 | 1980-1990 | |
| 51. | Billy Myers | .2736 | 4858 | 1935-1949 | |
| 52. | Lonny Frey | .2736 | 3718 | 1935-1946 | |
| 53. | Fresco Thompson | .2736 | 3284 | 1930-1937 | |
| 54. | Red Schoendienst | .2728 | 3142 | 1947-1959 | |
| 55. | Dutch Meyer | .2719 | 5288 | 1941-1952 | |
| 56. | Jim Bucher | .2718 | 5654 | 1936-1949 | |
| 57. | Rudy Meoli | .2713 | 3268 | 1977-1989 | |
| 58. | Bobby Reeves | .2709 | 4861 | 1930-1939 | |
| 59. | Charlie Gehringer | .2699 | 4091 | 1930-1939 | |
| 60. | Chuck Schilling | .2697 | 6580 | 1962-1974 | |
| 61. | Derrel Thomas | .2687 | 3085 | 1977-1983 | |
| 62. | Chico Carrasquel | .2684 | 6237 | 1951-1964 | |
| 63. | Tom Upton | .2682 | 5226 | 1953-1964 | |
| 64. | Jim Gilliam | .2676 | 6930 | 1953-1963 | |
| 65. | Bama Rowell | .2663 | 3696 | 1941-1953 | |
| 66. | Bobby Grich | .2655 | 7379 | 1973-1985 | |
| 67. | Bert Campaneris | .2647 | 4375 | 1965-1975 | |
| 68. | Felix Millan | .2639 | 5199 | 1968-1980 | |
| 69. | Jerry Terrell | .2635 | 4782 | 1973-1982 | |
| 70. | Lenn Sakata | .2633 | 3345 | 1983-1990 | |
| 71. | Johnny Lucadello | .2622 | 6957 | 1940-1954 | |
| 72. | Joel Youngblood | .2621 | 4993 | 1977-1986 | |
| 73. | Leo Cardenas | .2619 | 6972 | 1961-1977 | |
| 74. | Bernie Allen | .2615 | 4142 | 1962-1972 | |
| 75. | Jim Lefebvre | .2604 | 6564 | 1966-1978 | |
| 76. | Gary Geiger | .2601 | 7277 | 1960-1973 | |
| 77. | Alex Kampouris | .2594 | 8618 | 1934-1949 | |
| 78. | Stu Martin | .2583 | 3608 | 1937-1947 | |
| 79. | Mike De La Hoz | .2579 | 6019 | 1962-1976 | |
| 80. | Rodney Scott | .2546 | 6432 | 1977-1990 | |
| 81. | Frank Bolling | .2543 | 3545 | 1957-1968 | |
| 82. | Pedro Garcia | .2524 | 5561 | 1975-1986 | |
| 83. | Al Kozar | .2523 | 3047 | 1949-1955 | |
| 84. | Taylor Duncan | .2522 | 5305 | 1978-1989 | |
| 85. | George Strickland | .2519 | 4271 | 1954-1962 | |
| 86. | Davey Lopes | .2518 | 3628 | 1972-1978 | |
| 87. | Tommy Glaviano | .2514 | 6901 | 1951-1962 | |
| 88. | Hank Thompson | .2486 | 8521 | 1947-1962 | |
| 89. | Don Demeter | .2481 | 7229 | 1958-1971 | |
| 90. | Jim Davenport | .2481 | 3359 | 1958-1968 | |
| 91. | Solly Hemus | .2471 | 5849 | 1949-1960 | |
| 92. | Ryne Sandberg | .2455 | 5379 | 1981-1990 | |
| 93. | Greg Luzinski | .2436 | 10636 | 1971-1988 | |
| 94. | Rob Ellis | .2407 | 4143 | 1975-1986 | |
| 95. | Sherry Robertson | .2395 | 5770 | 1942-1955 | |
| 96. | Gene Stephens | .2383 | 6242 | 1955-1969 | |
| 97. | Charley Smith | .2331 | 3908 | 1961-1972 | |
| 98. | Juan Samuel | .2305 | 4225 | 1983-1990 | |
| 99. | Johnny Goryl | .2301 | 4973 | 1960-1970 | |
| 100. | Joe Gordon | .2294 | 3989 | 1938-1950 | |
| 101. | Don Buddin | .2254 | 4566 | 1958-1971 | |
| 102. | Randy Ready | .2208 | 3950 | 1983-1990 | |
| 103. | Tim Teufel | .2167 | 3207 | 1983-1990 | |
| 104. | Nelson Mathews | .2146 | 4788 | 1964-1974 | |
| 105. | Paul Runge | .1961 | 3021 | 1985-1990 |
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