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| First Basemen Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Aaron Pointer | 176 | 715 | 1969 | |
| 2. | Mark McGwire | 169 | 657 | 1990 | |
| 3. | Mark McGwire | 166 | 650 | 1989 | |
| Aaron Pointer | 166 | 654 | 1967 | ||
| 5. | Aaron Pointer | 160 | 657 | 1966 | |
| 6. | Steve Bilko | 159 | 644 | 1959 | |
| 7. | Ron Jackson | 155 | 609 | 1966 | |
| Steve Bilko | 155 | 652 | 1957 | ||
| 9. | Steve Bilko | 154 | 619 | 1955 | |
| Steve Bilko | 154 | 668 | 1954 | ||
| 11. | Mark McGwire | 152 | 674 | 1988 | |
| Steve Bilko | 152 | 669 | 1958 | ||
| 13. | Jason Thompson | 151 | 658 | 1986 | |
| Vic Wertz | 151 | 627 | 1960 | ||
| Eddie Yost | 151 | 675 | 1959 | ||
| 16. | Aaron Pointer | 150 | 601 | 1972 | |
| Ron Jackson | 150 | 618 | 1963 | ||
| 18. | Donn Clendenon | 149 | 589 | 1972 | |
| Steve Bilko | 149 | 666 | 1953 | ||
| 20. | Willie McCovey | 148 | 585 | 1969 | |
| 21. | Donn Clendenon | 147 | 613 | 1969 | |
| 22. | Ron Santo | 146 | 644 | 1976 | |
| Joe Gaines | 146 | 627 | 1969 | ||
| 24. | Aaron Pointer | 145 | 632 | 1975 | |
| Kent Hadley | 145 | 583 | 1962 | ||
| Joe Adcock | 145 | 626 | 1960 | ||
| 27. | Andres Galarraga | 144 | 637 | 1988 | |
| Cecil Fielder | 144 | 567 | 1988 | ||
| Kent Hadley | 144 | 607 | 1968 | ||
| 30. | Tony Solaita | 143 | 649 | 1972 | |
| 31. | Andres Galarraga | 142 | 666 | 1989 | |
| Kent Hadley | 142 | 608 | 1969 | ||
| Eddie Yost | 142 | 642 | 1960 | ||
| 34. | Gorman Thomas | 141 | 620 | 1983 | |
| Aaron Pointer | 141 | 595 | 1971 | ||
| 36. | Gorman Thomas | 140 | 618 | 1980 | |
| 37. | Sam Horn | 139 | 492 | 1989 | |
| Joe Adcock | 139 | 641 | 1959 | ||
| 39. | Tony Solaita | 138 | 686 | 1978 | |
| Willie McCovey | 138 | 584 | 1967 | ||
| 41. | Roy Howell | 137 | 560 | 1986 | |
| 42. | Steve Bilko | 136 | 518 | 1956 | |
| 43. | Edgar Martinez | 135 | 644 | 1990 | |
| Leon Durham | 135 | 609 | 1988 | ||
| Andres Galarraga | 135 | 610 | 1986 | ||
| Roger Freed | 135 | 571 | 1973 | ||
| 47. | Sam Horn | 134 | 560 | 1990 | |
| Tony Solaita | 134 | 652 | 1979 | ||
| Ron Santo | 134 | 656 | 1974 | ||
| Ed Bouchee | 134 | 592 | 1961 | ||
| 51. | Jason Thompson | 133 | 597 | 1987 | |
| Tony Solaita | 133 | 618 | 1977 | ||
| Willie McCovey | 133 | 523 | 1970 | ||
| Willie McCovey | 133 | 558 | 1968 | ||
| Ed Bouchee | 133 | 639 | 1965 | ||
| Ed Bouchee | 133 | 617 | 1964 | ||
| 57. | Andres Galarraga | 132 | 626 | 1990 | |
| Willie McCovey | 132 | 657 | 1965 | ||
| Eddie Yost | 132 | 701 | 1958 | ||
| 60. | Steve Kemp | 131 | 419 | 1989 | |
| Ed Bouchee | 131 | 594 | 1960 | ||
| Willie McCovey | 131 | 522 | 1960 | ||
| Eddie Yost | 131 | 687 | 1957 | ||
| Hank Greenberg * | 131 | 699 | 1944 | ||
| 65. | Jesse Barfield | 130 | 516 | 1987 | |
| Jason Thompson | 130 | 651 | 1985 | ||
| Tony Solaita | 130 | 631 | 1980 | ||
| Eddie Lukon | 130 | 603 | 1958 | ||
| Ed Morgan | 130 | 603 | 1939 | ||
| 70. | Leon Durham | 129 | 627 | 1986 | |
| Jason Thompson | 129 | 674 | 1984 | ||
| Gorman Thomas | 129 | 585 | 1982 | ||
| Joe Gaines | 129 | 626 | 1973 | ||
| Willie McCovey | 129 | 627 | 1966 | ||
| Ron Jackson | 129 | 610 | 1962 | ||
| 76. | Jesse Barfield | 128 | 578 | 1989 | |
| Tony Solaita | 128 | 587 | 1973 | ||
| Willie McCovey | 128 | 640 | 1961 | ||
| 79. | Willie Aikens | 127 | 584 | 1980 | |
| Steve Bilko | 127 | 575 | 1960 | ||
| 81. | Jason Thompson | 126 | 658 | 1983 | |
| Tony Solaita | 126 | 700 | 1981 | ||
| Donn Clendenon | 126 | 541 | 1970 | ||
| Steve Bilko | 126 | 640 | 1961 | ||
| Cliff Mapes | 126 | 511 | 1956 | ||
| Charlie Keller | 126 | 574 | 1952 | ||
| Merv Connors | 126 | 638 | 1939 | ||
| 88. | Curt Blefary | 125 | 658 | 1979 | |
| Byron Browne | 125 | 494 | 1972 | ||
| 90. | Eddie Lukon | 124 | 643 | 1957 | |
| Fred Sington | 124 | 618 | 1946 | ||
| 92. | Steve Garvey | 123 | 566 | 1980 | |
| 93. | Willie McCovey | 122 | 567 | 1971 | |
| Norm Cash | 122 | 602 | 1968 | ||
| Joe Adcock | 122 | 636 | 1963 | ||
| 96. | Leon Durham | 121 | 618 | 1987 | |
| Leon Durham | 121 | 587 | 1985 | ||
| Tony Solaita | 121 | 534 | 1975 | ||
| Willie McCovey | 121 | 640 | 1962 | ||
| Joe Adcock | 121 | 650 | 1961 | ||
| 101. | Leon Durham | 120 | 646 | 1983 | |
| Donn Clendenon | 120 | 614 | 1968 | ||
| Charlie Keller | 120 | 704 | 1950 | ||
| 104. | Randy Milligan | 119 | 627 | 1990 | |
| Randy Milligan | 119 | 573 | 1989 | ||
| Andres Galarraga | 119 | 556 | 1987 | ||
| Randy Jackson | 119 | 653 | 1960 | ||
| Hank Greenberg * | 119 | 665 | 1939 | ||
| Lou Gehrig | 119 | 634 | 1938 | ||
| 110. | Orestes Destrade | 118 | 490 | 1989 | |
| Aaron Pointer | 118 | 471 | 1968 | ||
| Bill Skowron | 118 | 493 | 1967 | ||
| 113. | Jesse Barfield | 117 | 522 | 1990 | |
| Chili Davis | 117 | 673 | 1989 | ||
| Steve Garvey | 117 | 551 | 1983 | ||
| Donn Clendenon | 117 | 497 | 1964 | ||
| Steve Bilko | 117 | 612 | 1962 | ||
| Harry Simpson | 117 | 520 | 1962 | ||
| Dale Long | 117 | 587 | 1960 | ||
| 120. | Steve Kemp | 116 | 705 | 1988 | |
| Steve Garvey | 116 | 587 | 1981 | ||
| Norm Cash | 116 | 633 | 1966 | ||
| Hank Greenberg * | 116 | 650 | 1945 | ||
| 124. | Willie Aikens | 115 | 575 | 1982 | |
| Roy Howell | 115 | 562 | 1980 | ||
| 126. | Leon Durham | 114 | 485 | 1989 | |
| Sam Horn | 114 | 573 | 1988 | ||
| Ken Phelps | 114 | 512 | 1984 | ||
| Kent Hadley | 114 | 517 | 1963 | ||
| Eddie Yost | 114 | 658 | 1956 | ||
| Eddie Yost | 114 | 660 | 1953 | ||
| 132. | Sixto Lezcano | 113 | 559 | 1979 | |
| 133. | Ron Santo | 112 | 642 | 1975 | |
| Jim Gentile | 112 | 489 | 1965 | ||
| Don Hurst | 112 | 512 | 1940 | ||
| 136. | Paul Sorrento | 111 | 490 | 1990 | |
| Billy Conigliaro | 111 | 631 | 1976 | ||
| Kent Hadley | 111 | 534 | 1966 | ||
| Don Lenhardt | 111 | 657 | 1953 | ||
| 140. | Jason Thompson | 110 | 479 | 1988 | |
| Steve Garvey | 110 | 606 | 1982 | ||
| Nate Colbert | 110 | 557 | 1981 | ||
| Roger Freed | 110 | 448 | 1972 | ||
| Willie Smith | 110 | 509 | 1971 | ||
| Sam Bowens | 110 | 420 | 1965 | ||
| Steve Bilko | 110 | 651 | 1963 | ||
| Randy Jackson | 110 | 661 | 1957 | ||
| 148. | Frank Thomas | 109 | 525 | 1990 | |
| Gorman Thomas | 109 | 622 | 1981 | ||
| Wayne Cage | 109 | 531 | 1979 | ||
| Randy Jackson | 109 | 592 | 1962 | ||
| Randy Jackson | 109 | 599 | 1961 | ||
| Donn Clendenon | 109 | 352 | 1961 | ||
| Charlie Keller | 109 | 629 | 1951 | ||
| 155. | Randy Milligan | 108 | 548 | 1988 | |
| Claudell Washington | 108 | 528 | 1986 | ||
| Carmen Castillo | 108 | 503 | 1984 | ||
| Byron Browne | 108 | 519 | 1971 | ||
| Joe Adcock | 108 | 648 | 1962 | ||
| Norm Cash | 108 | 641 | 1961 | ||
| Joe Adcock | 108 | 646 | 1956 | ||
| Fred Sington | 108 | 641 | 1945 | ||
| 163. | Ron Santo | 107 | 665 | 1973 | |
| Joe Gaines | 107 | 539 | 1968 | ||
| Norm Cash | 107 | 590 | 1959 | ||
| Norm Zauchin | 107 | 585 | 1956 | ||
| 167. | Leon Durham | 106 | 500 | 1990 | |
| Mike Brown | 106 | 614 | 1989 | ||
| Ken Phelps | 106 | 611 | 1989 | ||
| Chili Davis | 106 | 593 | 1982 | ||
| Mike Fiore | 106 | 487 | 1971 | ||
| Joe Gaines | 106 | 610 | 1970 | ||
| Kent Hadley | 106 | 548 | 1964 | ||
| Joe Adcock | 106 | 642 | 1958 | ||
| Charlie Keller | 106 | 671 | 1949 | ||
| Hank Greenberg * | 106 | 686 | 1943 | ||
| 177. | David Green | 105 | 617 | 1988 | |
| Tony Solaita | 105 | 547 | 1982 | ||
| Jason Thompson | 105 | 641 | 1981 | ||
| Mike Epstein | 105 | 595 | 1973 | ||
| Wes Parker | 105 | 641 | 1967 | ||
| Joe Adcock | 105 | 487 | 1964 | ||
| Jim Gentile | 105 | 437 | 1958 | ||
| Hank Greenberg * | 105 | 703 | 1941 | ||
| 185. | Claudell Washington | 104 | 634 | 1981 | |
| Andre Thornton | 104 | 659 | 1980 | ||
| Curt Blefary | 104 | 626 | 1978 | ||
| Norm Cash | 104 | 625 | 1965 | ||
| Wayne Belardi | 104 | 634 | 1960 | ||
| 190. | Luis Medina | 103 | 476 | 1990 | |
| Hank Greenberg * | 103 | 687 | 1942 | ||
| Gene Hasson | 103 | 564 | 1939 | ||
| 193. | Dave Parker | 102 | 520 | 1986 | |
| Tom Paciorek | 102 | 523 | 1981 | ||
| Gorman Thomas | 102 | 542 | 1978 | ||
| Bill Robinson | 102 | 574 | 1976 | ||
| Donn Clendenon | 102 | 648 | 1967 | ||
| Vic Wertz | 102 | 615 | 1959 | ||
| Charlie Keller | 102 | 616 | 1944 | ||
| Gene Hasson | 102 | 652 | 1943 | ||
| Charlie Keller | 102 | 669 | 1942 | ||
| 202. | Chili Davis | 101 | 672 | 1990 | |
| Steve Balboni | 101 | 445 | 1982 | ||
| Joe Gaines | 101 | 510 | 1972 | ||
| Willie McCovey | 101 | 653 | 1964 | ||
| Norm Cash | 101 | 646 | 1962 | ||
| Bobby Brown | 101 | 509 | 1962 | ||
| Eddie Yost | 101 | 671 | 1950 | ||
| Charlie Keller | 101 | 684 | 1943 | ||
| Don Hurst | 101 | 481 | 1941 | ||
| 211. | Willie Aikens | 100 | 501 | 1981 | |
| Richie Scheinblum | 100 | 527 | 1979 | ||
| Joe Hague | 100 | 633 | 1971 | ||
| Willie Smith | 100 | 522 | 1969 | ||
| Roman Mejias | 100 | 620 | 1962 | ||
| Don Lenhardt | 100 | 497 | 1957 | ||
| Charlie Keller | 100 | 670 | 1941 | ||
| 218. | Willie McCovey | 99 | 471 | 1972 | |
| Joe Gaines | 99 | 646 | 1971 | ||
| Aaron Pointer | 99 | 422 | 1970 | ||
| Norm Cash | 99 | 632 | 1967 | ||
| Jim Gentile | 99 | 584 | 1962 | ||
| Darrell Johnson | 99 | 515 | 1960 | ||
| Randy Jackson | 99 | 646 | 1959 | ||
| Connie Ryan | 99 | 632 | 1951 | ||
| Charlie Keller | 99 | 642 | 1948 | ||
| Hank Greenberg * | 99 | 687 | 1940 | ||
| 228. | Willie Upshaw | 98 | 658 | 1990 | |
| Mike Brown | 98 | 605 | 1988 | ||
| Leon Durham | 98 | 610 | 1981 | ||
| Donn Clendenon | 98 | 605 | 1966 | ||
| Ron Santo | 98 | 637 | 1963 | ||
| Roman Mejias | 98 | 503 | 1960 | ||
| Eddie Yost | 98 | 670 | 1955 | ||
| Gene Hasson | 98 | 632 | 1947 | ||
| 236. | Willie McCovey | 97 | 639 | 1963 | |
| Joe Adcock | 97 | 660 | 1957 | ||
| Dale Long | 97 | 570 | 1953 | ||
| Eddie Yost | 97 | 673 | 1951 | ||
| Merv Connors | 97 | 662 | 1946 | ||
| 241. | Glenn Davis | 96 | 618 | 1989 | |
| Jesse Barfield | 96 | 431 | 1988 | ||
| David Green | 96 | 533 | 1987 | ||
| Mike Pagliarulo | 96 | 559 | 1986 | ||
| Glenn Davis | 96 | 578 | 1984 | ||
| Gary Gray | 96 | 622 | 1983 | ||
| Dave Parker | 96 | 652 | 1982 | ||
| Ron Santo | 96 | 671 | 1972 | ||
| Mike Fiore | 96 | 484 | 1972 | ||
| Nate Colbert | 96 | 371 | 1972 | ||
| Ron Santo | 96 | 646 | 1962 | ||
| Wayne Belardi | 96 | 637 | 1961 | ||
| Eddie Yost | 96 | 338 | 1961 | ||
| Harry Simpson | 96 | 632 | 1959 | ||
| 255. | Jeff McKnight | 95 | 560 | 1989 | |
| Gary Gray | 95 | 641 | 1984 | ||
| Claudell Washington | 95 | 575 | 1982 | ||
| Leon Durham | 95 | 560 | 1982 | ||
| Tony Solaita | 95 | 500 | 1976 | ||
| Wayne Belardi | 95 | 549 | 1959 | ||
| Ray Sanders | 95 | 602 | 1954 | ||
| Merv Connors | 95 | 629 | 1948 | ||
| Charlie Keller | 95 | 632 | 1946 | ||
| Ed Morgan | 95 | 566 | 1938 | ||
| Lou Gehrig | 95 | 657 | 1937 | ||
| 266. | Phil Bradley | 94 | 621 | 1989 | |
| Edgar Martinez | 94 | 660 | 1988 | ||
| Chili Davis | 94 | 661 | 1984 | ||
| Dave Parker | 94 | 632 | 1983 | ||
| Gorman Thomas | 94 | 435 | 1979 | ||
| Mike Epstein | 94 | 462 | 1978 | ||
| Mike Epstein | 94 | 500 | 1975 | ||
| Rick Joseph | 94 | 565 | 1974 | ||
| Tony Solaita | 94 | 504 | 1974 | ||
| Donn Clendenon | 94 | 406 | 1971 | ||
| Ray Barker | 94 | 386 | 1969 | ||
| Ron Santo | 94 | 659 | 1968 | ||
| Wes Parker | 94 | 623 | 1966 | ||
| Dale Long | 94 | 566 | 1959 | ||
| Vic Wertz | 94 | 645 | 1958 | ||
| Bill Skowron | 94 | 586 | 1958 | ||
| Frank Kellert | 94 | 529 | 1957 | ||
| Randy Jackson | 94 | 651 | 1956 | ||
| Gene Hasson | 94 | 630 | 1940 | ||
| 285. | Cecil Cooper | 93 | 394 | 1990 | |
| Clint Hurdle | 93 | 687 | 1988 | ||
| Chili Davis | 93 | 683 | 1988 | ||
| Tom Paciorek | 93 | 630 | 1977 | ||
| Billy Conigliaro | 93 | 578 | 1975 | ||
| Billy Klaus | 93 | 476 | 1960 | ||
| Eddie Lukon | 93 | 630 | 1956 | ||
| Joe Adcock | 93 | 658 | 1955 | ||
| Joe Adcock | 93 | 673 | 1954 | ||
| Luke Easter | 93 | 611 | 1948 | ||
| 295. | Mike Brown | 92 | 597 | 1985 | |
| Phil Bradley | 92 | 560 | 1985 | ||
| Mike Ivie | 92 | 540 | 1984 | ||
| Pat Tabler | 92 | 582 | 1983 | ||
| Roy Howell | 92 | 619 | 1981 | ||
| Andre Thornton | 92 | 583 | 1981 |
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